2-Chloro-4-nitroimidazole
- Product Name
- 2-Chloro-4-nitroimidazole
- CAS No.
- 57531-37-0
- Chemical Name
- 2-Chloro-4-nitroimidazole
- Synonyms
- 2-Chloro-4-nitro-1H-imidazole;TIMTEC-BB SBB000100;2-Chloro-4-nitro-1H-;2-Chloro-5-nitroimidazole;2-CHLORO-4-NITROIMIDAZOLE;2-Chloro-4(5)-nitroiMidazole;2-CHLORO-5-NITRO-1H-IMIDAZOLE;5-chloro-2-nitro-1H-iMidazole;2-chloro-4-nitro-3H-imidazole;2-Chloro-5-nitroimidazole,95%
- CBNumber
- CB6108658
- Molecular Formula
- C3H2ClN3O2
- Formula Weight
- 147.52
- MOL File
- 57531-37-0.mol
2-Chloro-4-nitroimidazole Property
- Melting point:
- 216-217 °C
- Boiling point:
- 386.8±34.0 °C(Predicted)
- Density
- 1.740±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated)
- pka
- 5.65±0.10(Predicted)
- form
- Solid
- color
- Off-White to Pale Beige
- InChI
- InChI=1S/C3H2ClN3O2/c4-3-5-1-2(6-3)7(8)9/h1H,(H,5,6)
- InChIKey
- BOJZBRDIZUHTCE-UHFFFAOYSA-N
- SMILES
- C1(Cl)NC([N+]([O-])=O)=CN=1
- CAS DataBase Reference
- 57531-37-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C373935
- Product name
- 2-Chloro-4-nitroimidazole
- Packaging
- 100g
- Price
- $2360
- Updated
- 2021/12/16
- Product number
- OR2577
- Product name
- 2-Chloro-4-nitro-1H-imidazole
- Packaging
- 1g
- Price
- $22
- Updated
- 2021/12/16
- Product number
- 4H54-5-Z3
- Product name
- 2-Chloro-4-nitro-1H-imidazole
- Packaging
- 1g
- Price
- $28
- Updated
- 2021/12/16
- Product number
- FC20104
- Product name
- 2-Chloro-4-nitroimidazole
- Packaging
- 5G
- Price
- $50
- Updated
- 2021/12/16
- Product number
- OR2577
- Product name
- 2-Chloro-4-nitro-1H-imidazole
- Packaging
- 5g
- Price
- $58
- Updated
- 2021/12/16
2-Chloro-4-nitroimidazole Chemical Properties,Usage,Production
Chemical Properties
Light yellow solid
Uses
4-Nitroimidazole derivative with poetenial use as radiosensitizers of hypoxic cells. It is used in the preparation of antitubercular nitroimidazoles.
Uses
4-Nitroimidazole derivative with poetenial use as radiosensitizers of hypoxic cells. 2-Chloro-4-nitroimidazole is used in the preparation of antitubercular nitroimidazoles.
Synthesis
683276-67-7
57531-37-0
Example 9 Preparation of 2-chloro-4-nitroimidazole: 2-chloro-5-iodo-4-nitroimidazole (273 mg, 1.0 mmol) was dissolved in anhydrous ethanol (5 mL), followed by sequential addition of triethylamine (420 μL, 3.0 mmol) and 10% palladium-carbon catalyst (27 mg) to the solution. The reaction mixture was hydrogenated by stirring for 3 hours at room temperature and under an atmosphere of hydrogen at atmospheric pressure. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford the colorless solid product 2-chloro-4-nitroimidazole (124 mg, 84.1% yield). The product was characterized by 1H-NMR (DMSO-d6): δ 8.44 (1H, s), 14.19 (1H, bs). Example 11 Preparation of 2-chloro-4-nitroimidazole: 2-chloro-5-iodo-4-nitroimidazole (545 mg, 2.0 mmol) was dissolved in anhydrous ethanol (10 mL), followed by sequential addition of triethylamine (840 μL, 6.0 mmol) and 10% palladium-carbon catalyst (54 mg) to the solution. The reaction mixture was hydrogenated under hydrogen pressure of 4 kg/cm2 in a pearl reduction apparatus. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to give the colorless solid product 2-chloro-4-nitroimidazole (246 mg, 83.4% yield). The product was characterized by 1H-NMR (DMSO-d6): δ 8.44 (1H, s), 14.19 (1H, bs).
References
[1] Patent: WO2005/77913, 2005, A1. Location in patent: Page/Page column 76-77
[2] Patent: EP1553088, 2005, A1. Location in patent: Page/Page column 58-59
[3] Patent: EP1553088, 2005, A1. Location in patent: Page/Page column 58
[4] Patent: EP1553088, 2005, A1. Location in patent: Page/Page column 59
2-Chloro-4-nitroimidazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-4-nitroimidazole manufacturers
- Product
- 2-Chloro-4-nitroimidazole 57531-37-0
- Price
- US $30.00-28.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.0% up
- Supply Ability
- 50 tons per month
- Release date
- 2022-09-26
- Product
- 2-Chloro-4-nitroimidazole 57531-37-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 2-Chloro-4-nitroimidazole 57531-37-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09