Capsaicin

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Description History Uses Application in Particular Diseases

Product Name: Capsaicin
CAS No.: 404-86-4
Chemical Name: Capsaicin
Synonyms: CAPSAICINE;Qutenza;Halt;TRANS-CAPSAICIN;CAPSAICINEXTRACT;Capsaicin(Vanilloid);hongdenafil,Acetildenafil;(E)-8-METHYL-NON-6-ENOIC ACID 4-HYDROXY-3-METHOXY-BENZYLAMIDE;ZK-A;Zacin
CBNumber: CB6112967
Molecular Formula: C18H27NO3
Formula Weight: 305.41
MOL File: 404-86-4.mol

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Capsaicin Property

Melting point:: 62-65 °C(lit.)
Boiling point:: 210-220 C
Density: 1.1037 (rough estimate)
refractive index: 1.5100 (estimate)
FEMA: 3404 | CAPSAICIN
Flash point:: 113 °C
storage temp.: 2-8°C
solubility: H₂O: insoluble
form: Off-white solid
pka: 9.76±0.20(Predicted)
color: Off-white
Odor: mild warm herbal
Odor Type: herbal
Water Solubility: insoluble
Merck: 14,1768
BRN: 2816484
Stability:: Stable. Incompatible with strong oxidizing agents.
InChIKey: YKPUWZUDDOIDPM-SOFGYWHQSA-N
LogP: 4.00
CAS DataBase Reference: 404-86-4(CAS DataBase Reference)
EPA Substance Registry System: Capsaicin (404-86-4)

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Safety

Hazard Codes: T,T+
Risk Statements: 25-37/38-41-42/43-36/37/38
Safety Statements: 22-26-28-36/39-45-36/37/39
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: RA8530000
F: 10-21
HazardClass: 6.1(a)
PackingGroup: II
HS Code: 29399990
Hazardous Substances Data: 404-86-4(Hazardous Substances Data)
Toxicity: LD50 oral in mouse: 47200ug/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 21750
Product name: Capsaicin
Purity: from Capsicum sp., ≥50% (HPLC)
Packaging: 100mg
Price: $64.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: 21750
Product name: Capsaicin
Purity: from Capsicum sp., ≥50% (HPLC)
Packaging: 1g
Price: $315
Updated: 2024/03/01

Sigma-Aldrich

Product number: 12084
Product name: Capsaicin
Purity: analytical standard
Packaging: 10mg
Price: $70.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: 211275
Product name: Capsaicin
Purity: An active constituent of cayenne pepper with excitatory and desensitizing effects on a subset of primary afferent sensory neurons.
Packaging: 100mg
Price: $99.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: 12084
Product name: Capsaicin
Purity: analytical standard
Packaging: 50mg
Price: $247
Updated: 2024/03/01

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Capsaicin Chemical Properties,Usage,Production

Description

Capsaicin is the main chemical that makes chili peppers hot. Capsaicin is an animal repellent that is also used against insects and mites. Capsaicin was first registered for use in the United States in 1962. The U.S. Environmental Protection Agency considers it to be a biochemical pesticide because it is a naturally occurring substance.

The chemical compound capsaicin (8-methyl-N-vanillyl-6-nonenamide) is the active component of chili peppers, which are plants belonging to the genus Capsicum. It is an irritant for mammals, including humans, and produces a sensation of burning in any tissue it comes in contact with. Capsaicin and several related compounds are called capsaicinoids and are produced as a secondary metabolite by chili peppers, probably as deterrents against herbivores. Pure capsaicin is a hydrophobic, colorless, odorless, crystalline to waxy compound.

History

Capsaicin is a naturally occurring substance that is responsible for the burning, pungent sensation associated with the ingestion of hot peppers from the Capsicum genus. The effect elicited by these peppers is at the origin of the name Capsicum, which derives from the Greek kapto, meaning “to bite”.
Hot peppers are a native plant from the American tropics and their use can be traced back to the Aztec and Inca civilizations. The Aztecs named them “chilies” and used them for culinary purposes. After discovery of the New World, chili pods were introduced in Europe and their cultivation expanded to other parts of the globe. Nowadays, hot peppers are found in nearly every country and are an important part of the culinary tradition of many different cultures.
The active component of chili peppers was initially isolated by J. C. Thresh in 1846. The compound was named “capsaicin” and its chemical structure was later determined by E. K. Nelson in 1919. The complete chemical synthesis of 8-methyl-N- vanillyl-6-nonenamide (capsaicin’s IUPAC* name) was reported in 1930 by Spath &Darling. In the 1960’s, Japanese investigators identified additional substances from Capsicum extracts with similar chemical and pharmacological properties that were termed “capsaicinoids”. Currently, this family of chemical analogues includes both natural (homodihydrocapsaicin, dihydrocapsaicin, nordihydrocapsaicin, homocapsaicin and capsaicin) and synthetic (nonivamide) members.

Uses

Capsaicin is what makes chili peppers hot. It is an irritant.for mam- mals, but not for birds. This may be because birds spread the seeds better than mammals. It causes a burning sensation in any mam- malian tissue with which it comes in contact.
Capsaicin is a nonpolar molecule; it dissolves in fats and oils, not in water. This is why water does not take away the burning sensation, but whole milk or other fat-containing liquids or foods will.
As an ingredient in medicines, capsaicin is used to relieve pain from arthritis, muscle aches, and sprains. It is a rubefacient, meaning it dilates blood vessels. The heat effect overwhelms nerves, causing a localized numbing sensation.
Capsaicin is also used in pepper spray.

Application in Particular Diseases

In Osteoarthritis:

Capsaicin, an extract of red peppers that causes release and ultimately depletion of substance P from nerve fibers, has been beneficial in providing pain relief in OA when applied topically over affected joints. It may be used alone or in combination with oral analgesics or NSAIDs.
To be effective, capsaicin must be used regularly, and it may take up to 2 weeks to work. It is well tolerated, but some patients experience temporary burning or stinging at the site of application. Patients should be warned not to get the cream in their eyes or mouth and to wash their hands after application.
Application of the cream, gel, or lotion is recommended four times daily, but tapering to twice-daily application may enhance long-term adherence with adequate pain relief.

Description

Capsaicin has a mild, warm-herbaceous odor and a burning pungent taste (at 10 ppm). It is used in compounded flavors for sauces where the pungent note is desired. This substance is present in several species of Capsicum (Family, Solanaceae). The sensation of pain, accompanied by irritation and inflammation, is due to substance P depletion from sensory (afferent) nerve fibers. These properties are used to study the physiology of pain and the effects as a counterirritant and gastrointestinal stimulant. This substance may be prepared from 3-chloro-2-isopropyltetrahydropyran; biosynthesis from Capsicum frutescens; separation form cis-capsaicin, pelargonic acid vanilamide, and dihydrocapsaicin, reaction of capsaicin.

Description

Capsaicin is a terpene alkaloid that has been found in Capsicum and has diverse biological activities. It induces inward currents in HEK293 cells expressing rat transient receptor potential vanilloid 1 (TRPV1; EC₅₀ = 0.64 μM at neutral pH), an effect that can be blocked by the TRPV1 inhibitor A-425619. Capsaicin (10 and 50 μM) decreases LPS-induced prostaglandin E₂ (PGE₂; ) production, as well as reduces LPS- and IFN-induced nitric oxide (NO) release in isolated mouse peritoneal macrophages. Capsaicin induces substance P release in rat spinal cord slices with an EC₅₀ value of 2.3 μM. It reduces acetylcholine- or phenylquinone-induced writhing (ED₅₀s = 1.33 and 1.38 mg/kg, respectively, s.c.) but has no effect on the latency to paw withdrawal in the hot plate test in mice (ED₅₀ = >20 mg/kg, s.c.). Formulations containing capsaicin have been used in the treatment of nerve pain associated with shingles.

Chemical Properties

Crystalline solid, rectangular plates, or scales. Pungent odor and burning taste.

Chemical Properties

Off-White Crystalline Solid

Chemical Properties

N-(4-Hydroxy-3-methoxybenzyl)-8-methyl-6-nonenamide has a mild, warm-herbaceous odor and burning, pungent taste (10 ppm). It is used in compounded flavors for sauces where the pungent note is desired.

Physical properties

Appearance: crystalline white powder, with highly volatile and pungent odor. Solubility: freely soluble in alcohol, ether, benzene, and chloroform; slightly soluble in carbon disulfide, petroleum, and hydrochloric acid; insoluble in water. Melting point: 65?°C.

Occurrence

The pungent principle in the fruits of various Capsicum species (Solanaceae)

History

In 1816, Christian Friedrich Bucholz (1770–1818) first carried out the purification of capsaicin. He obtained incompletely purified capsaicin and named it “capsaicin” . In 1876, John Clough Thresh (1850–1932) further purified and got pure capsaicin and named it capsaicin. In 1919, Nelson identified the capsaicin structure. In 1930, E.?Spath and S.?F. Darling used chemical synthesis method for the first time to successfully synthesize capsaicin. In 1961, the Japanese chemists S.? Kosuge and Y.? Inagaki isolated similar substances from capsicum and named them capsaicinoids.
More than 14 capsaicin homologues have been found till now, the structures are similar with capsaicin, and the typical structure is H3CO(HO)-C6H3-CH2-NHCO-R, which is only different from R group. Capsaicin is the highest content in chili pepper. Capsaicin and dihydrocapsaicin are the most potent active substances in capsicum. Capsaicin and its analogues have been synthesized in large quantities in practice and can be used not only in medicine but also in agriculture and industry. Although there is a long history of pharmacological and chemical studies on capsaicin, until November 16, 2009, the US Food and Drug Administration (FDA) approved the first containing high concentration capsaicin prescription Qutenza (8% capsaicin) patch for the treatment of postherpetic neuralgia. At present, most countries have capsaicin prescription drugs on market, but clinical indications are limited in the treatment of pain.

Uses

A representative lot is a 5:1 E:Z mixture. It is used as a tool in neurobiological research. Prototype vanilloid receptor agonist. Topical analgesic.

Uses

K channel blocker; multiple sclerosis therapy

Uses

analgesic (topical), depletes Substance P, neurotoxic

Uses

Capsaicin analogue (C175680). It is used as a tool in neurobiological research. Prototype vanilloid receptor agonist. Topical analgesic.

Uses

Capsaicin is used in many topical ointments used to relieve the pain of peripheral neuropathy (treatment of pain in the nerve endings near the surface of the skin).

Indications

Capsaicin (Zostrix) is approved for the relief of pain following herpes zoster infection (postherpetic neuralgia). The drug depletes neurons of substance P, an endogenous neuropeptide that may mediate cutaneous pain. It is applied to affected skin after open lesions have healed. Local irritation is common.

Definition

ChEBI: Capsaicin is a capsaicinoid. It has a role as a non-narcotic analgesic, a voltage-gated sodium channel blocker and a TRPV1 agonist.

General Description

Capsaicin occurs as the active ingredient of hot/red pepper and was first obtained by Thresh in 1846. It is a lipophilic vanilloid compound responsible for the acrid taste of hot peppers.

Biological Activity

Prototypic vanilloid receptor agonist (pEC 50 values are 7.97 and 7.10 at rat and human VR1 receptors respectively). Excites a subset of primary afferent sensory neurons, with subsequent antinociceptive and anti-inflammatory effects. Reversibly inhibits aggregation of platelets. Also available as part of the Vanilloid TRPV1 Receptor Tocriset™ .

Biochem/physiol Actions

Prototype vanilloid receptor agonist. Neurotoxin; activates sensory neurons that give rise to unmyelinated C-fibers, many of which contain substance P. Topical application desensitizes the sensory nerve endings giving a paradoxical antinociceptive effect; systemic administration can be neurotoxic to capsaicin-sensitive cells, especially in newborn animals. Active component of chili peppers.

Pharmacology

Hbgyes, A. (1878) first reported that capsaicin has a strong stimulating effect, which is the first pharmacological study on capsaicin. And then, a serial of pharmacological effects were discovered. The discovery of capsaicin receptor further explains the mechanism of capsaicin. The capsaicin receptor, also known as transient voltage receptor cation channel V1 (TRPV1), is a nonselective ligand-gated cation channel. TRPV1 is widely distributed in the body, mainly in sensory neurons, and can also be activated by heat and friction damage. Studies on the analgesic effect of capsaicin were carried out earlier and more thoroughly. Capsaicin can act on sensory nerve C primary afferent fibers, bind the end of the neuronal TRPV1 receptor. Capsaicin (1?μM) can result in inward calcium influx, cell depolarization, neuronal excitation, and glutamate release. The sustained neuron excitement and then failure can result in analgesic and antipruritic effects. The mutation of the capsaicin receptor can not only induce obesity but also may be associated with the occurrence of diabetes. Capsaicin can activate and recruit brown fat to prevent obesity. Brown fat can produce non-shivering heat in cold environment and participate in energy consumption. A 10–130?mg daily capsaicin can significantly increase the body’s energy and fat consumption. Capsaicin also has a protective effect on the cardiovascular system. Treatment of capsaicin with rats at a dose of 15?mg/kg can not only promote animal blood circulation and strengthen the cardiovascular function but also reduce the blood pressure , the serum cholesterol, and triglyceride levels. The study result of capsaicin on tumor is still controversial. The epidemiology and basic research have suggested that capsaicin can not only be used as a carcino400 gen but also can prevent cancer. It has been shown that capsaicin can induce cancer cell apoptosis, and animal experiments have shown that prolonged use of capsaicin on the skin can induce skin cancer. Capsaicin is able to scavenge free radicals and inhibit oxidative stress. Capsaicin can promote gastric secretion, increase appetite, relieve flatulence, improve digestive function, and also prevent gastrointestinal infection and diarrhea. Capsaicin can improve the performance of sports and anti-fatigue. Capsaicin is capable of thinning lung mucus, in favor of sputum discharging, enhancing lung tissue perfusion, and preventing and treating emphysema. Capsaicin is also beneficial on psoriasis, frostbite, cold, etc. In addition, capsaicin is also used for the paralysis of peripheral nerve function for hypertension treatment. Capsaicin can be absorbed by the intestine and skin and is able to pass through the blood-brain barrier.

Clinical Use

In clinical practice, capsaicin is mainly used for topical administration, such as in the treatment of osteoarthritis and rheumatoid arthritis pain, diabetic nerve pain, pain after surgery, chemotherapy- or radiotherapy-induced oral pain, psoriasis, etc. Capsaicin irritates the mucous membrane to cause sneezing, nose bleeding, coughing, mucus secretion, tears, bronchoconstriction, breathing difficulties, and other symptoms. The main adverse effects of capsaicin preparations are contact dermatitis, skin inflammation or blisters, and in severe situation burn-like lesion.

Anticancer Research

Capsaicin is the major pungent ingredient in red and green chili pepper. It is reportedto induce apoptosis selectively in cancer cells and can suppress the activation ofNF-κB through suppression of NF-κB inhibitor IκBα (Aggarwal and Shishodia 2004). It shows anticancer effects in animal models and suppresses carcinogenesisin colon, skin, lung, tongue, and prostate cancers by altering the metabolism ofcarcinogens. It selectively suppresses the human cancer cell growth of prostate,leukemic, glioma, gastric, and hepatic cancers. It inhibited the tumorigenesis linkedand IL-6-induced activation of STAT-3 and STAT3-regulated gene products likecyclin D1, Bcl-2, Bcl-xL, survivin, and VGEF. It arrests cells in G1 phase andinduces apoptosis (Aggarwal et al. 2008; Clark and Lee 2016).

Synthesis

From 3-chloro-2-isopropyltetrahydropyran; biosynthesis from Capsicum frutescens; separation from cis-capsaicin, pelargonic acid vanillamide and dihydrocapsaicin; reaction of capsaicin

Potential Exposure

Botanical animal and insect repellent used to repel birds, voles, deer, rabbits, squirrels, insects, and attacking dogs. Capsaicin, which is made from the Capsicum red chili pepper can be used indoors to protect carpets and upholstered furniture, and outdoors to protect fruit and vegetable crops, flowers, ornamental plants, shrubbery, trees, and lawns. It is also used in pepper sprays such as MACE, and as an analgesic in creams, lotions and solid sticks to reduce arthritic, postoperative and neuopathic pain, such as shingles. Capsaicin is obtained by grinding dried, ripe Capsicum frutescens L. chili peppers into a fine powder. The oleoresin is derived by distilling the powder in a solvent and evaporating the solvent. The resulting highly concentrated liquid has little odor but has an extremely pungent taste

storage

Room temperature

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Purification Methods

Recrystallise capcaicin from pet ether (b 40-60o), or pet ether/Et2O (9:1). Also purify it by chromatography on neutral Al2O3 (grade V) and elute successively with *C6H6, *C6H6/EtOAc (17:3) then *C6H6/EtOAc (7:3), and distil it at 120o/10-5mm, then repeatedly recrystallise the needles from isopropanol (charcoal). [Crombie et al. J Chem Soc 11025 1955, Bennett & Kirby J Chem Soc(C) 442 1968.] It causes pain and is neurotoxic [Bevan & Szolcsanyi Trends in Pharmacol Sci 11 330 1990, Beilstein 13 IV 2588].

Incompatibilities

Slowly hydrolyzes in water, releasing ammonia and forming acetate salts.

Waste Disposal

Do not discharge into drains or sewers. Dispose of waste material as hazardous waste using a licensed disposal contractor to an approved landfill. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Incineration with effluent gas scrubbing is recommended. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Noncombustible containers should be crushed and buried under more than 40 cm of soil. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office

References

1) Gunthorpe et al. (2002) The diversity in the vanilloid (TRPV) receptor family of ion channels; Trends Pharmacol. Sci. 23 183 2) Van Der Stelt and Di Marzo (2004) Endovanilloids. Putative endogenous ligands of transient receptor potential vanilloid 1 channels; Eur. J. Biochem. 271 1827 3) Perkins and Campbell (1992) Capsazepine reversal of the antinociceptive action of capsaicin in vivo; Br. J. Pharmacol. 107 329 4) Kim et al..(2003) Capsaicin exhibits anti-inflammatory property by inhibiting IkB-a degradation in LPS-stimulated peritoneal macrophages; Cell. Signal., 15 299 5) Di Marzo et al. (2001) Hypolocomotor effects in rats of capsaicin and two long chain capsaicin homologues; Eur. J. Pharmacol., 420 123

Capsaicin Preparation Products And Raw materials

Raw materials

Sodium hydride Methyl 6-bromohexanoate Tetrahydrofuran Trimethyl phosphite Lithium Aluminum Hydride Hydrochloric acid Sodium hydroxide Hydroxylamine hydrochloride Vanillin Thionyl chloride

Preparation Products

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Country: China
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Shanghai Ruji Biology Technology Co., Ltd.

Tel: +86-21-65211385-8001 36031160
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ProdList: 3224
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Shanghai Tauto Biotech Co., Ltd.

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Guangzhou Isun Pharmaceutical Co., Ltd

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Nanjing Sunlida Biological Technology Co., Ltd.

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TargetMol Chemicals Inc.

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Shenzhen Shijingu Technology Co., Ltd

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Cheng Du Pufeide Biotechnology Co., Ltd.

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Chengdu Herbpurify Co.Ltd.

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View Lastest Price from Capsaicin manufacturers

Sinoway Industrial co., ltd.

Product: Capsaicin 404-86-4
Price: US $165.00-35.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 98% up,
Supply Ability: 20 tons
Release date: 2023-12-29

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Capsaicin 404-86-4
Price: US $70.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-04-23

BINBO BIOLOGICAL CO.,LTD

Product: Capsaicin 404-86-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99.8%
Supply Ability: 1000 kg
Release date: 2024-04-15

404-86-4, CapsaicinRelated Search:

Methyl acrylate 2-HYDROXYACETAMIDE (Trifluoromethoxy)benzene m-Anisyl alcohol METHANE Vitamin E CHLOROPHOSPHONAZO III Anisole Methylparaben Kresoxim-methyl Methyl acetate Bensulfuron methyl Methoxyacetic acid Thiophanate-methyl p-Anisidine METSULFURON METHYL trans-Capsaicin-d3 Methyl Capsaicine

(E)-8-METHYL-NON-6-ENOIC ACID 4-HYDROXY-3-METHOXY-BENZYLAMIDE

(E)-CAPSAICIN

(E)-N-([4-HYDROXY-3-METHOXYPHENYL]METHYL)8-METHYL-6-NONEAMIDE

(E)-N-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-8-METHYL-6-NONENAMIDE

CAPSAICIN

CAPSAICINE

CAPSAICIN, NATURAL

FEMA 3404

FEMA 2787

8-METHYL-N-VANILLYL-6-NONENAMIDE*APPROX. 60%

Capsaicin pure

N-Vanillylnonenamide=Nonanoicacidvanillylamide

8-METHYL-N-VANILLYL-6-NONENAMIDE NATUREL

(6E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide

Axsain

Mioton

Zacin

Zostrix

6-Nonenamide, N-(4-hydroxy-3-methoxyphenyl)methyl-8-methyl-, (6E)-

CAPSAICINEXTRACT

CAPSAICIN,NATURAL,USP

CAPSAICIN,USP

(E)-N-[(4-hydroxy-3-methoxy-phenyl)methyl]-8-methyl-non-6-enamide

CAPSAICIN(USP28: 100% CAPSICUM EXTRACT)

8-METHYL-N-VANILLYL-TRANS-6-NONENAMIDE

8-METHYL-N-VANILLYL-6-NONENAMIDE

8-METHYL-N-VANILLYL-6-NONENEAMIDE

N-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-8-METHYL-6E-NONENAMIDE

N-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-8-METHYL-6-NONENAMIDE

TRANS-8-METHYL-N-VANILLYL-6-NONENAMIDE

TRANS-CAPSAICIN

(e)-6-nonenamide

8-METHYL-N-VANILLYL-6-NONENAMIDE 65-70%

(E)-8-Methyl-N-vanillyl-6-nonenamide

6-Nonenamide,N-[(4-hydroxy-3-methoxyphenyl)

methyl]-8-methyl-,(E)-

CAPSAICIN NATURAL 65%

Capsaicin ,98%

(E)-N-[(4-Hydoxy-3-methoxyphenyl)methyl]-8-metyl-6-nonenamide

Capsaicin Solution, 100ppm

Capsaicin,(E)-8-METHYL-NON-6-ENOIC ACID 4-HYDROXY-3-METHOXY-BENZYLAMIDE

Capsaicin (E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide

Capsaicin, (6E)-

ZK-A

Capsaicin, natural extract≥ 97% (Single peak, HPLC)

Capsaicin,(E)-8-Methyl-N-vanillyl-6-nonenamide

hongdenafil,Acetildenafil

Capsaicin, 99%, from Capsicum annuum L.

(e)-6-nonenamid

capsaicin standard

Capsaicin,8-Methyl-N-vanillyl-trans-6-nonenamide

capsaicin(fromoleoresinofcapsicum)plusrelatedcapsaicinoids

n-(4-hydroxy-3-methoxybenzyl-8-methylnon-trans-6-enamide

nci-c56564

trans-n-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-6-nonenamide

(E)-8-Methyl-N-(4-hydroxy-3-methoxybenzyl)-6-nonenamide

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Capsaicin (100 mg)