NADA
- Product Name
- NADA
- CAS No.
- 199875-69-9
- Chemical Name
- NADA
- Synonyms
- NADA;AA-DA;ARACHIDONOYLDOPAMIDE;Arachidonyl dopamine;N-arachidonyldopamine;ARACHIDONOYL DOPAMINE;N-ARACHIDONOYLDOPAMINE;NADA (Arachidonoyl dopamine);N-Arachidonoyl Dopamine (NADA);N-ARACHIDONOYL-3-HYDROXYTYRAMINE
- CBNumber
- CB6127354
- Molecular Formula
- C28H41NO3
- Formula Weight
- 439.63
- MOL File
- 199875-69-9.mol
NADA Property
- Boiling point:
- 640.0±55.0 °C(Predicted)
- Density
- 1.023±0.06 g/cm3(Predicted)
- Flash point:
- 14 °C
- storage temp.
- −20°C
- solubility
- Soluble in DMSO (up to 50 mg/ml).
- pka
- 9.79±0.10(Predicted)
- form
- ethanol solution
- color
- Pale yellow
- Sensitive
- Air Sensitive
- Stability:
- Stable for 2 years from date of purchase as supplied. Subject to air oxidation Solutions in DMSO may be stored at -80° under an inert atmosphere for up to 1 month.
Safety
- Hazard Codes
- F,Xi
- Risk Statements
- 11-36/37/38
- Safety Statements
- 16-26-36
- RIDADR
- UN 1170 3/PG 2
- WGK Germany
- 1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H350May cause cancer
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P308+P313IF exposed or concerned: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 90057
- Product name
- N-Arachidonoyl Dopamine
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $54
- Updated
- 2024/03/01
- Product number
- 90057
- Product name
- N-Arachidonoyl Dopamine
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $98
- Updated
- 2024/03/01
- Product number
- 90057
- Product name
- N-Arachidonoyl Dopamine
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $410
- Updated
- 2024/03/01
- Product number
- 90057
- Product name
- N-Arachidonoyl Dopamine
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $643
- Updated
- 2024/03/01
- Product number
- N407790
- Product name
- NADA
- Packaging
- 1mg
- Price
- $85
- Updated
- 2021/12/16
NADA Chemical Properties,Usage,Production
Description
N-Arachidonoyldopamine (199875-69-9) is an endogenous conjugate of arachidonic acid and dopamine.1?May be the “endogenous capsaicin like substance” in the CNS acting at TRPV1 channels, EC50~ 50 nM1. Also acts as a selective cannabinoid CB1 agonist (Ki=0.25 and 15 μM for CB1 and CB2 respectively)2?and results in a distinct signaling profile from any known cannabinoid3. Competitive inhibitor of FAAH and anandamide transport.4. Modulates acute systemic inflammation via non-hematopoietic TRPV1.5
Uses
NADA is a endogenous CB1 agonist, as well as a vanilloid agonist and inhibitor of FAAH and AMT.
Definition
ChEBI: Arachidonoyl dopamine is a fatty amide, a member of catechols, a secondary carboxamide and a N-(fatty acyl)-dopamine. It is functionally related to a dopamine and an arachidonic acid.
Biological Activity
Potent endogenous cannabinoid and vanilloid receptor agonist, with no action at dopamine receptors. Selective for CB 1 over CB 2 receptors (K i values are 0.25 and 12 μ M respectively), and potent agonist at TRPV1 (VR1) receptors (EC 50 ~ 50 nM). Metabolically stable and competitively inhibits FAAH and anandamide transport. Has cannabinoid and vanilloid actions in vivo . Also available as part of the Endocannabinoid Tocriset™ .
IC 50
CB1: 250 nM (Ki); TRPV1: ~50 nM (EC50)
References
[1] SUSAN M. HUANG. An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors[J]. Proceedings of the National Academy of Sciences of the United States of America, 2002, 99 1: 8400-8405. DOI:10.1073/pnas.122196999
[2] T BISOGNO. N-acyl-dopamines: novel synthetic CB(1) cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo.[J]. Biochemical Journal, 2000, 351 Pt 3: 817-824.
[3] WILLIAM J. REDMOND. Identification of N-arachidonoyl dopamine as a highly biased ligand at cannabinoid CB1 receptors[J]. British Journal of Pharmacology, 2015, 173 1: 115-127. DOI:10.1111/bph.13341
[4] LUCIANO DE PETROCELLIS . Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity[J]. FEBS Letters, 2000, 483 1: Pages 52-56. DOI:10.1016/s0014-5793(00)02082-2
[5] SAMIRA K LAWTON. N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1.[J]. Journal of immunology, 2017: 1465-1475. DOI:10.4049/jimmunol.1602151
NADA Preparation Products And Raw materials
Raw materials
Preparation Products
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