FMOC-D-Valine
- Product Name
- FMOC-D-Valine
- CAS No.
- 84624-17-9
- Chemical Name
- FMOC-D-Valine
- Synonyms
- FMOC-D-VAL-OH;FMOC-D-VAL;(R)-2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-3-Methylbutanoic acid;FMOC-D-VALINE;FMco-D-Val-OH;N-FMOC-D-VALINE;FMOC-D-VALINE 98%;(R)-N-Fmoc-valine;Fmoc-D-Val-OH,98%;Fmoc-D-Val-OH 98%
- CBNumber
- CB6133511
- Molecular Formula
- C20H21NO4
- Formula Weight
- 339.39
- MOL File
- 84624-17-9.mol
FMOC-D-Valine Property
- Melting point:
- 143-144 °C(lit.)
- alpha
- 17 º (c=1, DMF)
- Boiling point:
- 551.8±33.0 °C(Predicted)
- Density
- 1.229±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), DMF (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 3.90±0.10(Predicted)
- color
- White
- optical activity
- Consistent with structure
- Water Solubility
- Solubility in methanol (almost transparency). Slightly soluble in water.
- BRN
- 6489548
- CAS DataBase Reference
- 84624-17-9(CAS DataBase Reference)
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- HS Code
- 2924 29 70
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- 8.52152
- Product name
- Fmoc-D-Val-OH
- Purity
- Novabiochem?
- Packaging
- 5G
- Price
- $103
- Updated
- 2025/07/31
- Product number
- 8.52152
- Product name
- Fmoc-D-Val-OH
- Purity
- Novabiochem?
- Packaging
- 25g
- Price
- $416
- Updated
- 2025/07/31
- Product number
- 8.52152
- Product name
- Fmoc-D-Val-OH
- Purity
- Novabiochem<SUP>®</SUP>
- Packaging
- 100 g
- Price
- $1000
- Updated
- 2025/07/31
- Product number
- 8.52152
- Product name
- Fmoc-D-Val-OH
- Purity
- Novabiochem<SUP>®</SUP>
- Packaging
- 100 g
- Price
- $1000
- Updated
- 2025/07/31
- Product number
- 8.52152
- Product name
- Fmoc-D-Val-OH
- Purity
- Novabiochem<SUP>®</SUP>
- Packaging
- 1 kg
- Price
- $3370
- Updated
- 2025/07/31
FMOC-D-Valine Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powde
Uses
N-Fmoc-D-valine is an N-Fmoc-protected form of D-Valine (V094200). D-Valine (an isomer of the essential amino acid L-Valine [V094205])exhibited inhibitory effects on fibroblasts that contaminated mammalian kidney cultures, allowing for selective growth epithelial cells. D-Valine is also known for its presence in the structure of Actinomycin D, an antitumour drug. D-Valine is naturally synthesized by Streptomyces antibioticus.
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
Synthesis
640-68-6
28920-43-6
84624-17-9
General procedure for the synthesis of Fmoc-D-valine from D-valine and chloroformic acid-9-fluorenylmethyl ester: A 500 mL three-necked flask was taken, and D-valine (4.5 g, 38.9 mmol), dioxane (40 mL), and 10% aqueous sodium carbonate (100 mL) were added sequentially. The reaction system was placed in an ice bath and mechanical stirring was initiated. A dioxane solution (100 mL) of methyl chloroformate-9-fluorenyl (10.0 g, 38.8 mmol) was prepared in a dropping funnel and slowly added dropwise to the reaction vial. After the dropwise addition was completed, it was gradually brought to room temperature and stirring was continued overnight. After completion of the reaction, 100 mL of water was added to the reaction mixture and extracted three times with 50 mL of ether and the organic phase was discarded. The aqueous phase was cooled in an ice bath, and the pH was adjusted to 1 by slowly adding 1 M dilute hydrochloric acid, followed by extracting the aqueous phase with 50 mL ethyl acetate three times, combining the organic phases and drying with anhydrous magnesium sulfate. The desiccant was removed by filtration and the organic phase was concentrated under reduced pressure to give the white solid product Fmoc-D-valine (12.6 g, 96% yield).
References
[1] Patent: CN106588987, 2017, A. Location in patent: Paragraph 0172; 0173; 0174
[2] Chemistry - A European Journal, 2014, vol. 20, # 21, p. 6526 - 6531
FMOC-D-Valine Preparation Products And Raw materials
Raw materials
Preparation Products
FMOC-D-Valine Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from FMOC-D-Valine manufacturers
- Product
- FMOC-D-Valine 84624-17-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 500kg/month
- Release date
- 2023-01-05
- Product
- FMOC-D-Valine 84624-17-9
- Price
- US $120.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 1000000
- Release date
- 2024-08-15
- Product
- Fmoc-D-Val-OH 84624-17-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T
- Release date
- 2023-12-11