ChemicalBook > CAS DataBase List > Doxycycline hyclate

Doxycycline hyclate

Product Name
Doxycycline hyclate
CAS No.
24390-14-5
Chemical Name
Doxycycline hyclate
Synonyms
DOXYCYCLINE HYDRATE;Doxycycline hyclate CRS;Doxycycline Hydrochlocide;Doxycycline Hyclate Soluble Powder;WC2031;DoxycycL;ine hycL;Doxycycline Hc1;Doxycycline API;oxycyclinehyclate
CBNumber
CB6136567
Molecular Formula
C24H31ClN2O9
Formula Weight
526.97
MOL File
24390-14-5.mol
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Doxycycline hyclate Property

Melting point:
206-209?C (dec.)
alpha 
D25 -110° (c = 1 in 0.01N methanolic HCl)
RTECS 
QI8925000
storage temp. 
2-8°C
solubility 
H2O: soluble50mg/mL
form 
Yellow to yellow-green crystalline solid
color 
yellow to greenish-yellow
Water Solubility 
Soluble in water to 50mg/ml. May require warming.Soluble in water, methanol. Sparingly soluble in ethanol. Insoluble in chloroform and ether.
Merck 
14,3440
BRN 
5702728
InChI
InChI=1/C22H24N2O8.C2H6O.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);3H,2H2,1H3;1H/t7-,10+,14+,15-,17-,22-;;/s3
InChIKey
HALQELOKLVRWRI-VDBOFHIQSA-N
SMILES
C(O)C.O[C@@]12C(C(C(=O)N)=C(O)[C@@H](N(C)C)[C@]1([H])[C@H]([C@]1([H])[C@H](C3C=CC=C(O)C=3C(=O)C1=C2O)C)O)=O.Cl |&1:4,12,16,18,19,21,r|
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26
WGK Germany 
3
HS Code 
29413000
Toxicity
LD50 i.p. in rats: 262 mg/kg (Goldenthal)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
BP780
Product name
Doxycycline hyclate
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$268
Updated
2024/03/01
Sigma-Aldrich
Product number
33429
Product name
Doxycycline hyclate
Purity
VETRANAL?, analytical standard
Packaging
100mg
Price
$71.1
Updated
2024/03/01
Sigma-Aldrich
Product number
324385
Product name
Doxycycline, Hyclate - CAS 24390-14-5 - Calbiochem
Purity
A commonly-used broad-spectrum antibiotic.
Packaging
1g
Price
$63.8
Updated
2022/05/15
TCI Chemical
Product number
D4116
Product name
Doxycycline Hyclate
Purity
>97.0%(HPLC)
Packaging
5g
Price
$27
Updated
2024/03/01
TCI Chemical
Product number
D4116
Product name
Doxycycline Hyclate
Purity
>97.0%(HPLC)
Packaging
25g
Price
$75
Updated
2024/03/01
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Doxycycline hyclate Chemical Properties,Usage,Production

Description

Doxycycline Hyclate is the hyclate salt form of doxycycline, is a broad-spectrum tetracycline antibiotic. It inhibits bacterial protein synthesis by binding to ribosomes. Doxycycline also selectively inhibits human matrix metalloproteinase-8 (MMP-8) and MMP-13 over MMP-1 with 50, 60, and 5% inhibition, respectively, when used at a concentration of 30 μM. It can be used as a regulator for inducible gene expression systems where expression depends on either the presence (Tet-On) or absence (Tet-Off) of doxycycline. Formulations containing doxycycline have been used in the treatment of bacterial infections and the prevention of malaria.

Chemical Properties

Doxycycline hyclate is a yellow, hygroscopic crystalline powder, freely soluble in water and in methanol, sparingly soluble in ethanol (96 per cent), it dissolves in solutions of alkali hydroxides and carbonates.

Uses

Doxycycline hyclate is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is used in the treatment of chlamydia, rickettsia, mycoplasma and some spirochete infections. It is also used to inhibit matrix metalloproteinases at subantimicrobial doses. Inhibits matrix metalloproteinases at subantimicrobial doses.

Definition

ChEBI: The hemiethanolate hemihydrate of doxycycline hydrochloride. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chroni obstructive pulmonary disease (COPD), and adult periodontitis.

Application

Doxycycline hyclate is a synthetic oxytetracycline derivative with similar antimicrobial activity. It has been used to eliminate Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and to eliminate Ixodes scapularis ticks. It is a broad spectrum inhibitor used to inhibit matrix metalloproteinases(MMP), such as type 1 collagenase in studies on wound healing and tissue remodeling. Doxycycline hyclate has also been used for the induction of glioma cells and human embryonic kidney 293T cells (HEK293T).

brand name

Atridox (QLT); Doryx (Faulding); Doryx (Warner Chilcott); Doxy (Abraxis); Doxychel Hyclate (Rachelle); Periostat (CollaGenex); Vibramycin (Pfizer);Abadox;Bassado;Bio-tab;Clisemina;Cloran;Cyclidox;Diocimex;Docostyl;Dosil;Dotur;Doxatet;Doxi sergo;Doxicento;Doxifin;Doxilen;Doximycin;Doxiten bio;Doxivis;Doxy-100;Doxy-basan;Doxybiocin;Doxycyl;Doxy-diolan;Doxydyn;Doxyfim;Doxygram;Doxylag;Doxylan;Doxylar;Doxylets;Doxymycin;Doxy-p;Doxytem;Doxy-wolff;Dumoxin;Duradoxal;Esadoxi;Farmodoxi;Ghimadox;Gram-val;Granudoxy;Helvedoclyn;Icladox;Miraclin;Monocline;Monodoxin;Novelciclina;Philcociclina;Roxyne;Semelciclina;Sigadoxin;Solupen;Stamicina;Supracyclin;Tetrasan;Unacil;Vibracina;Vibramicina;Vibramycin hyclate;Vibraveineuse;Vibravenosa;Ximicina;Zadorin.

World Health Organization (WHO)

Doxycycline, a semi-synthetic tetracycline derivative, was first introduced into medicine in 1960 for the treatment of bacterial, rickettsial and amoebic infections. Although allergic manifestations are uncommon, injectable preparations have occasionally resulted in severe anaphylactoid reactions. Clinical features and the fact that asthmatic patients seemed to be particularly at risk lead to suspect a sulfite preservative in the formulation more than doxycycline itself. Rapid administration may also be a factor. Injectable preparations of doxycycline hyclate are included in the WHO Model List of Essential Drugs.

General Description

Doxycycline hyclate belongs to the second generation of tetracycline antibiotics family. Doxycycline hyclate shows minimal side effects upon usage. It is effective for the treatment of recurrent aphthous stomatitis (RAS) and promotes speedy recovery.

Biochem/physiol Actions

Doxycycline hyclate inhibits the inflammatory response to the Lyme Disease Spirochete Borrelia burgdorferi. It is a broad spectrum inhibitor of matrix metalloproteinases in vivo.

storage

+4°C

Mode of action

Tetracycline antimicrobials bind to the bacterial 30S ribosomal subunit interfering with tRNA/mRNA interaction, ultimately inhibiting protein synthesis. Tetracyclines can inhibit the MMP enzyme family and inhibit mitochondrial biogenesis.

Doxycycline hyclate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Doxycycline hyclate manufacturers

HUARONG(GUANGDONG) PHARMACEUTICAL CO.,LTD
Product
Doxycycline hyclate 24390-14-5
Price
US $0.00/kg
Min. Order
25kg
Purity
88%-94%, Vet grade/USP
Supply Ability
200MT
Release date
2024-11-15
Hebei Zhuanglai Chemical Trading Co Ltd
Product
Doxycycline Hyclate 24390-14-5
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-12-04
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Doxycycline hyclate 24390-14-5
Price
US $0.00/Kg/Drum
Min. Order
25KG
Purity
88.0%~94.0%;CP2015
Supply Ability
8000kg/month
Release date
2021-06-04

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