(E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide

Product Name: (E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide
CAS No.: 863127-76-8
Chemical Name: (E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide
Synonyms: SKL777;(Z)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide;(E)-N-(2-CHLORO-6-METHYLPHENYL)-3-ETHOXYACRYLAMIDE;(E) - N - (2-chloro-6-methylphenyl) -5-thiazolamide;(2E)-N-(2-Chloro-6-methylphenyl)-3-ethoxy-acrylamide;(E)-N-(2-chloro-6-methyl-phenyl)-3-ethoxyl acrylamide;(E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyprop-2-enamide;(2E)-N-(2-Chloro-6-methylphenyl)-3-ethoxy-2-propenamide;(2E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyprop-2-enamide;2-PropenaMide,N-(2-chloro-6-Methylphenyl)-3-ethoxy-, (2E)-
CBNumber: CB91478218
Molecular Formula: C12H14ClNO2
Formula Weight: 239.7
MOL File: 863127-76-8.mol

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(E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide Property

Boiling point:: 386.5±42.0 °C(Predicted)
Density: 1.197
storage temp.: Sealed in dry,Room Temperature
pka: 11.57±0.70(Predicted)
InChI: InChI=1S/C12H14ClNO2/c1-3-16-8-7-11(15)14-12-9(2)5-4-6-10(12)13/h4-8H,3H2,1-2H3,(H,14,15)/b8-7+
InChIKey: DBYFNZJHXGNAGW-BQYQJAHWSA-N
SMILES: C(NC1=C(C)C=CC=C1Cl)(=O)/C=C/OCC

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Safety

HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FC149928
Product name: (E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide
Packaging: 50mg
Price: $56
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC149928
Product name: (E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide
Packaging: 100mg
Price: $97
Updated: 2021/12/16

AK Scientific

Product number: 3496AC
Product name: (E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide
Packaging: 10g
Price: $151
Updated: 2021/12/16

Apolloscientific

Product number: OR321476
Product name: (E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide
Purity: 97%
Packaging: 10g
Price: $174
Updated: 2021/12/16

Apolloscientific

Product number: OR321476
Product name: (E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide
Purity: 97%
Packaging: 25g
Price: $319
Updated: 2021/12/16

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(E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide Chemical Properties,Usage,Production

Uses

(2E)-N-(2-Chloro-6-methylphenyl)-3-ethoxy-2-propenamide is a reagent used for the preparation of potent and selective anti-tumor drug Dasatinib.

Synthesis

6191-99-7

87-63-8

863127-76-8

3-Ethoxyacryloyl chloride (84.7 g, 0.63 mol) was slowly added dropwise to a tetrahydrofuran (THF, 600 mL) solution of 2-chloro-6-methylaniline (59.5 g, 0.42 mol) and pyridine (68 ml, 0.63 mol) cooled to 0-5°C with stirring, maintaining the reaction temperature at 0-5°C. After completion of the drop, the reaction mixture was gradually warmed to 20°C and stirring was continued for 2 hours. Subsequently, the reaction solution was cooled to 0-10°C and acidified by slowly adding 1N hydrochloric acid (115 mL). The reaction mixture was diluted with water (310 mL) and concentrated under reduced pressure to a thick slurry. The thick slurry was diluted with toluene (275 mL) and stirred at 20-22°C for 15 minutes, then continued stirring at 0°C for 1 hour. The precipitated solid was collected by vacuum filtration, washed with water (2 x 75 mL) and dried to give (E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide 74.1 g in 73.6% yield. The product was characterized by 1H NMR (400 MHz, DMSO-d6) and 13C NMR (100 MHz, CDCl3) with the following data: 1H NMR δ 1.26 (t, 3H, J=7Hz), 2.15 (s, 3H), 3.94 (q, 2H, J=7Hz), 5.58 (d, 1H, J=12.4Hz), 7.10- 7.27 (m, 2H), 7.27-7.37 (d, 1H, J=7.5Hz), 7.45 (d, 1H, J=12.4Hz), 9.28 (s, 1H); 13C NMR δ 14.57, 18.96, 67.17, 97.99, 126.80, 127.44, 129.07, 131.32. 132.89, 138.25, 161.09, 165.36.

References

[1] Archiv der Pharmazie, 2011, vol. 344, # 7, p. 451 - 458
[2] Patent: WO2005/77945, 2005, A2. Location in patent: Page/Page column 50-51
[3] Arkivoc, 2010, vol. 2010, # 6, p. 32 - 38
[4] Patent: WO2017/2131, 2017, A1. Location in patent: Page/Page column 17; 18

(E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide Preparation Products And Raw materials

Raw materials

Preparation Products

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(E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide Suppliers

China 142 India 7 United Kingdom 1 United States 8 Global 158

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View Lastest Price from (E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide manufacturers

Nanjing Fred Technology Co., Ltd

Product: (E)-N-(2-chloro-6-methyl-phen-yl)-3-ethoxyacrylamide 863127-76-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-20

Guangzhou PI PI BIOTECH INC

Product: Dasatinib Impurity 14 863127-76-8
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 90%+
Supply Ability: 10g
Release date: 2021-09-20

LY Global chemicals co.,ltd .

Product: (E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide 863127-76-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98.0%min
Supply Ability: 100kg
Release date: 2023-03-11

863127-76-8, (E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamideRelated Search:

ETHYL 2-(TERT-BUTOXYCARBONYLAMINO)THIAZOLE-5-CARBOXYLATE 2-N-BOC-AMINO-THIAZOLE-5-CARBOXYLIC ACID 2-Chloro-6-methylaniline 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Dasatinib monohydrate Dasatinib (E)-3-Ethoxyacryloyl chloride Acrylamide Epichlorohydrin N,N'-Methylenebisacrylamide N-Methylolacrylamide Methacrylamide Difluorochloromethane Chloroacetic acid Ethoxy (E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide

(E)-N-(2-CHLORO-6-METHYLPHENYL)-3-ETHOXYACRYLAMIDE

(2E)-N-(2-Chloro-6-methylphenyl)-3-ethoxy-2-propenamide

2-PropenaMide,N-(2-chloro-6-Methylphenyl)-3-ethoxy-, (2E)-

(E)-N-(2-chloro-6-methyl-phenyl)-3-ethoxyl acrylamide

(Z)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide

SKL777

(E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyacrylamide 863127-76-8

(2E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyprop-2-enamide

(2E)-N-(2-Chloro-6-methylphenyl)-3-ethoxy-acrylamide

(E)-N-(2-Chloro-6-methylphenyl)-3-ethoxyprop-2-enamide

(E) - N - (2-chloro-6-methylphenyl) -5-thiazolamide

863127-76-8