2-Bromo-5-chloro-4-fluoroaniline
- Product Name
- 2-Bromo-5-chloro-4-fluoroaniline
- CAS No.
- 85462-59-5
- Chemical Name
- 2-Bromo-5-chloro-4-fluoroaniline
- Synonyms
- BroMo-5-chloro-4-fluoroaniline;2-Bromo-4-fluoro-5-chloroaniline;2-BROMO-5-CHLORO-4-FLUOROANILINE;3-broMo-5-chloro-2-fluorobenzenaMine;2-bromo-5-chloro-4-fluorobenzenamine;Benzenamine, 2-bromo-5-chloro-4-fluoro-;1-Amino-2-bromo-5-chloro-4-fluorobenzene
- CBNumber
- CB61476172
- Molecular Formula
- C6H4BrClFN
- Formula Weight
- 224.46
- MOL File
- 85462-59-5.mol
2-Bromo-5-chloro-4-fluoroaniline Property
- Melting point:
- 75-79°
- Boiling point:
- 272.5±35.0 °C(Predicted)
- Density
- 1.809±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 1.54±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2921420090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B415775
- Product name
- 2-Bromo-5-chloro-4-fluoroaniline
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B415775
- Product name
- 2-Bromo-5-chloro-4-fluoroaniline
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- Y4290
- Product name
- 2-Bromo-5-chloro-4-fluorobenzenamine
- Packaging
- 2g
- Price
- $137
- Updated
- 2021/12/16
- Product number
- 3630-F-02
- Product name
- 2-Bromo-5-chloro-4-fluoroaniline
- Packaging
- 5G
- Price
- $144
- Updated
- 2021/12/16
- Product number
- FB12559
- Product name
- 2-Bromo-5-chloro-4-fluoroaniline
- Packaging
- 10g
- Price
- $180
- Updated
- 2021/12/16
2-Bromo-5-chloro-4-fluoroaniline Chemical Properties,Usage,Production
Synthesis
367-21-5
85462-59-5
General procedure for the synthesis of 2-bromo-4-fluoro-5-chloroaniline from 3-chloro-4-fluoroaniline: to a solution of 3-chloro-4-fluoroaniline (5 g, 34.3 mmol) in dichloromethane (60 mL) under ice-bath cooling conditions was added pyridine (4.2 ml, 51.5 mmol), and bromine (1.8 ml, 34.3 mmol) was added slowly and dropwise to a dichloromethane ( 40mL) solution. The reaction mixture was stirred continuously for 1 hour under an ice bath. Upon completion of the reaction, the reaction was quenched by adding aqueous sodium thiosulfate to the mixture and extracted with ethyl acetate. The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane) to afford the target product 2-bromo-4-fluoro-5-chloroaniline (6.4 g, yield: 83%) as an orange solid. m/z = 223 [M + H]+ by LC-MS.
References
[1] Patent: EP3112369, 2017, A1. Location in patent: Paragraph 0296; 0297
[2] Patent: EP2952510, 2015, A1. Location in patent: Paragraph 0196
[3] Tetrahedron Letters, 2002, vol. 43, # 42, p. 7581 - 7583
[4] European Journal of Medicinal Chemistry, 2012, vol. 50, p. 179 - 195
2-Bromo-5-chloro-4-fluoroaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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