ChemicalBook > CAS DataBase List > SUBSTANCE P

SUBSTANCE P

Product Name
SUBSTANCE P
CAS No.
12769-48-1
Chemical Name
SUBSTANCE P
Synonyms
RPKPQFFGLM;SUBSTANCE P;RPKPQQFFGLM-NH2;SUBSTANCE P AMIDE;SUBSTANCE P (TYR8);SUBSTANCE P BOVINE;SUBSTANCE P (HUMAN, BOVINE, RAT, MOUSE);SUBSTANCE P, [D-ARG1, D-PRO2, D-TRP7,9, LEU11];ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2;H2N-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET
CBNumber
CB6114259
Molecular Formula
C63H98N18O13S
Formula Weight
1347.63
MOL File
12769-48-1.mol
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SUBSTANCE P Property

storage temp. 
-20°C
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J66954
Product name
Substance P
Purity
reversed sequence
Packaging
5mg
Price
$87.7
Updated
2021/12/16
Tocris
Product number
1156
Product name
Substance P
Packaging
5
Price
$163
Updated
2021/12/16
Usbiological
Product number
242082
Product name
Substance P
Packaging
100mg
Price
$269
Updated
2021/12/16
Usbiological
Product number
S8000-14J
Product name
Substance P [D-Arg1, D-Pro2, D-Trp7,9, Leu11]
Packaging
5mg
Price
$336
Updated
2021/12/16
Usbiological
Product number
S8000-15A
Product name
Substance P
Packaging
1mg
Price
$489
Updated
2021/12/16
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SUBSTANCE P Chemical Properties,Usage,Production

Uses

Substance P is a neurokinin undecapeptide neurotransmitter and neuromodulator.

Definition

ChEBI: Substance P is a neuropeptide consisting of 11-amino acids. It preferentially activates neurokinin-1 receptors, exterting excitatory effects on central and peripheral neurons and involved in pain transmission. It has a role as a neurotransmitter, a vasodilator agent and a neurokinin-1 receptor agonist. It is a conjugate base of a substance P(3+).

Mechanism of action

Substance P is an 11-amino-acid neuropeptide belonging to the tachykinin family, mediating its biological actions through activation of G protein–coupled tachykinin (neurokinin-1 [NK1]) receptors. Its proposed physiological roles include inflammation, pain, GI and respiratory function, stress responses, and emesis. Substance P is uniquely associated with the monoamine neurotransmitters, 5-HT and NE.

Clinical Use

The 5-HT neurons coexpress substance P, and the firing of NE neurons is modulated by substance P. Preclinical studies have supported a role of the substance P–NK1 receptor system in stress-related disorders, which has guided the antidepressant development of centrally active NK1 receptor antagonists, such as aprepitant. The NK1 antagonists are generally well tolerated and exhibit less nausea and sexual dysfunction than some currently used antidepressants.

SUBSTANCE P Preparation Products And Raw materials

Raw materials

Preparation Products

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SUBSTANCE P Suppliers

China 13 France 1 Germany 2 Japan 4 Switzerland 1 United Kingdom 2 United States 12 Global 35
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57511
Advantage
58
United States Biological
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--
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--
Email
sales@advtechind.com
Country
United States
ProdList
6106
Advantage
58
Chem-Impex International, Inc.
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--
Country
United States
ProdList
6740
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64
GenScript Corporation
Tel
--
Fax
--
Email
info@genscript.com
Country
United States
ProdList
400
Advantage
77
The Peptide Laboratory
Tel
--
Fax
--
Email
info@peptidelab.com
Country
United States
ProdList
224
Advantage
30
BIOMOL INTERNATIONAL, LP
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--
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--
Email
info@biomol.com
Country
United States
ProdList
1503
Advantage
77
American Peptide Company
Tel
--
Fax
--
Email
sales@americanpeptide.com
Country
United States
ProdList
1718
Advantage
71
SynPep Corporation
Tel
--
Fax
--
Email
sales@synpep.com
Country
United States
ProdList
1943
Advantage
51
AnaSpec, Inc.
Tel
--
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--
Email
service@anaspec.com
Country
United States
ProdList
4872
Advantage
77
Research Plus, Inc.
Tel
--
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Email
respls@aol.com
Country
United States
ProdList
3676
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51
EMD Biosciences, Inc.
Tel
--
Fax
--
Email
technical@calbiochem.com
Country
United States
ProdList
6529
Advantage
66
MP Biomedicals, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6566
Advantage
81

12769-48-1, SUBSTANCE PRelated Search:

H-GLY-LEU-MET-NH2 HCL ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-OME ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-GLY-LYS-ARG SUBSTANCE P MET-LEU-GLY-PHE-PHE-GLN-GLN-PRO-LYS-PRO-ARG-NH2 SUBSTANCE P (7-11) GLY-LEU-MET-NH2 SUBSTANCE P FRAGMENT 8-11 ACETATE SALT REICHSTEIN'S SUBSTANCE 'G',REICHSTEIN'S SUBSTANCE G REICHSTEIN'S SUBSTANCE ''S'',REICHSTEIN'S SUBSTANCE S,REICHSTEIN'S SUBSTANCE 'S' REICHSTEIN'S SUBSTANCE ''H'',REICHSTEIN'S SUBSTANCE H,REICHSTEIN'S SUBSTANCE 'H' REICHSTEIN'S SUBSTANCE M,REICHSTEIN'S SUBSTANCE 'M' REICHSTEIN'S SUBSTANCE S 21-ACETATE REICHSTEIN'S SUBSTANCE 'FA',REICHSTEIN'S SUBSTANCE FA REICHSTEIN'S SUBSTANCE Q REICHSTEIN'S SUBSTANCE 'J',REICHSTEIN'S SUBSTANCE O,REICHSTEIN'S SUBSTANCE ''J'' REICHSTEIN'S SUBSTANCE 'S' 21-ACETATE 3-ETHYLENEKETAL REICHSTEIN'S SUBSTANCE ''C''

  • RPKPQQFFGLM-NH2
  • RPKPQFFGLM
  • SUBSTANCE P (HUMAN, BOVINE, RAT, MOUSE)
  • SUBSTANCE P BOVINE
  • SUBSTANCE P, [D-ARG1, D-PRO2, D-TRP7,9, LEU11]
  • SUBSTANCE P AMIDE
  • SUBSTANCE P
  • SUBSTANCE P (TYR8)
  • H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2
  • H2N-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET
  • ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2
  • 12769-48-1
  • Peptides
  • Tachykinins
  • Biochemicals and Reagents
  • Amino Acids and Peptides
  • Agonist
  • BioChemical