ChemicalBook > CAS DataBase List > Lisinopril

Lisinopril

Product Name
Lisinopril
CAS No.
76547-98-3
Chemical Name
Lisinopril
Synonyms
mk522;CORIC;PRINIL;MK-521;Tensyn;Longes;Cipral;Linvas;mk0521;CARACE
CBNumber
CB6117715
Molecular Formula
C21H31N3O5
Formula Weight
405.49
MOL File
76547-98-3.mol
More
Less

Lisinopril Property

Melting point:
162-165 °C
Boiling point:
666.4±55.0 °C(Predicted)
Density 
1.251±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
H2O: ≥10 mg/mL
form 
solid
pka
2.18±0.10(Predicted)
color 
white
BCS Class
3
CAS DataBase Reference
76547-98-3(CAS DataBase Reference)
More
Less

Safety

Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
TW3589990
Hazardous Substances Data
76547-98-3(Hazardous Substances Data)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H361Suspected of damaging fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
16833
Product name
Lisinopril
Purity
≥98%
Packaging
1g
Price
$70
Updated
2024/03/01
Cayman Chemical
Product number
16833
Product name
Lisinopril
Purity
≥98%
Packaging
5g
Price
$299
Updated
2024/03/01
Cayman Chemical
Product number
16833
Product name
Lisinopril
Purity
≥98%
Packaging
100mg
Price
$11
Updated
2024/03/01
Cayman Chemical
Product number
16833
Product name
Lisinopril
Purity
≥98%
Packaging
500mg
Price
$40
Updated
2024/03/01
Activate Scientific
Product number
AS112353
Product name
Lisinopril
Purity
96%
Packaging
5G
Price
$342
Updated
2021/12/16
More
Less

Lisinopril Chemical Properties,Usage,Production

Description

Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor (IC50 = 1.2 nM). It reduces the formation of endothelin-1 and increases nitric oxide (NO) in human vascular endothelial cells when used at a concentration of 0.1 nM. Lisinopril inhibits the pressor response to angiotensin I in anesthetized rats and dogs (ID50s = 2.3 and 6.5 μg/kg, respectively).

Originator

Acebitor 5,Biddle Sawyer,India

Uses

Lisinopril is an antihypertensive medication.

Uses

Labeled Lisinopril, intended for use as an internal standard for the quantification fo Lisinopril by GC- or LC-mass spectrometry.

Definition

ChEBI: Lisinopril is a dipeptide. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. It contains a L-prolino group and a L-lysine residue.

Manufacturing Process

2-Oxo-4-phenylbutyric acid and t-BOC-L-lysyl-L-proline are condensed in the presence of sodium cyanoborohydride. Essentially all of the t-BOC protecting group is cleaved when the product is absorbed on strong acid ion exchange resin. The crude N-(1-carboxy-3-phenylpropyl)-L-lysyl-L-proline is eluted from the resin with 10% ammonia, freeze dried, and purified by gel filtration chromatography (LH-20). A minute peak for t-BOC protons in the NMR spectrum disappears when the product is treated with ethyl acetate that is 4 N in hydrogen chloride gas. The NMR spectrum of the resulting HCl salt of the product is consistent with structure. The mass spectrum shows a molecular ion at 693 m/e for the tetrasilylated species. Chromatography on XAD-2 resin using 3.5% acetonitrile in 0.1 molar ammonium hydroxide affords N-α-((1S)- 1-carboxy-3-phenylpropyl)-L-lysyl-L-proline. The last peptide can be produced if 2-oxo-4-phenylbutyric acid and N-t-Boc-L-lysyl-L-proline are condensed in the presence of sodium cyanoborohydride. The product is absorbed on strong acid ion exchange resin, and eluted with 2% pyridine in water. Product-rich cuts are stripped to a glass and treated with 4 N HCl in ethylacetate to remove the t-Boc protecting group. The resulting hydrochloride salt is converted to the free base by absorbing on strong acid ion exchange resin and eluting with 2% pyridine in water. Freeze drying of product-rich cuts affords N-α-(1-carboxy-3-phenylpropyl)-L-lysyl-L-proline as a white fluffy solid. The NMR spectrum is consistent with structure. The mass spectrum shows a molecular ion at 549 for the disilylated species. Chromatography affords the desired isomer.

brand name

Prinivil (Merck); Zestril (AstraZeneca).

Therapeutic Function

Antihypertensive

Lisinopril Preparation Products And Raw materials

Raw materials

L-Lysine Trifluoroacetic acid L-Proline

Preparation Products

More
Less

Lisinopril Suppliers

Canada 3 China 136 Europe 2 France 1 Germany 5 India 23 Japan 1 Spain 2 Switzerland 1 United Kingdom 7 United States 26 Global 207
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
zhangsn@titansci.com
Country
China
ProdList
14113
Advantage
59
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9901
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19918
Advantage
55
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3750
Advantage
55
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
Advantage
58
Wuhan DKY Technology Co.,Ltd.
Tel
27-81302488 18007166089
Fax
027-81302088
Email
info@dkybpc.com
Country
China
ProdList
2024
Advantage
58
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9503
Advantage
50
Chengdu RunZeBenTu Chemical Co., Ltd
Tel
028-88469284 18000562381
Email
rzbtsj@163.com
Country
China
ProdList
9958
Advantage
56
Raw material medicin reagent co.,Ltd
Tel
025-57798860
Email
sales@njromanme.com
Country
China
ProdList
4534
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29797
Advantage
68
Hubei widely chemical technology Co., Ltd.
Tel
027-83991130 18627774460
Fax
027-83991130
Email
1718093273@QQ.COM
Country
China
ProdList
1892
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131981
Advantage
58
Wuhan Runzeweiye Technology Co., Ltd.
Tel
027-50779735 15172337137
Fax
027-50779735
Email
runzeweiye999@163.com
Country
China
ProdList
734
Advantage
55
Conier Chem & Pharma Limited
Tel
13368167990
Email
sales@conier.com
Country
China
ProdList
2809
Advantage
58
Wuhan FengyaoTonghui Chemical Products Co., Ltd.
Tel
027-87466105 15377573527
Email
2678564200@qq.com
Country
China
ProdList
17997
Advantage
58
PI & PI BIOTECH INC.
Tel
020-81716320 17788709170
Fax
020-81716319
Email
Sales@pipitech.com
Country
China
ProdList
2649
Advantage
58
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-51831887 15337167856
Fax
027-51837635 QQ1165326703
Email
hubeixinyuanshun@163.com
Country
China
ProdList
10305
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-037163312495,13303845143 13303845143
Fax
QQ3001379618
Email
3001379618@qq.com
Country
China
ProdList
9939
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 13028896684
Email
sales@rrkchem.com
Country
China
ProdList
55791
Advantage
58
TOSUN PHARM
Tel
020-61855200 13326451905
Email
2881290884@qq.com
Country
China
ProdList
7481
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
0551-65418684 +8618949823763
Fax
0086-551-65418684
Email
sales@tnjchem.com
Country
China
ProdList
25363
Advantage
58
sgtlifesciences pvt ltd
Tel
+8617013299288
Email
dj@sgtlifesciences.com
Country
China
ProdList
12382
Advantage
58
Dideu Industries Group Limited
Tel
+86-29-89586680 +86-15129568250
Email
1026@dideu.com
Country
China
ProdList
29118
Advantage
58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
Tel
+86-029-86333380 18829239519
Fax
188 2923 9519
Email
sales06@tgybio.com
Country
China
ProdList
959
Advantage
58
Baoji Guokang Bio-Technology Co., Ltd.
Tel
0917-3909592 13892490616
Fax
09173909592
Email
gksales1@gk-bio.com
Country
China
ProdList
9339
Advantage
58
AFINE CHEMICALS LIMITED
Tel
0571-85134551
Fax
008657185134895
Email
info@afinechem.com
Country
CHINA
ProdList
15377
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-029-89586680 +86-18192503167
Fax
+86-29-88380327
Email
1026@dideu.com
Country
China
ProdList
9271
Advantage
58
Guangzhou Dreampharm Biotechnology Co., Ltd.
Tel
17825480238
Fax
QQ 3008233717
Email
3008233717@qq.com
Country
China
ProdList
9844
Advantage
12
Henan Weituxi Chemical Technology Co., Ltd.
Tel
0371-63284658; 18135795563
Fax
QQ:2885349392
Email
2885349392@qq.com
Country
China
ProdList
10005
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9414
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-61398051 +8613650506873
Email
sales@chemdad.com
Country
China
ProdList
39916
Advantage
58
Wuhan Yuqing Jiaheng Pharmaceutical Co., Ltd.
Tel
027-83855312 17771813295 13377865312
Email
2668571332@qq.com
Country
China
ProdList
2995
Advantage
58
Wuhan Xinru Chemical Co., Ltd.
Tel
15927387915 15337108568
Email
2769903731@qq.com
Country
China
ProdList
3338
Advantage
58
wuhan dingxingtong Chemical Technology Co., Ltd Co., Ltd
Tel
027-59207796 13429867250
Fax
027-59207796
Email
w13429867250@163.com
Country
China
ProdList
1991
Advantage
58
Wuhan canos Technology Co., Ltd
Tel
027-83238443 15327105076
Fax
027-83238443
Email
926254131@qq.com
Country
China
ProdList
3011
Advantage
58
Hubei huizepu Pharmaceutical Technology Co., Ltd
Tel
18507139096
Fax
QQ：2462856504
Email
17762444226@163.com
Country
China
ProdList
646
Advantage
58
Wuhan kemike Biomedical Technology Co., Ltd
Tel
027-87747081 18186681184
Email
1344475572@qq.com
Country
China
ProdList
7243
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
rose.shi@synzest.com
Country
China
ProdList
9287
Advantage
58
Shanghai Botuo Biotechnology Co., LTD
Tel
16621358918
Fax
QQ:402135374
Email
botuopharma888@163.com
Country
China
ProdList
9215
Advantage
58
Wuhan Wiseman Bioengineering Co.,Ltd
Tel
027-59506022 13419526507
Fax
027-59506022
Email
13419526507@163.com
Country
China
ProdList
2935
Advantage
58
Wuhan Hongde Yuexin Pharmaceutical Technology Co., Ltd
Tel
02783850058 15377551550
Fax
027-83850058
Email
whhdyxchem027@sina.com
Country
China
ProdList
2442
Advantage
58
Wuhan Yanzhe Technology Co., Ltd
Tel
15527250409
Fax
QQ：2692360204
Email
wenhaotian12@163.com
Country
China
ProdList
4576
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8141
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44941
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
13675144456
Fax
025-85563444
Email
sean.lv@synzest.com
Country
China
ProdList
10787
Advantage
58
DONBOO AMINO ACID COMPANY
Tel
+8613063595538
Email
donboo@donboo.com
Country
China
ProdList
9365
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44498
Advantage
58
More
Less

View Lastest Price from Lisinopril manufacturers

Hebei Duling International Trade Co. LTD
Product
Lisinopril 76547-98-3
Price
US $60.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 tons
Release date
2023-02-21
Dideu Industries Group Limited
Product
Lisinopril 76547-98-3
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Lisinopril 76547-98-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

76547-98-3, LisinoprilRelated Search:

D-Proline DL-Lysine acetylsalicylate Poly(L-lysine hydrobromide) L-Lysine hydrochloride L-Lysine LISINOPRIL ESTER,LISINOPRIL (ETHYL) ESTER Lisinopril Dihydrate N6-Trrifluoroacetyl-L-lysine(for Lisinopril),N-6-TRIFLUORO ACETYL-L-LYSINE ( LISINOPRIL INTERMEDIATE ) Lisinopril R,S,S-Diketopiperazine N6-TRIFLUOROACETYL-L-LYSINE /INTERMEDIATE OF LISINOPRIL N6-TrifluoroAcetyl-L-Lysine,Lisinopril N∑-BENZYLOXYCARBONYL-L-LYSINYL-L-PROLINE(LISINOPRIL INTERMEDIATE) (R) Lisinopril (S)Lisinopril-D5 LISINOPRIL DIHYDRATE FOR PERFORMANCE TEST Lisinopril S,S,S-Diketopiperazine Lisinopril LISINOPRIL DIKETOPIPERAZINE

  • (S)-1-[(S)-6-AMINO-2-((S)-1-CARBOXY-3-PHENYL-PROPYLAMINO)-HEXANOYL]-PYRROLIDINE-2-CARBOXYLIC ACID
  • TENSOPRIL
  • VIVATEC
  • ZESTRIL
  • mk522
  • PRINIL
  • PRINIVIL
  • n-{n-[(s)-1-carboxy-3-phenylpropyl]-l-lysyl}-l-proline
  • NOVATEC
  • MK-521
  • mk-0521
  • N-(1(S)-Carboxy-3-phenylpropyl)-L-lysyl-L-proline
  • N2-[(S)-1-Carboxy-3-phenylpropyl]-L-lysyl-L-proline
  • Noperten
  • Presiten
  • Prinvil
  • Tensyn
  • Lisinopril
  • N2-[(S)-1-Carboxy-3-phenylpropyl]-L-Lys-L-Pro-OH·2hydrate
  • 1-[N2-[(S)-1-Carboxy-3-phenylpropyl]-L-lysyl]-L-proline
  • Longes
  • N2-[(S)-1-Carboxy-3-phenylpropyl]-L-Lys-L-Pro-OH
  • (S)-Nα-(1-Carboxy-3-phenylpropyl)-Lys-Pro
  • lisinopri
  • Lisinopril EP Impurity G
  • (2S)-1-[(2S)-6-amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxohexyl]-2-pyrrolidinecarboxylic acid
  • Lisinopril, >99%
  • LISINOPRIL (MK-521)
  • LISINOPRIL DIHYDRATE ASSAY STANDARD BP(CRM STANDARD)
  • LISINOPRIL DIHYDRATE BP
  • LISINOPRIL DIHYDRATE BP STANDARD(CRM STANDARD)
  • LISINOPRIL DIHYDRATE EPL
  • LISINOPRIL DIHYDRATE EPL(CRM STANDARD)
  • LISINOPRIL DIHYDRATE IMP. A (EP): (2RS)-2-AMINO-4-PHENYLBUTANOIC ACID MM
  • LISINOPRIL DIHYDRATE IMP. A (EP): (2RS)-2-AMINO-4-PHENYLBUTANOIC ACID MM(CRM STANDARD)
  • LISINOPRIL USP
  • LISINOPRIL USP(CRM STANDARD)
  • Cipral
  • Inopril
  • Linopril
  • Linvas
  • Lisoril
  • Lispril
  • Listril
  • L-Proline, 1-[N2-(1-carboxy-3-phenylpropyl)-L-lysyl]-, (S)-
  • L-Proline, N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl- (9CI)
  • (s)-1-(n(sup2)-(1-carboxy-3-phenylpropyl)-l-lysyl)-l-proline
  • lysinopril
  • mk0521
  • CORIC
  • CARACE
  • ACERBON
  • ALAPRIL
  • Lisinopril USP24,EPIII
  • Lisinopril Dihydrate, 98.0+ % (HPLC)
  • L-Proline, N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-
  • Lisinopril USP/EP/BP
  • (S)-Lisinopril DISCONTINUED