ChemicalBook > CAS DataBase List > 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide

Product Name
2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
CAS No.
302964-24-5
Chemical Name
2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Synonyms
EOS-61515;2-Amino-N-(2-chL;Dasatinib Int N-2;The dimer impurity;Dasatinib IMpurity 2;Dasatinib Impurity L;Dasatinib Impurity 27;dasatinib interMediate;Dasatinib EP Impurity-A;2-AMino-N-(2-chloro-6-Meth
CBNumber
CB61090897
Molecular Formula
C11H10ClN3OS
Formula Weight
267.73
MOL File
302964-24-5.mol
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2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide Property

Melting point:
208.0 to 212.0 °C
Boiling point:
362.0±37.0 °C(Predicted)
Density 
1.474±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMSO (Slightly), Methanol (Sparingly)
form 
powder to crystal
pka
11.09±0.70(Predicted)
color 
White to Light yellow
InChI
InChI=1S/C11H10ClN3OS/c1-6-3-2-4-7(12)9(6)15-10(16)8-5-14-11(13)17-8/h2-5H,1H3,(H2,13,14)(H,15,16)
InChIKey
VVOXTERFTAJMAA-UHFFFAOYSA-N
SMILES
S1C(C(NC2=C(C)C=CC=C2Cl)=O)=CN=C1N
CAS DataBase Reference
302964-24-5(CAS DataBase Reference)
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Safety

HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
A2773
Product name
2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$41
Updated
2024/03/01
TCI Chemical
Product number
A2773
Product name
2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$62
Updated
2024/03/01
TRC
Product number
A603910
Product name
2-Amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide
Packaging
10g
Price
$1455
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0029530
Product name
2-AMINO-N-(2-CHLORO-6-METHYLPHENYL)THIAZOLE-5-CARBOXAMIDE
Purity
95.00%
Packaging
1G
Price
$846.5
Updated
2021/12/16
SynQuest Laboratories
Product number
8H70-5-X5
Product name
2-Amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide
Purity
98%
Packaging
100g
Price
$1149
Updated
2021/12/16
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2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide Chemical Properties,Usage,Production

Uses

2-Amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide, is a precursor in the synthesis of Dasatinib (D193600), a protein tyrosine kinase inhibitor, and also for 2-Amino-thiazole-5-carboxylic Acid Phenylamide Derivatives, used as potent and selective anti-tumor drugs.

Synthesis

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide is synthesised using Tert-butyl (5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-YL)carbamate as a raw material by chemical reaction. The specific synthesis steps are as follows:
To the stirred solution of trifluoroacetic acid (TFA) (250.0 mL) added tert-butyl (5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)carbamate 23 (25.0 g, 0.07 mol) and stirred for 2h at 25-30°C. Reaction completion was confirmed by TLC, distilled the TFA and the residue was diluted with ethyl acetate (EtOAc),(250.0 mL). Ethyl acetate layer was washed with saturated NaHCO3 solution (2 X 25.0 mL), water, followed bysaturated NaCl solution (125.0 mL). Ethyl acetate layer was dried over Na2SO4 and concentrated. The residual mass on treatment with methyl tert-butyl ether (250.0) gave 9 (16.2 g, 89percent) [11].IR (KBr, cm-1): 3382.4, 3284.85 (N-H), 1627.02 (C=O), 1644; 1H NMR spectrum (400 MHz, DMSO-d6), δ, ppm(J, Hz): 9.63 (s, 1H, thiazole-H), 7.86 (s, 1H), 7.60 (s, 2H, -NH2), 7.38 (dd, 1H, J =7.5, 4.02, Ar-H), 7.20-7.22 (m,2H, J =7.5, Ar-H), 2.20 (s, 3H, Ar-CH3); 13C NMR spectrum (100 MHz, DMSO-d6), δ, ppm: 172.2, 159.6, 143.2,138.9, 133.7, 132.5, 129.0, 128.0, 127.0, 120.7 and 18.3; MS (ESI) m/z 268.0 [M + H] + [11].

2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide manufacturers

Henan Fengda Chemical Co., Ltd
Product
2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide 302964-24-5
Price
US $6.00-0.20/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-28
Nanjing Fred Technology Co., Ltd
Product
2-amino-N-(2-chloro-6-methyl-phenyl)thiazole-5-carboxamide 302964-24-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-20
Hebei Guanlang Biotechnology Co,.LTD
Product
2-Amino-N- (2-chloro-6-methylphenyl) Thiazole-5-Carboxamide 302964-24-5
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2023-06-19

302964-24-5, 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamideRelated Search:

Dacomitinib (PF299804) Methyl 2-aminothiazole-5-carboxylate ETHYL 2-(TERT-BUTOXYCARBONYLAMINO)THIAZOLE-5-CARBOXYLATE 2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID 2-Chloro-6-methylaniline (E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide Dasatinib monohydrate (E)-3-Ethoxyacryloyl chloride N,N-Dimethylformamide N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Dasatinib ALTRENOGEST Epichlorohydrin N-Methylformamide Glycine N-Deshydroxyethyl Dasatinib Dasatinib Impurity 33 2-[[6-[4-(2-Hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxylic acid

  • 2-Amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide 98%
  • Dasatinib IMpurity 2
  • 2-AMino-N-(2-chloro-6-Methylphenyl)thiazole-5-carboxiMide)
  • 2-Amino-5-[(2-chloro-6-methylphenyl)carbamoyl]-1,3-thiazole, 2-Amino-5-[(6-chloro-o-tolyl)carbamoyl]-1,3-thiazole
  • 5-ThiazolecarboxaMide,2-aMino-N-(2-chloro-6-Methylphenyl)
  • Dasatinib Int N-2
  • 2-AMino-N-(2-chloro-6-Meth
  • 2-AMino-N-(2-chloro-6-Methylphenyl)-5-thiazolecarboxaMide
  • 2-Amino-<i>N</i>-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
  • 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide(Intermediate of Dasatinib)
  • 2-AMINO-N-(2-CHLORO-6-METHYLPHENYL)THIAZOLE-5-CARBOXAMIDE
  • EOS-61515
  • The dimer impurity
  • Dasatinib Impurity 27
  • 2-AMino-N-(2-chloro-6-Methylphenyl)thiazole-5-carb
  • 2-aMino-N-(2-chloro-6-Methylphenyl)-1,3-thiazole-5-carboxaMide
  • dasatinib interMediate
  • 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide &gt
  • 2-Amino-N-(2-chL
  • Dasatinib Aminothiazole Impurity
  • 2- Amino-N - (2-chloro-6-methylphenyl) thiazole-5-carboxylamide
  • Dasatinib Impurity L
  • 2-Amino-N - (2-chloro-6-methylphenyl) thiazole-5-formamide
  • 2-Amino-N-(2-chloro-6-methylphenyl)thiazol-5-carboxamide
  • 2-Amino-N - (2-chloro-6-methylphenyl) -5-thiazolamide
  • Dasatinib EP Impurity-A
  • 302964-24-5
  • 392064-08-5
  • Dasatinib
  • API intermediates