2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)
- Product Name
- 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)
- CAS No.
- 59989-18-3
- Chemical Name
- 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)
- Synonyms
- GW-776;GW776C85;ADH-300004;NSC 687296;5-ethynyluracil;5-Ethynyluracil>Eniluracil (5-Ethynyluracil;5-Ethynyl-1H-pyrimidine-2,4-dione;5-Ethynyl-2,4(1H,3H)-pyriMidinedione;5-EthynylpyriMidine-2,4(1H,3H)-dione
- CBNumber
- CB61081129
- Molecular Formula
- C6H4N2O2
- Formula Weight
- 136.11
- MOL File
- 59989-18-3.mol
2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Property
- Melting point:
- 320° (dec)
- Density
- 1.527
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Soluble in DMSO
- form
- solid
- pka
- 7.44±0.10(Predicted)
- color
- Yellow
- λmax
- 284nm(MeOH)(lit.)
- Merck
- 14,3584
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety
- HS Code
- 2933.59.9500
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E1096
- Product name
- 5-Ethynyluracil
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 200mg
- Price
- $201
- Updated
- 2024/03/01
- Product number
- E1096
- Product name
- 5-Ethynyluracil
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $696
- Updated
- 2024/03/01
- Product number
- E558650
- Product name
- Eniluracil
- Packaging
- 10mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- E558650
- Product name
- Eniluracil
- Packaging
- 1g
- Price
- $495
- Updated
- 2021/12/16
- Product number
- API0005199
- Product name
- ENILURACIL
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $779.63
- Updated
- 2021/12/16
2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Chemical Properties,Usage,Production
Description
Eniluracil (59989-18-3) is an irreversible dihydropyrimidine dehydrogenase (DPD) inhibitor.1-3? DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU).? Eniluracil has been used along with 5-FU to prolong circulating concentrations of the drug.
Uses
Potent inactivator of Dihydropyrimidine dehydrogenase (DPD).
Definition
ChEBI: Eniluracil is a pyrimidone.
References
1) Porter?et al. (1992),?Mechanism-based Inactivation of Dihydropyrimidine Dehydrogenase by 5-Ethynyluracil; J. Biol. Chem.,?267?5236 2) Baccalnari?et al. (1993),?5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil; Proc. Natl. Acad. Sci. USA,?90?11064 3) Schilsky and Kindler (2000)?Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase; Expert Opin. Investig. Drugs,?9?1635
2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI) Suppliers
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