3-Bromo-2,6-difluoropyridine
- Product Name
- 3-Bromo-2,6-difluoropyridine
- CAS No.
- 80392-79-6
- Chemical Name
- 3-Bromo-2,6-difluoropyridine
- Synonyms
- 3-Bromo-2,6-difluoropyridine;Pyridine, 3-bromo-2,6-difluoro-;3-Bromo-2,6-difluoropyridine ISO 9001：2015 REACH
- CBNumber
- CB61471182
- Molecular Formula
- C5H2BrF2N
- Formula Weight
- 193.98
- MOL File
- 80392-79-6.mol
3-Bromo-2,6-difluoropyridine Property
- Boiling point:
- 180.9±35.0 °C(Predicted)
- Density
- 1.808±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -8.45±0.10(Predicted)
- form
- liquid
- color
- Yellow
- InChI
- InChI=1S/C5H2BrF2N/c6-3-1-2-4(7)9-5(3)8/h1-2H
- InChIKey
- GLWVPTDEVHPILQ-UHFFFAOYSA-N
- SMILES
- C1(F)=NC(F)=CC=C1Br
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B997228
- Product name
- 3-Bromo-2,6-difluoropyridine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC500796
- Product name
- 3-Bromo-2,6-difluoropyridine
- Packaging
- 1g
- Price
- $56
- Updated
- 2021/12/16
- Product number
- 3H32-B-0B
- Product name
- 3-Bromo-2,6-difluoropyridine
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 043661
- Product name
- 3-Bromo-2,6-difluoropyridine
- Packaging
- 250mg
- Price
- $18
- Updated
- 2021/12/16
- Product number
- 087201
- Product name
- 3-Bromo-2,6-difluoropyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $29
- Updated
- 2021/12/16
3-Bromo-2,6-difluoropyridine Chemical Properties,Usage,Production
Uses
3-Bromo-2,6-difluoropyridine is mainly used as an intermediate in organic synthesis, especially in medicinal chemistry for the synthesis of biologically active compounds.
Synthesis
866755-20-6
80392-79-6
GENERAL METHOD: To a solution of 2,6-dichloro-3-bromopyridine (4.70 g, 20.7 mmol) in dimethyl sulfoxide (DMSO, 103 mL) was added cesium fluoride (12.6 g, 82.9 mmol) at room temperature. The reaction mixture was stirred in air at 80 °C for 8 hours. After completion of the reaction, the mixture was poured into room temperature water and extracted with ether (Et2O). The organic layer was separated, washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under reduced pressure (400 Torr, 40°C). Purification of the residue by column chromatography (silica gel, hexane solution of ethyl acetate as eluent) afforded 3-bromo-2,6-difluoropyridine (2.58 g, 64% yield) as a colorless oil.1H NMR (CDCl3) δ: 6.79 (1H, dd, J = 8.3, 3.0 Hz), 8.03 (1H, ddd, J = 8.4, 8.4, 7.0 Hz).19F NMR (CDCl3) δ: -69.3 Hz, -63.8 Hz.Compounds 4B-8B were prepared according to the method similar to 3B.
References
[1] Tetrahedron Letters, 2015, vol. 56, # 44, p. 6043 - 6046
3-Bromo-2,6-difluoropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Bromo-2,6-difluoropyridine manufacturers
- Product
- 3-Bromo-2,6-difluoropyridine 80392-79-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-25