Hydroxocobalamin

Uses

Product Name: Hydroxocobalamin
CAS No.: 13422-51-0
Chemical Name: Hydroxocobalamin
Synonyms: hydroxycobalamin;axion;HYDROXOCOBALAMINE;hydroxycobalamine;HYDROXOCOBALAMIN VITAMIN B12;axlon;ohb12;cobalex;docclan;docelan
CBNumber: CB6133733
Molecular Formula: C62H90ClCoN13O15P
Formula Weight: 1382.82
MOL File: 13422-51-0.mol

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Hydroxocobalamin Property

Melting point:: >300 °C
storage temp.: 2-8°C
solubility: methanol: 10 mg/mL at 20 °C, clear, dark red
form: Solid
color: Dark Brown to Black
Odor: odorless
Stability:: Hygroscopic
InChIKey: YOZNUFWCRFCGIH-ZKJXODNJNA-K
LogP: -2.812 (est)
EPA Substance Registry System: Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3'-ester with (5,6-dimethyl-1-.alpha.-D-ribofuranosyl-1H-benzimidazole-.kappa.N3) (13422-51-0)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: GG3820000
F: 3-8-10
Hazardous Substances Data: 13422-51-0(Hazardous Substances Data)
Toxicity: LD50 intravenous in mouse: > 50mg/kg

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H1428000
Product name: Hydroxocobalamin
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: h1428000
Price: $220
Updated: 2024/03/01

Cayman Chemical

Product number: 24099
Product name: Hydroxocobalamin
Purity: ≥95%
Packaging: 5mg
Price: $48
Updated: 2024/03/01

Cayman Chemical

Product number: 24099
Product name: Hydroxocobalamin
Purity: ≥95%
Packaging: 10mg
Price: $89
Updated: 2024/03/01

Cayman Chemical

Product number: 24099
Product name: Hydroxocobalamin
Purity: ≥95%
Packaging: 25mg
Price: $210
Updated: 2024/03/01

TRC

Product number: H862820
Product name: Hydroxocobalamin(~90%)
Packaging: 100mg
Price: $180
Updated: 2021/12/16

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Hydroxocobalamin Chemical Properties,Usage,Production

Uses

Hydroxocobalamin is an intermediate in the synthesis of Nitritocobalamin is a useful synthetic intermediate in the synthesis of Hydroxocobalamin Acetate; a physiological analog of vitamin B12 where the CN group is replaced with OH. Exists in aqueous solution as an equilibrium mixture of the hydroxy isomer and the ionic aqua isomer (aquacobalamin). Precursor of the coenzymes methylcobalamin and cobamamide. Coordination Compound. Vitamin (hematopoietic).

Originator

Alpha-Redisol,MSD,US,1962

Uses

Hydroxocobalamin is an intermediate in the synthesis of Nitritocobalamin(N490240) is a useful synthetic intermediate in the synthesis of Hydroxocobalamin Acetate (H826800); a physiological analog of vitamin B12 where the CN group is replaced with OH. Exists in aqueous solution as an equilibrium mixture of the hydroxy isomer and the ionic aqua isomer (aquacobalamin). Precursor of the coenzymes methylcobalamin and cobamamide. Coordination Compound. Vitamin (hematopoietic).

Definition

A form of vitamin B 12.

Manufacturing Process

A solution containing 26.3 mg of vitamin B12 in 15 ml of water was shaken with 78 mg of platinum oxide catalyst and hydrogen gas under substantially atmospheric pressure at 25°C for 20 hours. Hydrogen was absorbed. During the absorption of hydrogen the color of the solution changed from red to brown. The solution was separated from the catalyst and evaporated to dryness in vacuo. The residue was then dissolved in 1 ml of water and then diluted with about 6 ml of acetone.
After standing for several hours a small amount of precipitate (about 2 to 3 mg) was formed and was then separated from the solution. This solution was diluted with an additional 2 ml of acetone and again allowed to stand for several hours. During this time about 4 to 5 mg of noncrystalline precipitate formed. This solid was separated from the solution and an additional 2 ml of acetone was added to the solution. On standing, vitamin B12a began to crystallize in the form of red needles. After standing for 24 hours, the crystalline material was separated, yield 12 mg. By further dilution of the mother liquor with acetone additional crystalline precipitate formed (from US Patent 2,738,302).

Therapeutic Function

Hematopoietic vitamin

Side effects

Hydroxocobalamin is generally a well-tolerated drug. The adverse effects stem from hypersensitivity reactions to cobalt or other components of the hydroxocobalamin injection. These adverse effects include; exanthema (rash), Itching, fever, nausea, dizziness, rigors, and hot flushes. Anaphylaxis is rare.

Hydroxocobalamin Preparation Products And Raw materials

Raw materials

Preparation Products

Hydroxocobalamin Hydrochloride

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Hydroxocobalamin Suppliers

Canada 1 China 149 Europe 2 Germany 2 India 22 South Korea 1 Switzerland 1 United Kingdom 3 United States 22 USA 1 Global 204

AdooQ BioScience, LLC

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BOC Sciences

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BOC Sciences

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Cato Research Chemicals Inc.

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CarboMer, Inc.

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Cayman Chemical Company

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United States Biological

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American International Chemical, Inc.

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SANOFI CHIMIE

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Riedel-de Haen AG

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Matrix Scientific

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Labseeker Inc

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Altan Corporation

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HONEST JOY HOLDINGS LIMITED

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Sciencelab.com, Inc.

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View Lastest Price from Hydroxocobalamin manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: Hydroxocobalamin 13422-51-0
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%min
Supply Ability: 200TON
Release date: 2024-10-30

Hebei Fengjia New Material Co., Ltd

Product: Hydroxocobalamin 13422-51-0
Price: US $120.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000000
Release date: 2024-08-15

Wuhan Boyuan Import & Export Co., LTD

Product: High purity Hydroxocobalamin 13422-51-0
Price: US $25.00-18.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 50000tons
Release date: 2024-04-10

13422-51-0, HydroxocobalaminRelated Search:

Vitamin D3 DL-α-Tocopherol Thiamine nitrate Thiamine chloride Ascorbic Acid Pyridoxine Folic acid Menadione B12 VITAMIN B12 Riboflavin Cocarboxylase Vitamin A Vitamin E HYDROXOCOBALAMIN ACETATE,HYDROXOCOBALAMIN ACETATE SALT Vitamin B12 Vitamin E Vitamin A palmitate Mecobalamin Hydroxocobalamine

alpha-(5,6-dimethylbenzimidazolyl)hydroxocobamide

alphacobione

alpharedisol

axion

axlon

ciplaminh

cobalex

vitaminb(sub12a)

ALPHA-(5,6-DIMETHYLBENZIMIDAZOLYL)HYDROXOCOBAMIDE HYDROCHLORIDE

AQUOCOBALAMIN CHLORIDE

HYDROXYCOBALAMIN HYDROCHLORIDE

HYDROXOCOBALAMIN

HYDROXOCOBALAMINE

HYDROXOCOBALAMINE HYDROCHLORIDE

OH-CBL HCL

VITAMIN B12A

VITAMIN B12A HYDROCHLORIDE

VITAMIN B12B

HYDROXOCOBALAMIN VITAMIN B12

Hydroxocobalamin/VitaminB12Cp2000

α-[5,6-Dimethylbenzimidazolyl] hydroxocobamide

Hydroxocobalam

Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3-ester with (5,6-dimethyl-1-.alpha.-D-ribofuranosyl-1H-benzimidazole-.kappa.N3)

HYDROXOCOBALAMIN,USP

Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-hydroxocobamide

HYDOXOCOBALAMIN

hydroxycobalamin (both acetate and HCl)

Hydroxocobalamin Acetate/Hydroxocobalamin HCL (Vitamin B12)

ALPHAREDISOL (hydroxocobalaMin)

HydroxocobalaMin (VitaMin B12a)

CobinaMide,Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3'-ester with(5,6-diMethyl-1-a-D-ribofuranosyl-1H-benziMidazole-kN3)

High purity Hydroxocobalamin

Hydroxocobalamin/Hydrovit/vitamin B12 CAS NO.13422-51-0

cobinamide,dihydroxide,dihydrogenphosphate(ester),mono(innersalt),3’-e

cobinamide,dihydroxide,dihydrogenphosphate(ester),mono(innersalt),3’-est

cobinamidehydroxidephosphate3’-esterwith5,6-dimethyl-1-alpha-d-ribofuranos

depogamma

docclan

docelan

docelvita

docevita

duradoce

duralta-12

erwith5,6-dimethyl-1-alpha-d-ribofuranosyl-1h-benzimidazole

hydrobamine

hydrocobalamin

hydrogrisevit

hydrovit

hydroxo-cobalami

hydroxocobemine

hydroxycobalamin

hydroxycobalamine

hydroxyvitaminb12

hyxobamine

idrogrisevit

lyovit-h

neo-cytamen

neo-macrabin