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Dextromethorphan hydrobromide monohydrate

Product Name
Dextromethorphan hydrobromide monohydrate
CAS No.
6700-34-1
Chemical Name
Dextromethorphan hydrobromide monohydrate
Synonyms
Dextromethorphan HBr monohydrate;DextroMethorphan hydrobroMide hydrate;dextromethorphansigmareference*standard;Dextromethorphan Hydrobromide dextrorotation;(9S,13S,14S)-3-METHOXY-17-METHYLMORPHINAN HYDROBROMIDE, D-3-METHOXY-N-METHYLMORPHINAN HYDROBROMIDE MONOHYDRATE;DMHM;Dextromethorphan hyd;DEXTROMETHORPHAN HBr IP;Morphinan,3-methoxy-17-methyl-;Dextromethorphani Hydrobromidum
CBNumber
CB6131946
Molecular Formula
C18H28BrNO2
Formula Weight
370.33
MOL File
6700-34-1.mol
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Dextromethorphan hydrobromide monohydrate Property

Melting point:
116-119°C
alpha 
[α]D25 +26～+30° (c=1.85, H2O)
Flash point:
11 °C
storage temp. 
Store at RT
solubility 
Sparingly soluble in water, freely soluble in ethanol (96 per cent).
form 
solid
color 
White to Off-White
PH
pH (10g/l, 25℃) : 5.2～6.5
BRN 
6453793
InChIKey
QYPSYPPSHXDFLV-UHFFFAOYSA-N
LogP
1.351 (est)
CAS DataBase Reference
6700-34-1(CAS DataBase Reference)
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Safety

Hazard Codes 
F,T
Risk Statements 
11-23/24/25-39/23/24/25
Safety Statements 
7-16-36/37-45
WGK Germany 
3
HS Code 
3822000002
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D2531
Product name
Dextromethorphan hydrobromide monohydrate
Purity
≥99% (TLC)
Packaging
5g
Price
$80.7
Updated
2024/03/01
Sigma-Aldrich
Product number
D0740000
Product name
Dextromethorphan hydrobromide
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
D0740000
Price
$168
Updated
2024/03/01
Sigma-Aldrich
Product number
1181007
Product name
Dextromethorphan hydrobromide
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$436
Updated
2024/03/01
Cayman Chemical
Product number
13950
Product name
Dextromethorphan (hydrobromide hydrate)
Purity
≥98%
Packaging
50mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
13950
Product name
Dextromethorphan (hydrobromide hydrate)
Purity
≥98%
Packaging
100mg
Price
$61
Updated
2024/03/01
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Dextromethorphan hydrobromide monohydrate Chemical Properties,Usage,Production

Description

Dextromethorphan (DXM) is a dextratrorotatory morphinan with structural similarity to levorphanol, codeine, and morphine. Because of its strong antitussive effects, dextromethorphan is widely used as a cough suppressant. However, it does not provoke opioid activity as is characteristic of several other morphine derivatives. DXM binds to and inhibits NMDA (IC50 = 0.55 μM) and nicotinic receptors (IC50s = 0.7-3.9 μM) and blocks receptor-gated and voltage-gated calcium channels (IC50 = 60 μM) and voltage-gated sodium channels (IC50 = 78 μM). DXM has been used in multimodal analgesic therapies for acute and neuropathic pain.

Chemical Properties

White Solid

Uses

Antitussive;Opioid ligand

Uses

An antitussive drug. Orally active synthetic morphine analog. Analgesic (narcotic). Racemethorphan and levomethorpham are controlled substances (opiates).

Definition

ChEBI: Dextromethorphan hydrobromide is the hydrobromide and monohydrate of the antitussive drug dextromethorphan. It is a hydrate and a hydrobromide. It contains a dextromethorphan.

brand name

Benylin DM (Parke-Davis); Dextromethorphan Hydrobromide OROS Tablets (Ciba-Geigy); Drixoral Cough (Schering-Plough HealthCare); PediaCare 1 (McNeil Consumer); Romilar (Hoffmann-LaRoche-International); St. Joseph Cough Syrup (Schering-Plough HealthCare).

Biological Activity

Non-competitive, low affinity NMDA receptor antagonist. Antitussive, anticonvulsive and neuroprotective agent.

Dextromethorphan hydrobromide monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Dextromethorphan hydrobromide monohydrate Suppliers

Canada 1 China 171 France 1 Germany 2 India 24 Japan 1 Switzerland 1 United Kingdom 7 United States 23 USA 1 Global 232
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View Lastest Price from Dextromethorphan hydrobromide monohydrate manufacturers

Shandong Hanjiang Chemical Co., Ltd
Product
Dextromethorphan hydrobromide monohydrate 6700-34-1
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10T
Release date
2024-01-25
Anhui Yisheng Technology Co., LTD
Product
Dextromethorphan Hydrobromide Monohydrate 6700-34-1
Price
US $50.00-45.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
2 Ton
Release date
2023-01-10
Wuhan Han Sheng New Material Technology Co.，Ltd
Product
Dextromethorphan Hydrobromide 6700-34-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99.54%
Supply Ability
20tons
Release date
2023-04-19

6700-34-1, Dextromethorphan hydrobromide monohydrateRelated Search:

MELIBIOSE Dextromethorphan D-Glucose monohydrate Citric acid monohydrate 3-Isobutyl-1H-pyrazole-5-carboxylic acid 1,4,5,6-TETRAHYDRO-CYCLOPENTAPYRAZOLE-3-CARBOXYLIC ACID Ethyl 3-n-propylpyrazole-5-carboxylate 1-METHYL-4-NITRO-3-PROPYL-1H-PYRAZOLE-5-CARBOXYLIC ACID 3-CYCLOPROPYLPYRAZOLE-5-CARBOXYLIC ACID 1-METHYL-3-PROPYLPYRAZOLE-5-CARBOXYLIC ACID Dextromethorphan Hydrobromide INDAZOLE-3-CARBOXYLIC ACID Hydrogen bromide 4,5,6,7-TETRAHYDRO-1H-INDAZOLE-3-CARBOXYLIC ACID ETHYL ESTER 1H-Pyrazole-3-carboxylicacid,1-methyl-5-propyl-,ethylester(9CI) 2-METHYL-4,5,6,7-TETRAHYDRO-2H-INDAZOLE-3-CARBOXYLIC ACID 4,5,6,7,8,9-HEXAHYDRO-1H-CYCLOOCTAPYRAZOLE-3-CARBOXYLIC ACID 1H-Pyrazole-3-carboxylicacid,1-methyl-5-propyl-(9CI)

  • Dextromethorphan Hydrobromide dextrorotation
  • dextromethorphansigmareference*standard
  • DMHM
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  • 3-Methoxy-17-Methyl-9α,13α,14α-Morphinan HydrobroMide Hydrate
  • d-3-Methoxy-N-MethylMorphinan HydrobroMide Monohydrate
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  • DextroMethorphan hydrobroMide hydrate
  • Morphinan,3-Methoxy-17-Methyl-, hydrobroMide, hydrate (1:1:1), (9a,13a,14a)-
  • (9S,13S,14S)-3-METHOXY-17-METHYLMORPHINAN HYDROBROMIDE, D-3-METHOXY-N-METHYLMORPHINAN HYDROBROMIDE MONOHYDRATE
  • Morphinan,3-methoxy-17-methyl-
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  • DEXTROMETHORPHAN HYDROBROMIDE, PH EUR
  • DEXTROMETHORPHAN HYDROBROMIDE*MONOHYDRAT E USP
  • D-Methorphan hydrobromide monohydrate
  • Morphinan, 3-methoxy-17-methyl-, hydrobromide, monohydrate, (9.alpha.,13.alpha.,14.alpha.)-
  • Dextromethorphan hydrobromicum, (9S,13S,14S)-3-Methoxy-17-methylmorphinan hydrobromide
  • Dextromethorphan monohydrate hydrobromide
  • Dextromethorphan monohydrate hydrobromide, (9S,13S,14S)-3-Methoxy-17-methylmorphinan hydrobromide
  • (9α,13α,14α)-3-Methoxy-17-methylmorphinanhydrobromide
  • Dextromethorphan hydrobromide monohydrate,(9S,13S,14S)-3-Methoxy-17-methylmorphinan hydrobromide, Dextromethorphan hydrobromicum
  • Dextromethorphan hydrobromide monohydrate,(9S,13S,14S)-3-Methoxy-17-methylmorphinan hydrobromide, d-3-Methoxy-N-methylmorphinan hydrobromide monohydrate, Dextromethorphan hydrobromide monohydrate
  • Dextromethorphan Hydrobromide (500 mg) Certified Reference Material (CRM)
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  • (4bS,8aS,9S)-3-methoxy-11-methyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene hydrobromide hydrate
  • Dexmesophane hydrobromide monohydrate
  • Dextromethorphan hydrobromide monohydratec
  • 6700-34-1
  • C18H28BrNO2
  • C18H25NOHBrH2O
  • 37032
  • C18H30BrNO3
  • Allosteric antagonist at NMDA-controlled ion channels; antagonist at voltage-dependent channels
  • Complex Molecules
  • Asymmetric Synthesis
  • Chiral Building Blocks
  • Aromatics
  • Chiral Reagents
  • Heterocycles
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