SUBSTANCE P
- Product Name
- SUBSTANCE P
- CAS No.
- 12769-48-1
- Chemical Name
- SUBSTANCE P
- Synonyms
- RPKPQFFGLM;SUBSTANCE P;RPKPQQFFGLM-NH2;SUBSTANCE P AMIDE;SUBSTANCE P (TYR8);SUBSTANCE P BOVINE;SUBSTANCE P (HUMAN, BOVINE, RAT, MOUSE);SUBSTANCE P, [D-ARG1, D-PRO2, D-TRP7,9, LEU11];ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2;H2N-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET
- CBNumber
- CB6114259
- Molecular Formula
- C63H98N18O13S
- Formula Weight
- 1347.63
- MOL File
- 12769-48-1.mol
SUBSTANCE P Property
- storage temp.
- -20°C
N-Bromosuccinimide Price
- Product number
- J66954
- Product name
- Substance P
- Purity
- reversed sequence
- Packaging
- 5mg
- Price
- $87.7
- Updated
- 2021/12/16
- Product number
- 1156
- Product name
- Substance P
- Packaging
- 5
- Price
- $163
- Updated
- 2021/12/16
- Product number
- 242082
- Product name
- Substance P
- Packaging
- 100mg
- Price
- $269
- Updated
- 2021/12/16
- Product number
- S8000-14J
- Product name
- Substance P [D-Arg1, D-Pro2, D-Trp7,9, Leu11]
- Packaging
- 5mg
- Price
- $336
- Updated
- 2021/12/16
- Product number
- S8000-15A
- Product name
- Substance P
- Packaging
- 1mg
- Price
- $489
- Updated
- 2021/12/16
SUBSTANCE P Chemical Properties,Usage,Production
Uses
Substance P is a neurokinin undecapeptide neurotransmitter and neuromodulator.
Definition
ChEBI: Substance P is a neuropeptide consisting of 11-amino acids. It preferentially activates neurokinin-1 receptors, exterting excitatory effects on central and peripheral neurons and involved in pain transmission. It has a role as a neurotransmitter, a vasodilator agent and a neurokinin-1 receptor agonist. It is a conjugate base of a substance P(3+).
Mechanism of action
Substance P is an 11-amino-acid neuropeptide belonging to the tachykinin family, mediating its biological actions through activation of G protein–coupled tachykinin (neurokinin-1 [NK1]) receptors. Its proposed physiological roles include inflammation, pain, GI and respiratory function, stress responses, and emesis. Substance P is uniquely associated with the monoamine neurotransmitters, 5-HT and NE.
Clinical Use
The 5-HT neurons coexpress substance P, and the firing of NE neurons is modulated by substance P. Preclinical studies have supported a role of the substance P–NK1 receptor system in stress-related disorders, which has guided the antidepressant development of centrally active NK1 receptor antagonists, such as aprepitant. The NK1 antagonists are generally well tolerated and exhibit less nausea and sexual dysfunction than some currently used antidepressants.
SUBSTANCE P Preparation Products And Raw materials
Raw materials
Preparation Products
SUBSTANCE P Suppliers
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