Lisinopril
- Product Name
- Lisinopril
- CAS No.
- 76547-98-3
- Chemical Name
- Lisinopril
- Synonyms
- mk522;CORIC;PRINIL;MK-521;Tensyn;Longes;Cipral;Linvas;mk0521;CARACE
- CBNumber
- CB6117715
- Molecular Formula
- C21H31N3O5
- Formula Weight
- 405.49
- MOL File
- 76547-98-3.mol
Lisinopril Property
- Melting point:
- 162-165 °C
- Boiling point:
- 666.4±55.0 °C(Predicted)
- Density
- 1.251±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- H2O: ≥10 mg/mL
- form
- solid
- pka
- 2.18±0.10(Predicted)
- color
- white
- BCS Class
- 3
- CAS DataBase Reference
- 76547-98-3(CAS DataBase Reference)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- RTECS
- TW3589990
- Hazardous Substances Data
- 76547-98-3(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H361Suspected of damaging fertility or the unborn child
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 16833
- Product name
- Lisinopril
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $70
- Updated
- 2024/03/01
- Product number
- 16833
- Product name
- Lisinopril
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $299
- Updated
- 2024/03/01
- Product number
- 16833
- Product name
- Lisinopril
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $11
- Updated
- 2024/03/01
- Product number
- 16833
- Product name
- Lisinopril
- Purity
- ≥98%
- Packaging
- 500mg
- Price
- $40
- Updated
- 2024/03/01
- Product number
- CS-2443
- Product name
- Lisinopril
- Packaging
- 500mg
- Price
- $80
- Updated
- 2021/12/16
Lisinopril Chemical Properties,Usage,Production
Description
Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor (IC50 = 1.2 nM). It reduces the formation of endothelin-1 and increases nitric oxide (NO) in human vascular endothelial cells when used at a concentration of 0.1 nM. Lisinopril inhibits the pressor response to angiotensin I in anesthetized rats and dogs (ID50s = 2.3 and 6.5 μg/kg, respectively).
Originator
Acebitor 5,Biddle Sawyer,India
Uses
Lisinopril is an antihypertensive medication.
Uses
Labeled Lisinopril, intended for use as an internal standard for the quantification fo Lisinopril by GC- or LC-mass spectrometry.
Definition
ChEBI: Lisinopril is a dipeptide. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor. It contains a L-prolino group and a L-lysine residue.
Manufacturing Process
2-Oxo-4-phenylbutyric acid and t-BOC-L-lysyl-L-proline are condensed in the presence of sodium cyanoborohydride. Essentially all of the t-BOC protecting group is cleaved when the product is absorbed on strong acid ion exchange resin. The crude N-(1-carboxy-3-phenylpropyl)-L-lysyl-L-proline is eluted from the resin with 10% ammonia, freeze dried, and purified by gel filtration chromatography (LH-20). A minute peak for t-BOC protons in the NMR spectrum disappears when the product is treated with ethyl acetate that is 4 N in hydrogen chloride gas. The NMR spectrum of the resulting HCl salt of the product is consistent with structure. The mass spectrum shows a molecular ion at 693 m/e for the tetrasilylated species. Chromatography on XAD-2 resin using 3.5% acetonitrile in 0.1 molar ammonium hydroxide affords N-α-((1S)- 1-carboxy-3-phenylpropyl)-L-lysyl-L-proline. The last peptide can be produced if 2-oxo-4-phenylbutyric acid and N-t-Boc-L-lysyl-L-proline are condensed in the presence of sodium cyanoborohydride. The product is absorbed on strong acid ion exchange resin, and eluted with 2% pyridine in water. Product-rich cuts are stripped to a glass and treated with 4 N HCl in ethylacetate to remove the t-Boc protecting group. The resulting hydrochloride salt is converted to the free base by absorbing on strong acid ion exchange resin and eluting with 2% pyridine in water. Freeze drying of product-rich cuts affords N-α-(1-carboxy-3-phenylpropyl)-L-lysyl-L-proline as a white fluffy solid. The NMR spectrum is consistent with structure. The mass spectrum shows a molecular ion at 549 for the disilylated species. Chromatography affords the desired isomer.
brand name
Prinivil (Merck); Zestril (AstraZeneca).
Therapeutic Function
Antihypertensive
Lisinopril Preparation Products And Raw materials
Raw materials
Preparation Products
Lisinopril Suppliers
- Tel
- --
- Fax
- --
- dpo@fhrt.com
- Country
- Spain
- ProdList
- 11
- Advantage
- 58
- Tel
- --
- Fax
- --
- dpo@fhrt.com
- Country
- Spain
- ProdList
- 15
- Advantage
- 58
View Lastest Price from Lisinopril manufacturers
- Product
- Lisinopril 76547-98-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Lisinopril 76547-98-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- Lisinopril 76547-98-3
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-24