2-Bromo-5-fluoro-3-nitropyridine
- Product Name
- 2-Bromo-5-fluoro-3-nitropyridine
- CAS No.
- 652160-72-0
- Chemical Name
- 2-Bromo-5-fluoro-3-nitropyridine
- Synonyms
- LogP;2-BROMO-5-FLUORO-3-NITROPYRDINE;2-BROMO-5-FLUORO-3-NITROPYRIDINE;Pyridine, 2-bromo-5-fluoro-3-nitro-;2-BROMO-5-FLUORO-3-NITROPYRIDINE ISO 9001：2015 REACH
- CBNumber
- CB61092705
- Molecular Formula
- C5H2BrFN2O2
- Formula Weight
- 220.98
- MOL File
- 652160-72-0.mol
2-Bromo-5-fluoro-3-nitropyridine Property
- Boiling point:
- 227℃
- Density
- 1.923
- Flash point:
- 91℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Solid
- pka
- -5.67±0.20(Predicted)
- color
- Pale orange
- Water Solubility
- Slightly soluble in water.
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B692728
- Product name
- 2-Bromo-5-fluoro-3-nitropyridine
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B692728
- Product name
- 2-Bromo-5-fluoro-3-nitropyridine
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- PC400737
- Product name
- 2-Bromo-5-fluoro-3-nitropyridine
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- CS-W005456
- Product name
- 2-Bromo-5-fluoro-3-nitropyridine
- Purity
- ≥97.0%
- Packaging
- 5g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 074358
- Product name
- 2-Bromo-5-fluoro-3-nitropyridine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $29
- Updated
- 2021/12/16
2-Bromo-5-fluoro-3-nitropyridine Chemical Properties,Usage,Production
Uses
2-Bromo-5-fluoro-3-nitropyridine is a halogenated nitropyridine, which is often used in organic synthesis. 5-Fluoro-2-hydroxy-3-nitropyridine can be used as a raw material to synthesize 2-Bromo-5-fluoro-3-nitropyridine.
Synthesis
136888-20-5
652160-72-0
General procedure for the synthesis of 2-bromo-5-fluoro-3-nitropyridine from 2-hydroxy-3-nitro-5-fluoropyridine: 117 g of 2-hydroxy-3-nitro-5-fluoropyridine was divided into 4 batches (30 g x 3 and 27 g x 1) and treated with phosphorus tribromide (3 equiv; 163 g x 3 and 155 g x 1) and catalytic amount of N,N-dimethylformamide (15 mL), respectively. DMF was carefully added at room temperature with attention to gas release.After 5 min, the reaction mixture was heated to 110 °C and maintained for 3 h. The reaction mixture was then purified by LC/MS. Complete consumption of the feedstock was confirmed by LC/MS monitoring. After cooling the reaction mixture to room temperature, the reaction flask was placed in an ice bath. Ice was added to the flask slowly and carefully in batches, noting the escape of gas due to HBr generation. The resulting liquid and black solid were poured into the beaker containing ice. Ethyl acetate was added and the mixture was subsequently extracted several times with ethyl acetate. The organic layer was washed sequentially with saturated sodium bicarbonate solution, water and brine, dried over anhydrous sodium sulfate and filtered. The product was dried overnight in a vacuum pump to give 123 g of 2-bromo-5-fluoro-3-nitropyridine as a brown solid in 77% yield. Note: The reaction was completed in 1 h. 1H NMR (δ, CDCl3): 8.52 (m, 1H), 7.93 (m, 1H).
References
[1] Patent: US2004/110785, 2004, A1. Location in patent: Page 212
[2] Patent: US2006/142298, 2006, A1. Location in patent: Page/Page column 11; 14
[3] Patent: US2005/209246, 2005, A1. Location in patent: Page/Page column 31; 32
[4] Patent: US2004/6090, 2004, A1. Location in patent: Page/Page column 37
[5] Patent: WO2004/11425, 2004, A2. Location in patent: Page 79
2-Bromo-5-fluoro-3-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromo-5-fluoro-3-nitropyridine manufacturers
- Product
- 2-BROMO-5-FLUORO-3-NITROPYRIDINE 652160-72-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-14
- Product
- 2-BROMO-5-FLUORO-3-NITROPYRIDINE 652160-72-0
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-04