POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT

Product Name: POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT
CAS No.: 31852-29-6
Chemical Name: POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT
Synonyms: PIC-K;PolyI：C-K;Poly I：C PotassiuM Salt;POLY[I] POLY[C] POTASSIUM SALT;polyinosinic-polycytidylic acid*potassium;polyinosinic acid/ polycytidylic potassium;Kanamycin-polyI-polyC potassium salt complex;POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT;Polyinosinic - polyeytidylic acid potassium salt;Polyinosinic acid . Polycytidylic acid potassium salt
CBNumber: CB7690095
Molecular Formula: C19H27KN7O16P2*
Formula Weight: 710.500802
MOL File: 31852-29-6.mol

More

Less

POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT Property

storage temp.: −20°C
solubility: Soluble in DMSO; H2O : 10mg/mL
form: lyophilized powder

More

Less

Safety

WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I3036
Product name: Polyinosinic–polycytidylic acid potassium salt
Purity: ≥99% (TLC)
Packaging: 2mg
Price: $138
Updated: 2024/03/01

Sigma-Aldrich

Product number: I3036
Product name: Polyinosinic–polycytidylic acid potassium salt
Purity: ≥99% (TLC)
Packaging: 20mg
Price: $681
Updated: 2024/03/01

Sigma-Aldrich

Product number: P9582
Product name: Polyinosinic–polycytidylic acid potassium salt
Purity: with buffer salts, TLR ligand tested
Packaging: 5mg
Price: $156
Updated: 2024/03/01

Sigma-Aldrich

Product number: P9582
Product name: Polyinosinic–polycytidylic acid potassium salt
Purity: with buffer salts, TLR ligand tested
Packaging: 50mg
Price: $771
Updated: 2024/03/01

Adipogen Life Sciences

Product number: IAX-200-021-5005
Product name: Polyinosinic-polycytidylicacid[Poly(I:C)]Endotoxin-free(sterile)
Purity: ≥99%
Packaging: 5x5mg
Price: $608
Updated: 2021/12/16

More

Less

POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT Chemical Properties,Usage,Production

Uses

Polyinosinic-polycytidylic Acid Potassium Salt triggers apoptosis in some cancer cells.

Uses

(Polyinosinic-polycytidylic acid potassium salt) TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. Polyinosinic–polycytidylic acid (Poly(I) • Poly(C)) is a double-stranded homopolymer used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.

Biological Activity

Transfection of Poly (I:C) into NIT-1 cells has been used as a model of intracellular dsRNA-induced β cell apoptosis. Eighteen hours post transfection, 45% of the cells were apoptotic with an increase in NF-kB, p50/p65 nuclear translocation, and cleavage of caspases 3 and 8, as well as transcriptional induction of caspase 12, Fas, IL-15, and the TNF receptor-associated ligand (TRAIL). It has been suggested th at Poly(I:C) is one of the most appropriate generators of stable mature dendritic cells (DC). These mature DC might generate in vivo effective immune responses after injection due to their ability to secrete bioactive IL-12 after CD40 ligation. Poly (I:C) was used as a potent adjuvant to enhance the specific anti-tumor immune responses against a peptide-based vaccine.

POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT Suppliers

China 69 Switzerland 2 United States 10 Global 81

Hangzhou Meiya Pharmaceutical Co.,ltd.

Tel: 021-33686691 18001850931;
Email: lijh@meiyapharm.com
Country: China
ProdList: 51
Advantage: 58

Beijing Isomersyn Technology CO;LTD

Tel: 010-82954736 13391601435
Email: sales@isomersyn.com
Country: China
ProdList: 3295
Advantage: 57

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Hubei XinyuanShun Chemical Co., Ltd.

Tel: 13971561712, 13995564702, 027-50664929
Fax: 027-50664927
Email: hbeixys2001@163.com
Country: China
ProdList: 3120
Advantage: 55

HBCChem, Inc.

Tel: +1-510-219-6317
Fax: +1-650-486-1361
Email: sales@hbcchem.com
Country: United States
ProdList: 10648
Advantage: 60

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18070
Advantage: 56

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 16166
Advantage: 55

Hubei kangen Pharmaceutical Chemical Co., Ltd

Tel: 15337215803 15337215803
Fax: 027-89771658
Email: 3357312443@qq.com
Country: China
ProdList: 232
Advantage: 56

Wuhu Nuowei Chemical Technology Co., Ltd

Tel: 0553-8233716 18055326116
Email: sales@nuowei-chem.com
Country: China
ProdList: 951
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

More

Less

View Lastest Price from POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT manufacturers

Hangzhou Meiya Pharmaceutical Co Ltd

Product: Polyinosinic-polycytidylic acid potassium salt (PIC-K) 31852-29-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: ≥90.0%
Supply Ability: 10 tons
Release date: 2024-02-06

31852-29-6, POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALTRelated Search:

Aluminum acetylacetonate Ethyl isocyanoacetate COBALT(II) ACETYLACETONATE Ferric acetylacetonate 2,4-PENTANEDIONE, SILVER DERIVATIVE Tosylmethyl isocyanide N-BUTYLISOCYANIDE METHYL ISOCYANOACETATE SALCOMINE PHENYLSELENOL DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Benzyl isocyanide TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Tris(2,4-pentanedionato)chroMiuM(III) TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) TERT-BUTYL ISOCYANIDE Polyinosinic acid

PolyI：C-K

POLY[I] POLY[C] POTASSIUM SALT

POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT

Polyinosinic acid . Polycytidylic acid potassium salt

polyinosinic-polycytidylic acid*potassium

polyinosinic acid/ polycytidylic potassium

Poly I：C PotassiuM Salt

5'-Cytidylic acid homopolymer complex with 5'-inosinic acid homopolyme potassium salt

5'-Cytidylic acid polymers complex with 5'-inosinic acid polymers potassium salt

5'-Inosinic acid homopolymer complex with 5'-cytidylic acid homopolymer potassium salt

Inosinic acid-cytidylic acid polymer complex potassium salt

Kanamycin-polyI-polyC potassium salt complex

5'-Inosinic acid,homopolymer, complex with 5'-cytidylic acid homopolymer (1:1), potassium salt

Polyinosinic - polyeytidylic acid potassium salt

PIC-K

Polyinosinic-polycytidylic acid potassium salt (PIC-K)

31852-29-6

C10H13N4O8PxC9H14N3O8PxxK

BioChemical

Biochemicals and Reagents

Nucleosides, Nucleotides, Oligonucleotides

Synthetic Oligonucleotides and Related Reagents

Biochemicals and Reagents

Biomaterials

Cell Culture

Materials Science

Nucleosides

Nucleotides

Oligonucleotide Polymers and Copolymers

Oligonucleotides

Other adjuvants

Synthetic Oligonucleotides and Related Reagents

Vaccine Adjuvants

Vaccine Production