POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT
- Product Name
- POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT
- CAS No.
- 31852-29-6
- Chemical Name
- POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT
- Synonyms
- PIC-K;PolyI：C-K;Poly I：C PotassiuM Salt;POLY[I] POLY[C] POTASSIUM SALT;polyinosinic-polycytidylic acid*potassium;polyinosinic acid/ polycytidylic potassium;Kanamycin-polyI-polyC potassium salt complex;POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT;Polyinosinic - polyeytidylic acid potassium salt;Polyinosinic acid . Polycytidylic acid potassium salt
- CBNumber
- CB7690095
- Molecular Formula
- C19H27KN7O16P2*
- Formula Weight
- 710.500802
- MOL File
- 31852-29-6.mol
POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT Property
- storage temp.
- −20°C
- solubility
- Soluble in DMSO; H2O : 10mg/mL
- form
- lyophilized powder
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- I3036
- Product name
- Polyinosinic–polycytidylic acid potassium salt
- Purity
- ≥99% (TLC)
- Packaging
- 2mg
- Price
- $143
- Updated
- 2025/07/31
- Product number
- I3036
- Product name
- Polyinosinic–polycytidylic acid potassium salt
- Purity
- ≥99% (TLC)
- Packaging
- 20mg
- Price
- $666.46
- Updated
- 2025/07/31
- Product number
- P9582
- Product name
- Polyinosinic–polycytidylic acid potassium salt
- Purity
- with buffer salts, TLR ligand tested
- Packaging
- 5mg
- Price
- $161
- Updated
- 2025/07/31
- Product number
- P9582
- Product name
- Polyinosinic–polycytidylic acid potassium salt
- Purity
- with buffer salts, TLR ligand tested
- Packaging
- 50mg
- Price
- $798
- Updated
- 2025/07/31
- Product number
- IAX-200-021-5005
- Product name
- Polyinosinic-polycytidylicacid[Poly(I:C)]Endotoxin-free(sterile)
- Purity
- ≥99%
- Packaging
- 5x5mg
- Price
- $608
- Updated
- 2021/12/16
POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT Chemical Properties,Usage,Production
Uses
Polyinosinic-polycytidylic Acid Potassium Salt triggers apoptosis in some cancer cells.
Uses
(Polyinosinic-polycytidylic acid potassium salt) TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. Polyinosinic–polycytidylic acid (Poly(I) • Poly(C)) is a double-stranded homopolymer used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.
Biological Activity
Transfection of Poly (I:C) into NIT-1 cells has been used as a model of intracellular dsRNA-induced β cell apoptosis. Eighteen hours post transfection, 45% of the cells were apoptotic with an increase in NF-kB, p50/p65 nuclear translocation, and cleavage of caspases 3 and 8, as well as transcriptional induction of caspase 12, Fas, IL-15, and the TNF receptor-associated ligand (TRAIL). It has been suggested th at Poly(I:C) is one of the most appropriate generators of stable mature dendritic cells (DC). These mature DC might generate in vivo effective immune responses after injection due to their ability to secrete bioactive IL-12 after CD40 ligation. Poly (I:C) was used as a potent adjuvant to enhance the specific anti-tumor immune responses against a peptide-based vaccine.
in vivo
Polyinosinic-polycytidylic acid potassium (50 μg; i.v.; on days 3, 6, and 9 after tumor inoculation) shows antitumor activity in NOD/SCID immunodeficient mice[1].
| Animal Model: | NOD/SCID immunodeficient mice (1205Lu cells)[1] |
| Dosage: | 50 μg |
| Administration: | I.v.; on days 3, 6, and 9 after tumor inoculation |
| Result: | Reduced the size of metastases and the total amount of tumor tissue, and the level of human DNA was 50% lower in mice. |
IC 50
TLR3
POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT Suppliers
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- Country
- Switzerland
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- Advantage
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- alexis-ch@alexis-corp.com
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View Lastest Price from POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT manufacturers
- Product
- Polyinosinic-polycytidylic acid potassium salt (PIC-K) 31852-29-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- ≥90.0%
- Supply Ability
- 10 tons
- Release date
- 2024-02-06