ChemicalBook > CAS DataBase List > POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT

POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT

Product Name: POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT
CAS No.: 31852-29-6
Chemical Name: POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT
Synonyms: PIC-K;PolyI：C-K;Poly I：C PotassiuM Salt;POLY[I] POLY[C] POTASSIUM SALT;polyinosinic-polycytidylic acid*potassium;polyinosinic acid/ polycytidylic potassium;Kanamycin-polyI-polyC potassium salt complex;POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT;Polyinosinic - polyeytidylic acid potassium salt;Polyinosinic acid . Polycytidylic acid potassium salt
CBNumber: CB7690095
Molecular Formula: C19H27KN7O16P2*
Formula Weight: 710.500802
MOL File: 31852-29-6.mol

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POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT Property

storage temp.: −20°C
solubility: Soluble in DMSO; H2O : 10mg/mL
form: lyophilized powder

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I3036
Product name: Polyinosinic–polycytidylic acid potassium salt
Purity: ≥99% (TLC)
Packaging: 2mg
Price: $143
Updated: 2025/07/31

Sigma-Aldrich

Product number: I3036
Product name: Polyinosinic–polycytidylic acid potassium salt
Purity: ≥99% (TLC)
Packaging: 20mg
Price: $666.46
Updated: 2025/07/31

Sigma-Aldrich

Product number: P9582
Product name: Polyinosinic–polycytidylic acid potassium salt
Purity: with buffer salts, TLR ligand tested
Packaging: 5mg
Price: $161
Updated: 2025/07/31

Sigma-Aldrich

Product number: P9582
Product name: Polyinosinic–polycytidylic acid potassium salt
Purity: with buffer salts, TLR ligand tested
Packaging: 50mg
Price: $798
Updated: 2025/07/31

Adipogen Life Sciences

Product number: IAX-200-021-5005
Product name: Polyinosinic-polycytidylicacid[Poly(I:C)]Endotoxin-free(sterile)
Purity: ≥99%
Packaging: 5x5mg
Price: $608
Updated: 2021/12/16

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POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT Chemical Properties,Usage,Production

Uses

Polyinosinic-polycytidylic Acid Potassium Salt triggers apoptosis in some cancer cells.

Uses

(Polyinosinic-polycytidylic acid potassium salt) TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. Polyinosinic–polycytidylic acid (Poly(I) • Poly(C)) is a double-stranded homopolymer used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.

Biological Activity

Transfection of Poly (I:C) into NIT-1 cells has been used as a model of intracellular dsRNA-induced β cell apoptosis. Eighteen hours post transfection, 45% of the cells were apoptotic with an increase in NF-kB, p50/p65 nuclear translocation, and cleavage of caspases 3 and 8, as well as transcriptional induction of caspase 12, Fas, IL-15, and the TNF receptor-associated ligand (TRAIL). It has been suggested th at Poly(I:C) is one of the most appropriate generators of stable mature dendritic cells (DC). These mature DC might generate in vivo effective immune responses after injection due to their ability to secrete bioactive IL-12 after CD40 ligation. Poly (I:C) was used as a potent adjuvant to enhance the specific anti-tumor immune responses against a peptide-based vaccine.

in vivo

Polyinosinic-polycytidylic acid potassium (50 μg; i.v.; on days 3, 6, and 9 after tumor inoculation) shows antitumor activity in NOD/SCID immunodeficient mice^[1].

Animal Model:	NOD/SCID immunodeficient mice (1205Lu cells)^[1]
Dosage:	50 μg
Administration:	I.v.; on days 3, 6, and 9 after tumor inoculation
Result:	Reduced the size of metastases and the total amount of tumor tissue, and the level of human DNA was 50% lower in mice.

IC 50

TLR3

POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT Suppliers

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View Lastest Price from POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT manufacturers

Hangzhou Meiya Pharmaceutical Co Ltd

Product: Polyinosinic-polycytidylic acid potassium salt (PIC-K) 31852-29-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: ≥90.0%
Supply Ability: 10 tons
Release date: 2024-02-06

31852-29-6, POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALTRelated Search:

Aluminum acetylacetonate Ethyl isocyanoacetate COBALT(II) ACETYLACETONATE Ferric acetylacetonate 2,4-PENTANEDIONE, SILVER DERIVATIVE Tosylmethyl isocyanide N-BUTYLISOCYANIDE METHYL ISOCYANOACETATE SALCOMINE PHENYLSELENOL DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Benzyl isocyanide TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Tris(2,4-pentanedionato)chroMiuM(III) TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) TERT-BUTYL ISOCYANIDE Polyinosinic acid

PolyI：C-K

POLY[I] POLY[C] POTASSIUM SALT

POLYINOSINIC-POLYCYTIDYLIC ACID POTASSIUM SALT

Polyinosinic acid . Polycytidylic acid potassium salt

polyinosinic-polycytidylic acid*potassium

polyinosinic acid/ polycytidylic potassium

Poly I：C PotassiuM Salt

5'-Cytidylic acid homopolymer complex with 5'-inosinic acid homopolyme potassium salt

5'-Cytidylic acid polymers complex with 5'-inosinic acid polymers potassium salt

5'-Inosinic acid homopolymer complex with 5'-cytidylic acid homopolymer potassium salt

Inosinic acid-cytidylic acid polymer complex potassium salt

Kanamycin-polyI-polyC potassium salt complex

5'-Inosinic acid,homopolymer, complex with 5'-cytidylic acid homopolymer (1:1), potassium salt

Polyinosinic - polyeytidylic acid potassium salt

PIC-K

Polyinosinic-polycytidylic acid potassium salt (PIC-K)

31852-29-6

C10H13N4O8PxC9H14N3O8PxxK

BioChemical

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Nucleosides, Nucleotides, Oligonucleotides

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Nucleotides

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