Doxycycline hyclate

ChemicalBook > CAS DataBase List > Doxycycline hyclate

Product Name: Doxycycline hyclate
CAS No.: 24390-14-5
Chemical Name: Doxycycline hyclate
Synonyms: DOXYCYCLINE HYDRATE;Doxycycline hyclate CRS;Doxycycline Hydrochlocide;Doxycycline Hyclate Soluble Powder;WC2031;DoxycycL;ine hycL;Doxycycline Hc1;Doxycycline API;oxycyclinehyclate
CBNumber: CB6136567
Molecular Formula: C24H31ClN2O9
Formula Weight: 526.97
MOL File: 24390-14-5.mol

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Doxycycline hyclate Property

Melting point:: 206-209?C (dec.)
alpha: D25 -110° (c = 1 in 0.01N methanolic HCl)
RTECS: QI8925000
storage temp.: 2-8°C
solubility: H2O: soluble50mg/mL
form: Yellow to yellow-green crystalline solid
color: yellow to greenish-yellow
Water Solubility: Soluble in water to 50mg/ml. May require warming.Soluble in water, methanol. Sparingly soluble in ethanol. Insoluble in chloroform and ether.
Merck: 14,3440
BRN: 5702728
InChI: InChI=1/C22H24N2O8.C2H6O.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);3H,2H2,1H3;1H/t7-,10+,14+,15-,17-,22-;;/s3
InChIKey: HALQELOKLVRWRI-VDBOFHIQSA-N
SMILES: C(O)C.O[C@@]12C(C(C(=O)N)=C(O)[C@@H](N(C)C)[C@]1([H])[C@H]([C@]1([H])[C@H](C3C=CC=C(O)C=3C(=O)C1=C2O)C)O)=O.Cl |&1:4,12,16,18,19,21,r|

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26
WGK Germany: 3
HS Code: 29413000
Toxicity: LD50 i.p. in rats: 262 mg/kg (Goldenthal)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: BP780
Product name: Doxycycline hyclate
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $268
Updated: 2024/03/01

Sigma-Aldrich

Product number: 33429
Product name: Doxycycline hyclate
Purity: VETRANAL?, analytical standard
Packaging: 100mg
Price: $71.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 324385
Product name: Doxycycline, Hyclate - CAS 24390-14-5 - Calbiochem
Purity: A commonly-used broad-spectrum antibiotic.
Packaging: 1g
Price: $63.8
Updated: 2022/05/15

TCI Chemical

Product number: D4116
Product name: Doxycycline Hyclate
Purity: >97.0%(HPLC)
Packaging: 5g
Price: $27
Updated: 2024/03/01

TCI Chemical

Product number: D4116
Product name: Doxycycline Hyclate
Purity: >97.0%(HPLC)
Packaging: 25g
Price: $75
Updated: 2024/03/01

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Doxycycline hyclate Chemical Properties,Usage,Production

Description

Doxycycline Hyclate is the hyclate salt form of doxycycline, is a broad-spectrum tetracycline antibiotic. It inhibits bacterial protein synthesis by binding to ribosomes. Doxycycline also selectively inhibits human matrix metalloproteinase-8 (MMP-8) and MMP-13 over MMP-1 with 50, 60, and 5% inhibition, respectively, when used at a concentration of 30 μM. It can be used as a regulator for inducible gene expression systems where expression depends on either the presence (Tet-On) or absence (Tet-Off) of doxycycline. Formulations containing doxycycline have been used in the treatment of bacterial infections and the prevention of malaria.

Chemical Properties

Doxycycline hyclate is a yellow, hygroscopic crystalline powder, freely soluble in water and in methanol, sparingly soluble in ethanol (96 per cent), it dissolves in solutions of alkali hydroxides and carbonates.

Uses

Doxycycline hyclate is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is used in the treatment of chlamydia, rickettsia, mycoplasma and some spirochete infections. It is also used to inhibit matrix metalloproteinases at subantimicrobial doses. Inhibits matrix metalloproteinases at subantimicrobial doses.

Definition

ChEBI: The hemiethanolate hemihydrate of doxycycline hydrochloride. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chroni obstructive pulmonary disease (COPD), and adult periodontitis.

Application

Doxycycline hyclate is a synthetic oxytetracycline derivative with similar antimicrobial activity. It has been used to eliminate Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and to eliminate Ixodes scapularis ticks. It is a broad spectrum inhibitor used to inhibit matrix metalloproteinases(MMP), such as type 1 collagenase in studies on wound healing and tissue remodeling. Doxycycline hyclate has also been used for the induction of glioma cells and human embryonic kidney 293T cells (HEK293T).

brand name

Atridox (QLT); Doryx (Faulding); Doryx (Warner Chilcott); Doxy (Abraxis); Doxychel Hyclate (Rachelle); Periostat (CollaGenex); Vibramycin (Pfizer);Abadox;Bassado;Bio-tab;Clisemina;Cloran;Cyclidox;Diocimex;Docostyl;Dosil;Dotur;Doxatet;Doxi sergo;Doxicento;Doxifin;Doxilen;Doximycin;Doxiten bio;Doxivis;Doxy-100;Doxy-basan;Doxybiocin;Doxycyl;Doxy-diolan;Doxydyn;Doxyfim;Doxygram;Doxylag;Doxylan;Doxylar;Doxylets;Doxymycin;Doxy-p;Doxytem;Doxy-wolff;Dumoxin;Duradoxal;Esadoxi;Farmodoxi;Ghimadox;Gram-val;Granudoxy;Helvedoclyn;Icladox;Miraclin;Monocline;Monodoxin;Novelciclina;Philcociclina;Roxyne;Semelciclina;Sigadoxin;Solupen;Stamicina;Supracyclin;Tetrasan;Unacil;Vibracina;Vibramicina;Vibramycin hyclate;Vibraveineuse;Vibravenosa;Ximicina;Zadorin.

World Health Organization (WHO)

Doxycycline, a semi-synthetic tetracycline derivative, was first introduced into medicine in 1960 for the treatment of bacterial, rickettsial and amoebic infections. Although allergic manifestations are uncommon, injectable preparations have occasionally resulted in severe anaphylactoid reactions. Clinical features and the fact that asthmatic patients seemed to be particularly at risk lead to suspect a sulfite preservative in the formulation more than doxycycline itself. Rapid administration may also be a factor. Injectable preparations of doxycycline hyclate are included in the WHO Model List of Essential Drugs.

General Description

Doxycycline hyclate belongs to the second generation of tetracycline antibiotics family. Doxycycline hyclate shows minimal side effects upon usage. It is effective for the treatment of recurrent aphthous stomatitis (RAS) and promotes speedy recovery.

Biochem/physiol Actions

Doxycycline hyclate inhibits the inflammatory response to the Lyme Disease Spirochete Borrelia burgdorferi. It is a broad spectrum inhibitor of matrix metalloproteinases in vivo.

storage

+4°C

Mode of action

Tetracycline antimicrobials bind to the bacterial 30S ribosomal subunit interfering with tRNA/mRNA interaction, ultimately inhibiting protein synthesis. Tetracyclines can inhibit the MMP enzyme family and inhibit mitochondrial biogenesis.

Doxycycline hyclate Preparation Products And Raw materials

Raw materials

Preparation Products

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Doxycycline hyclate Suppliers

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View Lastest Price from Doxycycline hyclate manufacturers

Apeloa production Co.,Limited

Product: Doxycycline hyclate 24390-14-5
Price: US $1.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1000
Release date: 2024-05-17

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: Doxycycline hyclate 24390-14-5
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99.8%
Supply Ability: 10000ton
Release date: 2024-04-25

Hebei ZB Gamay Biological Technology Co.,Ltd

Product: Doxycycline hydrochloride 24390-14-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 88%
Supply Ability: 1000kg
Release date: 2022-11-22

24390-14-5, Doxycycline hyclateRelated Search:

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Doxycycline, Hyclate - CAS 24390-14-5 - Calbiochem

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Doxycycline Hyclate (1226003)

6α-Deoxy-5-hydroxytetracycline

(4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hemiethanol dihydrochloride hemihydrate

Azilsartan Impurity 85

Doxycycline (50mg/ml)