ChemicalBook > CAS DataBase List > Doxycycline hyclate

Doxycycline hyclate

Product Name: Doxycycline hyclate
CAS No.: 24390-14-5
Chemical Name: Doxycycline hyclate
Synonyms: DOXYCYCLINE HYDRATE;Doxycycline hyclate CRS;Doxycycline Hydrochlocide;Doxycycline Hyclate Soluble Powder;WC2031;DoxycycL;ine hycL;Doxycycline Hc1;Doxycycline API;oxycyclinehyclate
CBNumber: CB6136567
Molecular Formula: C24H31ClN2O9
Formula Weight: 526.97
MOL File: 24390-14-5.mol

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Doxycycline hyclate Property

Melting point:: 206-209?C (dec.)
alpha: D25 -110° (c = 1 in 0.01N methanolic HCl)
RTECS: QI8925000
storage temp.: 2-8°C
solubility: H2O: soluble50mg/mL
form: Yellow to yellow-green crystalline solid
color: yellow to greenish-yellow
biological source: synthetic
Water Solubility: Soluble in water to 50mg/ml. May require warming.Soluble in water, methanol. Sparingly soluble in ethanol. Insoluble in chloroform and ether.
Merck: 14,3440
BRN: 5702728
InChI: InChI=1/C22H24N2O8.C2H6O.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);3H,2H2,1H3;1H/t7-,10+,14+,15-,17-,22-;;/s3
InChIKey: HALQELOKLVRWRI-VDBOFHIQSA-N
SMILES: C(O)C.O[C@@]12C(C(C(=O)N)=C(O)[C@@H](N(C)C)[C@]1([H])[C@H]([C@]1([H])[C@H](C3C=CC=C(O)C=3C(=O)C1=C2O)C)O)=O.Cl |&1:4,12,16,18,19,21,r|

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26
WGK Germany: 3
HS Code: 29413000
Toxicity: LD50 i.p. in rats: 262 mg/kg (Goldenthal)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0001714
Product name: Doxycycline for system suitability
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 10 mg
Price: $236
Updated: 2025/07/31

Sigma-Aldrich

Product number: D5207
Product name: Doxycycline hyclate
Purity: Suitable for Cell Culture
Packaging: 1 g
Price: $64.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: D5207
Product name: Doxycycline hyclate
Purity: Suitable for Cell Culture
Packaging: 5 g
Price: $169
Updated: 2025/07/31

Sigma-Aldrich

Product number: D5207
Product name: Doxycycline hyclate
Purity: Suitable for Cell Culture
Packaging: 10 g
Price: $271
Updated: 2025/07/31

Sigma-Aldrich

Product number: D3000000
Product name: Doxycycline hyclate
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 50 mg
Price: $236
Updated: 2025/07/31

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Doxycycline hyclate Chemical Properties,Usage,Production

Description

Doxycycline Hyclate is the hyclate salt form of doxycycline, is a broad-spectrum tetracycline antibiotic. It inhibits bacterial protein synthesis by binding to ribosomes. Doxycycline also selectively inhibits human matrix metalloproteinase-8 (MMP-8) and MMP-13 over MMP-1 with 50, 60, and 5% inhibition, respectively, when used at a concentration of 30 μM. It can be used as a regulator for inducible gene expression systems where expression depends on either the presence (Tet-On) or absence (Tet-Off) of doxycycline. Formulations containing doxycycline have been used in the treatment of bacterial infections and the prevention of malaria.

Chemical Properties

Doxycycline hyclate is a yellow, hygroscopic crystalline powder, freely soluble in water and in methanol, sparingly soluble in ethanol (96 per cent), it dissolves in solutions of alkali hydroxides and carbonates.

Uses

Doxycycline hyclate is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is used in the treatment of chlamydia, rickettsia, mycoplasma and some spirochete infections. It is also used to inhibit matrix metalloproteinases at subantimicrobial doses. Inhibits matrix metalloproteinases at subantimicrobial doses.

Definition

ChEBI: The hemiethanolate hemihydrate of doxycycline hydrochloride. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chroni obstructive pulmonary disease (COPD), and adult periodontitis.

Application

Doxycycline hyclate is a synthetic oxytetracycline derivative with similar antimicrobial activity. It has been used to eliminate Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and to eliminate Ixodes scapularis ticks. It is a broad spectrum inhibitor used to inhibit matrix metalloproteinases(MMP), such as type 1 collagenase in studies on wound healing and tissue remodeling. Doxycycline hyclate has also been used for the induction of glioma cells and human embryonic kidney 293T cells (HEK293T).

brand name

Atridox (QLT); Doryx (Faulding); Doryx (Warner Chilcott); Doxy (Abraxis); Doxychel Hyclate (Rachelle); Periostat (CollaGenex); Vibramycin (Pfizer);Abadox;Bassado;Bio-tab;Clisemina;Cloran;Cyclidox;Diocimex;Docostyl;Dosil;Dotur;Doxatet;Doxi sergo;Doxicento;Doxifin;Doxilen;Doximycin;Doxiten bio;Doxivis;Doxy-100;Doxy-basan;Doxybiocin;Doxycyl;Doxy-diolan;Doxydyn;Doxyfim;Doxygram;Doxylag;Doxylan;Doxylar;Doxylets;Doxymycin;Doxy-p;Doxytem;Doxy-wolff;Dumoxin;Duradoxal;Esadoxi;Farmodoxi;Ghimadox;Gram-val;Granudoxy;Helvedoclyn;Icladox;Miraclin;Monocline;Monodoxin;Novelciclina;Philcociclina;Roxyne;Semelciclina;Sigadoxin;Solupen;Stamicina;Supracyclin;Tetrasan;Unacil;Vibracina;Vibramicina;Vibramycin hyclate;Vibraveineuse;Vibravenosa;Ximicina;Zadorin.

World Health Organization (WHO)

Doxycycline, a semi-synthetic tetracycline derivative, was first introduced into medicine in 1960 for the treatment of bacterial, rickettsial and amoebic infections. Although allergic manifestations are uncommon, injectable preparations have occasionally resulted in severe anaphylactoid reactions. Clinical features and the fact that asthmatic patients seemed to be particularly at risk lead to suspect a sulfite preservative in the formulation more than doxycycline itself. Rapid administration may also be a factor. Injectable preparations of doxycycline hyclate are included in the WHO Model List of Essential Drugs.

General Description

Doxycycline hyclate belongs to the second generation of tetracycline antibiotics family. Doxycycline hyclate shows minimal side effects upon usage. It is effective for the treatment of recurrent aphthous stomatitis (RAS) and promotes speedy recovery.

Biochem/physiol Actions

Doxycycline hyclate inhibits the inflammatory response to the Lyme Disease Spirochete Borrelia burgdorferi. It is a broad spectrum inhibitor of matrix metalloproteinases in vivo.

storage

+4°C

Mode of action

Tetracycline antimicrobials bind to the bacterial 30S ribosomal subunit interfering with tRNA/mRNA interaction, ultimately inhibiting protein synthesis. Tetracyclines can inhibit the MMP enzyme family and inhibit mitochondrial biogenesis.

References

[1] WILLIAMSON G M. The in vitro activity of Vibramycin (Doxycycline).[J]. Chemotherapia, 1968, 13: Suppl:1-20. DOI: 10.1159/000220576
[2] MICHAEL O. GRIFFIN Francisco J V Guillermo Ceballos. Tetracycline compounds with non-antimicrobial organ protective properties: Possible mechanisms of action[J]. Pharmacological research, 2011, 63 2: Pages 102-107. DOI: 10.1016/j.phrs.2010.10.004
[3] CHOPRA I. Tetracycline analogs whose primary target is not the bacterial ribosome.[J]. Antimicrobial Agents and Chemotherapy, 1994, 38 4: 637-640. DOI: 10.1128/aac.38.4.637
[4] GERALD N. SMITH JR. Specificity of inhibition of matrix metalloproteinase activity by doxycycline: Relationship to structure of the enzyme[J]. Arthritis & Rheumatology, 2001, 42 6: 1140-1146. DOI: 10.1002/1529-0131(199906)42:6<1140::aid-anr10>3.0.co;2-7
[5] D J GOULD. A novel doxycycline inducible autoregulatory plasmid which displays ‘on’/‘off’ regulation suited to gene therapy applications[J]. Gene Therapy, 2001, 7 24: 2061-2070. DOI: 10.1038/sj.gt.3301354
[6] ZHIJIE LI. Simple piggyBac transposon-based mammalian cell expression system for inducible protein production.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2013: 5004-5009. DOI: 10.1073/pnas.1218620110

Doxycycline hyclate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Doxycycline hyclate manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Doxycycline hyclate 24390-14-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98
Supply Ability: 10000KGS
Release date: 2025-12-01

Wuhan Fortuna Chemical Co.,Ltd

Product: Doxycycline hyclate 24390-14-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 2000KG
Release date: 2025-08-30

Watson Biotechnology Co.,Ltd

Product: Doxycycline Hyclate 24390-14-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20MT
Release date: 2025-07-24

24390-14-5, Doxycycline hyclateRelated Search:

Oxytetracycline hydrochloride 4-Dimethylaminopyridine Methoxyammonium chloride 6-Aminocaproic acid D-Glucosamine hydrochloride 4-Dimethylaminobenzoic acid Glycine 3-Dimethylaminopropylamine Oxytetracycline dihydrate 1,4-Dioxane CHLOROPHOSPHONAZO III Topotecan hydrochloride ALTRENOGEST Oxytetracycline Triethylamine hydrochloride Pyridine hydrochloride 4-Dimethylaminobenzaldehyde Tris(hydroxymethyl)aminomethane

4-(DIMETHYLAMINO)-1,4,4 ALPHA,5,5 ALPHA,6,11,12 ALPHA-OCTAHYDRO-3,5,10,12,12 ALPHA-PENTAHYDROXY-6-METHYL-1,11-DIOXO-2-NAPHTHACENECARBOXAMIDE, MONOHYDRATE

4-(DIMETHYLAMINO)-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-2-NA

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(4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamidehydrochloride

Doxycycline Hydrochlocide

Doxycycline Hc1

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, (4S,4aR,5S,5aR,6R,12aS)-, compd. with ethanol (2:1), monohydrate

Doxycycline Hyclate / Monohydrate

2-(Amino-hydroxy-methylidene)-4-dimethylamino-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione hydrochloride hemiethanolate

Doxycycline hyclate

Doxycycline hydrochloride hemiethanolate

DOXYCYCLINE HYCLATE, =98% (HPLC)

4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydr

Doxycycline for system suitability

Hydrochloride hemiethanolate hemihydrate

Doxycycline Hyclate/HCL

(4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)- 3,5,10,12,12a-pentahydroxy- 6-methyl- 1,11-dioxo- 1,4,4a,5,5a,6,11,12a-octahydrotetracene- 2-carboxamide hydrochloride hemiethanolate hemihydrate

Doxycycline, Hyclate - CAS 24390-14-5 - Calbiochem

Doxycycline hyclate, ≥98%

Doxycycline hyclate, ≥94%

WC2031

Doxycycline Hyclate (200 mg)J0E174859ug/mg(ai)

Doxycycline Hyclate (200 mg)

Doxycycline HCl DISCONTINUED Replaced by D5897

(4S,4aR,5S,5aR,6R,12aS)-4-(DiMethylaMino)-1,4,4a,5,5a,6,11,12a-octahydro -3,5,10,12,12a-pentahydroxy-6-Methyl-1,11-dioxo-

Doxycycline API

Doxycycline hyclate COS

DOXYCYCLINE HYDRATE

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, hydrochloride, (4S,4aR,5S,5aR,6R,12aS)-, compd. with ethanol, hydrate (2:2:1:1)

Doxycycline hyclate Solution, 100ppm

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Doxycycline hyclate, BP

Doxycycline hydrochloride hemiethanolate hemihydrate, Antibiotic for Culture Media Use Only

Doxycycline hyclate CRS

DoxycyclineHyclate&gt

Doxycycline for system suitability CRS

DoxycycL

ine hycL

Doxycline Hydrochloride

(2E,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione

Doxycycline Hydrochloride?I

oxycyclinehyclate

Doxycycline hyclate USP/EP/BP

(4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide compound with ethanol (2:1) dihydrochloride hydrate

Doxycycline D2 Hyclate majorQ: What is Doxycycline D2 Hyclate major Q: What is the CAS Number of Doxycycline D2 Hyclate major Q: What is the storage condition of Doxycycline D2 Hyclate major Q: What are the applications of Doxycycline D2 Hyclate major

Doxycycline D5 HyclateQ: What is Doxycycline D5 Hyclate Q: What is the CAS Number of Doxycycline D5 Hyclate

Doxycycline for system suitability (Y0001714)Q: What is Doxycycline for system suitability (Y0001714) Q: What is the CAS Number of Doxycycline for system suitability (Y0001714)

Doxycycline HyclateQ: What is Doxycycline Hyclate Q: What is the CAS Number of Doxycycline Hyclate Q: What is the storage condition of Doxycycline Hyclate Q: What are the applications of Doxycycline Hyclate

Doxycycline-D4-Hyclate

Doxycycline hyclate (DXH) for biochemistry & microbiology

Doxycycline Hyclate (1226003)

6α-Deoxy-5-hydroxytetracycline

(4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hemiethanol dihydrochloride hemihydrate

Doxycycline (50mg/ml)

DOXYCYCLINE HYCLATE 50% W/W PELLETS