ChemicalBook > CAS DataBase List > 3-Bromo-2,6-difluoropyridine

3-Bromo-2,6-difluoropyridine

Product Name
3-Bromo-2,6-difluoropyridine
CAS No.
80392-79-6
Chemical Name
3-Bromo-2,6-difluoropyridine
Synonyms
3-Bromo-2,6-difluoropyridine;Pyridine, 3-bromo-2,6-difluoro-;3-Bromo-2,6-difluoropyridine ISO 9001：2015 REACH
CBNumber
CB61471182
Molecular Formula
C5H2BrF2N
Formula Weight
193.98
MOL File
80392-79-6.mol
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3-Bromo-2,6-difluoropyridine Property

Boiling point:
180.9±35.0 °C(Predicted)
Density 
1.808±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-8.45±0.10(Predicted)
form 
liquid
color 
Yellow
InChI
InChI=1S/C5H2BrF2N/c6-3-1-2-4(7)9-5(3)8/h1-2H
InChIKey
GLWVPTDEVHPILQ-UHFFFAOYSA-N
SMILES
C1(F)=NC(F)=CC=C1Br
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B997228
Product name
3-Bromo-2,6-difluoropyridine
Packaging
50mg
Price
$45
Updated
2021/12/16
Oakwood
Product number
043661
Product name
3-Bromo-2,6-difluoropyridine
Packaging
250mg
Price
$18
Updated
2021/12/16
Matrix Scientific
Product number
087201
Product name
3-Bromo-2,6-difluoropyridine
Purity
98%
Packaging
1g
Price
$29
Updated
2021/12/16
Oakwood
Product number
043661
Product name
3-Bromo-2,6-difluoropyridine
Packaging
1g
Price
$29
Updated
2021/12/16
Apolloscientific
Product number
PC500796
Product name
3-Bromo-2,6-difluoropyridine
Packaging
1g
Price
$56
Updated
2021/12/16
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3-Bromo-2,6-difluoropyridine Chemical Properties,Usage,Production

Uses

3-Bromo-2,6-difluoropyridine is mainly used as an intermediate in organic synthesis, especially in medicinal chemistry for the synthesis of biologically active compounds.

Synthesis

866755-20-6

80392-79-6

GENERAL METHOD: To a solution of 2,6-dichloro-3-bromopyridine (4.70 g, 20.7 mmol) in dimethyl sulfoxide (DMSO, 103 mL) was added cesium fluoride (12.6 g, 82.9 mmol) at room temperature. The reaction mixture was stirred in air at 80 °C for 8 hours. After completion of the reaction, the mixture was poured into room temperature water and extracted with ether (Et2O). The organic layer was separated, washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under reduced pressure (400 Torr, 40°C). Purification of the residue by column chromatography (silica gel, hexane solution of ethyl acetate as eluent) afforded 3-bromo-2,6-difluoropyridine (2.58 g, 64% yield) as a colorless oil.1H NMR (CDCl3) δ: 6.79 (1H, dd, J = 8.3, 3.0 Hz), 8.03 (1H, ddd, J = 8.4, 8.4, 7.0 Hz).19F NMR (CDCl3) δ: -69.3 Hz, -63.8 Hz.Compounds 4B-8B were prepared according to the method similar to 3B.

References

[1] Tetrahedron Letters, 2015, vol. 56, # 44, p. 6043 - 6046

3-Bromo-2,6-difluoropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Bromo-2,6-difluoropyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
3-Bromo-2,6-difluoropyridine 80392-79-6
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-25

80392-79-6, 3-Bromo-2,6-difluoropyridineRelated Search:

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  • 3-Bromo-2,6-difluoropyridine
  • Pyridine, 3-bromo-2,6-difluoro-
  • 3-Bromo-2,6-difluoropyridine ISO 9001：2015 REACH
  • 80392-79-6