2-Bromo-2'-chloroacetophenone
- Product Name
- 2-Bromo-2'-chloroacetophenone
- CAS No.
- 5000-66-8
- Chemical Name
- 2-Bromo-2'-chloroacetophenone
- Synonyms
- 2-BROMO-1-(2-CHLOROPHENYL)ETHAN-1-ONE;2-CHLOROPHENACYL BROMIDE;)-1-ethanone;2-Bromo-1-(2-chL;BUTTPARK 41\03-52;AKOS BBS-00003974;Tuloterol Impurity 3;Tulobuterol Impurity 1;Tulobuterol Impurity N1;o-Chlorophenacyl bromide
- CBNumber
- CB6129707
- Molecular Formula
- C8H6BrClO
- Formula Weight
- 233.49
- MOL File
- 5000-66-8.mol
2-Bromo-2'-chloroacetophenone Property
- Boiling point:
- 105 °C1 mm Hg(lit.)
- Density
- 1.602 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.5900(lit.)
- Flash point:
- >230 °F
- storage temp.
- 2-8°C
- solubility
- Acetone, Chloroform, Ethyl Acetate, Methanol
- form
- Liquid
- Specific Gravity
- 1.602
- color
- Colorless to pale yellow
- Sensitive
- Lachrymatory
- InChI
- InChI=1S/C8H6BrClO/c9-5-8(11)6-3-1-2-4-7(6)10/h1-4H,5H2
- InChIKey
- WZWWEVCLPKAQTA-UHFFFAOYSA-N
- SMILES
- C(=O)(C1=CC=CC=C1Cl)CBr
- CAS DataBase Reference
- 5000-66-8(CAS DataBase Reference)
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 2922 8/PG 2
- WGK Germany
- 3
- Hazard Note
- Corrosive/Lachrymatory/Keep Cold
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29143900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 594482
- Product name
- 2-Bromo-2′-chloroacetophenone
- Purity
- 95%
- Packaging
- 1g
- Price
- $68.5
- Updated
- 2025/07/31
- Product number
- 594482
- Product name
- 2-Bromo-2′-chloroacetophenone
- Purity
- 95%
- Packaging
- 5g
- Price
- $258
- Updated
- 2025/07/31
- Product number
- C365034
- Product name
- 2’-Chloro-2-bromoacetophenone
- Packaging
- 5g
- Price
- $145
- Updated
- 2021/12/16
- Product number
- C365034
- Product name
- 2’-Chloro-2-bromoacetophenone
- Packaging
- 25g
- Price
- $360
- Updated
- 2021/12/16
- Product number
- FC20014
- Product name
- 2'-Chloro-2-bromoacetophenone
- Packaging
- 50g
- Price
- $500
- Updated
- 2021/12/16
2-Bromo-2'-chloroacetophenone Chemical Properties,Usage,Production
Chemical Properties
Colourless Liquid
Uses
2’-Chloro-2-bromoacetophenone (cas# 5000-66-8) is a compound useful in organic synthesis.
Synthesis
2142-68-9
5000-66-8
The general procedure for the synthesis of 2-bromo-2'-chloroacetophenone from o-chloroacetophenone is as follows: in a reaction system, 1.2 g (10 mmol) of o-chloroacetophenone 1a was mixed and stirred with 0.121 g (0.5 mmol) of Cu(NO3)2-3H2O while an oxygen bulb (ca. 0.5-1 L) was attached. Subsequently, an aqueous 8 mol/L hydrobromic acid solution (1.5 mL, 12 mmol) was slowly added dropwise to the mixture. The reaction mixture was stirred continuously at 70 °C and the reaction progress was monitored by TLC or GC. After completion of the reaction, the mixture was extracted with CH2Cl2. The organic extract was washed sequentially with 5% sodium sulfite solution, saturated sodium bicarbonate solution and water and finally dried with anhydrous magnesium sulfate. The solvent was removed under vacuum and the residue was purified by column chromatography (silica gel as stationary phase, petroleum ether/dichloromethane 3:1 v/v/v) to afford the target product 2-bromo-2'-chloroacetophenone (2a) in a yield of 1.81 g in 91%.
References
[1] Synthetic Communications, 2016, vol. 46, # 2, p. 165 - 168
[2] Patent: US2004/44057, 2004, A1
[3] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 2, p. 692 - 702
[4] Tetrahedron, 1998, vol. 54, # 43, p. 13059 - 13072
[5] Tetrahedron Letters, 2012, vol. 53, # 2, p. 191 - 195
2-Bromo-2'-chloroacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
2-Bromo-2'-chloroacetophenone Suppliers
- Tel
- --
- Fax
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- Country
- Belgium
- ProdList
- 6293
- Advantage
- 73
View Lastest Price from 2-Bromo-2'-chloroacetophenone manufacturers
- Product
- 2-Bromo-2'-chloroacetophenone 5000-66-8
- Price
- US $10.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 99%
- Supply Ability
- 1 ton
- Release date
- 2025-07-01
- Product
- 2-Bromo-2'-chloroacetophenone 5000-66-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10kg/month
- Release date
- 2022-12-28
- Product
- 2-Bromo-2'-chloroacetophenone 5000-66-8
- Price
- US $9.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5tons
- Release date
- 2024-12-03