ChemicalBook > CAS DataBase List > FMOC-D-Valine

FMOC-D-Valine

Product Name
FMOC-D-Valine
CAS No.
84624-17-9
Chemical Name
FMOC-D-Valine
Synonyms
FMOC-D-VAL-OH;FMOC-D-VAL;(R)-2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-3-Methylbutanoic acid;FMOC-D-VALINE;FMco-D-Val-OH;N-FMOC-D-VALINE;FMOC-D-VALINE 98%;(R)-N-Fmoc-valine;Fmoc-D-Val-OH,98%;Fmoc-D-Val-OH 98%
CBNumber
CB6133511
Molecular Formula
C20H21NO4
Formula Weight
339.39
MOL File
84624-17-9.mol
More
Less

FMOC-D-Valine Property

Melting point:
143-144 °C(lit.)
alpha 
17 º (c=1, DMF)
Boiling point:
551.8±33.0 °C(Predicted)
Density 
1.229±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), DMF (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
3.90±0.10(Predicted)
color 
White
optical activity
Consistent with structure
Water Solubility 
Solubility in methanol (almost transparency). Slightly soluble in water.
BRN 
6489548
CAS DataBase Reference
84624-17-9(CAS DataBase Reference)
More
Less

Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
2924 29 70
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.52152
Product name
Fmoc-D-Val-OH
Purity
Novabiochem?
Packaging
5G
Price
$103
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52152
Product name
Fmoc-D-Val-OH
Purity
Novabiochem?
Packaging
25g
Price
$416
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52152
Product name
Fmoc-D-Val-OH
Purity
Novabiochem<SUP>&#174;</SUP>
Packaging
100 g
Price
$1000
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52152
Product name
Fmoc-D-Val-OH
Purity
Novabiochem<SUP>&#174;</SUP>
Packaging
100 g
Price
$1000
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52152
Product name
Fmoc-D-Val-OH
Purity
Novabiochem<SUP>&#174;</SUP>
Packaging
1 kg
Price
$3370
Updated
2025/07/31
More
Less

FMOC-D-Valine Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

N-Fmoc-D-valine is an N-Fmoc-protected form of D-Valine (V094200). D-Valine (an isomer of the essential amino acid L-Valine [V094205])exhibited inhibitory effects on fibroblasts that contaminated mammalian kidney cultures, allowing for selective growth epithelial cells. D-Valine is also known for its presence in the structure of Actinomycin D, an antitumour drug. D-Valine is naturally synthesized by Streptomyces antibioticus.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

640-68-6

28920-43-6

84624-17-9

General procedure for the synthesis of Fmoc-D-valine from D-valine and chloroformic acid-9-fluorenylmethyl ester: A 500 mL three-necked flask was taken, and D-valine (4.5 g, 38.9 mmol), dioxane (40 mL), and 10% aqueous sodium carbonate (100 mL) were added sequentially. The reaction system was placed in an ice bath and mechanical stirring was initiated. A dioxane solution (100 mL) of methyl chloroformate-9-fluorenyl (10.0 g, 38.8 mmol) was prepared in a dropping funnel and slowly added dropwise to the reaction vial. After the dropwise addition was completed, it was gradually brought to room temperature and stirring was continued overnight. After completion of the reaction, 100 mL of water was added to the reaction mixture and extracted three times with 50 mL of ether and the organic phase was discarded. The aqueous phase was cooled in an ice bath, and the pH was adjusted to 1 by slowly adding 1 M dilute hydrochloric acid, followed by extracting the aqueous phase with 50 mL ethyl acetate three times, combining the organic phases and drying with anhydrous magnesium sulfate. The desiccant was removed by filtration and the organic phase was concentrated under reduced pressure to give the white solid product Fmoc-D-valine (12.6 g, 96% yield).

References

[1] Patent: CN106588987, 2017, A. Location in patent: Paragraph 0172; 0173; 0174
[2] Chemistry - A European Journal, 2014, vol. 20, # 21, p. 6526 - 6531

FMOC-D-Valine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

FMOC-D-Valine Suppliers

Americas 1 Canada 1 China 269 Europe 2 France 1 Germany 6 India 20 Japan 6 Switzerland 5 United Kingdom 9 United States 49 Global 369
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
Advantage
65
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel
+86-21-54098501
Fax
+86-21-54096319
Email
sales@sinch.com.cn
Country
China
ProdList
11598
Advantage
64
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
Advantage
57
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Aemon Chemical
Tel
0086-755-86198205
Email
acinfo@aemonchem.com
Country
China
ProdList
1931
Advantage
57
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9546
Advantage
55
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Tianjin Chempharmatech Co.,Ltd.
Tel
022-66211079 13212288319
Fax
qq1405432731
Email
sales@chempharmatech.com
Country
China
ProdList
918
Advantage
55
Shanghai BeiZhuo Biotech Co., Ltd.
Tel
021-61119791,13386096464
Fax
021-50190009
Email
bzswkf@foxmail.com
Country
China
ProdList
3921
Advantage
50
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9874
Advantage
55
Shanghai Meishui Chemical Technology Co., Ltd
Tel
021-60549325 18616193163
Fax
021-33250306
Country
China
ProdList
4526
Advantage
56
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9979
Advantage
55
Megchem Co., Ltd.
Tel
+86 (21) 5471-7132
Fax
+86 (21) 5471-6993
Country
China
ProdList
344
Advantage
58
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7778
Advantage
56
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9637
Advantage
58
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883
Fax
0731-82251112
Email
sales@huatengsci.com
Country
China
ProdList
5872
Advantage
58
Suzhou yacoo science co.,Ltd
Tel
0512-87182056 18013166090
Fax
0512-87182056
Email
lingling.qi@yacoo.com.cn
Country
China
ProdList
6295
Advantage
60
NINGBO INNO PHARMCHEM CO.,LTD.
Tel
86-574-27787657
Fax
86-574-27912196
Email
info@dearchem.com
Country
China
ProdList
4613
Advantage
58
Credit-Chem Co., Ltd.
Tel
400-821-5857 021-64326257
Fax
021-64393586 QQ;2798200800
Email
credit-chem@foxmail.com
Country
China
ProdList
5219
Advantage
58
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
14912
Advantage
59
Shanghai Jovan Biochemical Technology Co. Ltd.
Tel
+86-021-61654350
Fax
+86-021-61654350
Email
1245958370@qq.com
Country
China
ProdList
2982
Advantage
50
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9484
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Tianjing Geneston Bio-tech Co.,Ltd.
Tel
022-60131465 18920720807
Fax
022-58558581
Email
zishan_1986@163.com
Country
China
ProdList
743
Advantage
58
Quzhou Rundong Chemical (Technology) Co.
Tel
0570-8789886 18892685668
Fax
0570-8789985
Email
info@rundongchemical.com
Country
China
ProdList
4053
Advantage
60
More
Less

View Lastest Price from FMOC-D-Valine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
FMOC-D-Valine 84624-17-9
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
500kg/month
Release date
2023-01-05
Hebei Fengjia New Material Co., Ltd
Product
FMOC-D-Valine 84624-17-9
Price
US $120.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
1000000
Release date
2024-08-15
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Fmoc-D-Val-OH 84624-17-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T
Release date
2023-12-11

84624-17-9, FMOC-D-ValineRelated Search:

L-Valine Fmoc-Asp(OtBu)-OH 9-Fluorenylmethyl chloroformate Valine Glycine Fmoc-Aib-OH D-Valine Fmoc-Lys(Boc)-OH Fmoc-D-Ile-OH Fmoc-Phe-OH 1,1'-Carbonyldiimidazole L-Fmoc-Aspartic acid alpha-tert-butyl ester Fmoc-D-glutamic acid gamma-tert-butyl ester Fmoc-OSu FMOC-L-Valine Fmoc Carbonyl iron powder NICKEL CARBONYL

  • Fmoc-D-Val-OH >=98.0% (HPLC)
  • (R)-2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-3-Methylbutanoic acid
  • Fmoc-D-valine≥ 99% (HPLC)
  • N-FMOC-D-VALINE
  • 2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-3-methylbutanoic acid
  • (R)-2-(Fmoc-amino)-3-methylbutyric Acid
  • (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methylbutanoic acid
  • N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-D-VALINE
  • N-9-FLUORENYLMETHYLOXYCARBONYL-D-VALINE
  • N-(9-FLUORENYLMETHOXYCARBONYL)-D-VALINE
  • N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-D-VALINE
  • N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-D-VALINE
  • N-ALPHA-FMOC-D-VALINE
  • FMOC-D-VAL-OH
  • FMOC-D-VAL
  • FMOC-D-VALINE
  • 9-FLUORENYLMETHOXYCARBONYL-D-VALINE
  • FMOC-D-VALINE 98%
  • FLUORENYLMETHOXYCARBONYL-D-VALINE(FMOC-D-VAL-OH)
  • FMOC-D-VALINE extrapure
  • N-(9-Fluorenylmethoxycarbonyl)-D-valine, Fmoc-D-valine
  • Nα-(9-Fluorenylmethyloxycarbonyl)-D-valine ,99%
  • 2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-3-methylbutanoic acid
  • Fmoc-D-valine ,99%
  • FMco-D-Val-OH
  • N-Fmoc-D-valine Fmoc-D-Val-OH
  • (9H-Fluoren-9-yl)MethOxy]Carbonyl D-Val-OH
  • FMoc-D-Val-OH ,99%
  • N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-valine&gt
  • D-Valine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
  • FMOC-D-Valine USP/EP/BP
  • (R)-N-Fmoc-valine
  • Fmoc-D-Val-OH,98%
  • Valine Impurity 2 (Fmoc-D-Val-OH)
  • Ensitrelvir Impurity 39
  • Fmoc-<sc>D</sc>-Val-OH
  • N-(9-fluorene methoxycarbonyl)- D-valine
  • Fmoc-D-Val-OH 98%
  • D-Valine, N-FMOC protected
  • 84624-17-9
  • 4624-17-9
  • Valine
  • Peptide Synthesis
  • Specialty Synthesis
  • Amino Acid Derivatives
  • Valine [Val, V]
  • Fmoc-Amino Acids and Derivatives
  • Amino Acids (N-Protected)
  • Biochemistry
  • Fmoc-Amino Acids
  • Fmoc-Amino acid series
  • Fluorenes, Flurenones
  • Amino Acid Derivatives
  • Amino Acids