4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone

Uses

Product Name: 4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone
CAS No.: 56632-83-8
Chemical Name: 4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone
Synonyms: 2'-Deoxy-2'-fluoro-beta-D-arabinocytidine;2'-FANA-cytidine;Eravacycline Impurity 10;2'-Fluoro-2'-deoxy-arabino-Cytidine;2’-Deoxy-2’-fluoro-β-D-arabinocytidine;2’-Deoxy-2’-fluoro-b-D-arabinocytidine;2’-Deoxy-2’-fluoro-?-D-arabino cytidine;2’-Deoxy-2’-fluoro-beta-D-arabinocytidine;2'-Fluoro-2'-deoxy-arabinofuranosyl-cytidine;2’-Deoxy-2’-fluoro-beta-D-arabinocytidine, FAC
CBNumber: CB61480012
Molecular Formula: C9H12FN3O4
Formula Weight: 245.21
MOL File: 56632-83-8.mol

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4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone Property

Melting point:: 136-138 °C
Boiling point:: 500.1±60.0 °C(Predicted)
Density: 1.82±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO: Soluble
Methanol: Soluble
form: Solid
pka: 12.84±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D239965
Product name: 1-(2''-Deoxy-2''-fluoro-b-D-arabinofuranosyl)cytosineHydrochloride
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: ND08343
Product name: 1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)cytosine HCl
Packaging: 50mg
Price: $85
Updated: 2021/12/16

Biosynth Carbosynth

Product number: ND08343
Product name: 1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)cytosine HCl
Packaging: 100mg
Price: $135
Updated: 2021/12/16

Biosynth Carbosynth

Product number: ND08343
Product name: 1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)cytosine HCl
Packaging: 250mg
Price: $225
Updated: 2021/12/16

Biosynth Carbosynth

Product number: ND08343
Product name: 1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)cytosine HCl
Packaging: 500mg
Price: $350
Updated: 2021/12/16

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4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone Chemical Properties,Usage,Production

Uses

1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)cytosine HCl is a useful research chemical.

Uses

2’-Deoxy-2’-fluoro-b-D-arabinocytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Synthesis

128495-99-8

56632-83-8

General procedure for the synthesis of 4-amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone: 4-amino-1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone (3.60 mmol) was dissolved in saturated ammonia methanol solution (30 mL ) in saturated ammonia methanol solution (30 mL) and the reaction was stirred at room temperature for 15 hours. After completion of the reaction, the solvent was removed by concentration under reduced pressure to obtain the crude product. 5.64 (dd, J = 19.44 Hz, 1H, H-3'), 5.26 (d, J = 48.2 Hz, 1H, H-2'), 4.50 (m, 1H, H-4'), 3.70-3.77 (m, 2H, H-5').

References

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
[2] SHINJI MIURA . Antitumor activity of a novel orally effective nucleoside, 1-(2-deoxy-2-fluoro-4-thio-β-d-arabinofuranosyl)cytosine[J]. Cancer letters, 1998, 129 1: Pages 103-110. DOI: 10.1016/s0304-3835(98)00089-5
[3] J. A. MARTIN. ChemInform Abstract: Synthesis and Antiviral Activity of Monofluoro and Difluoro Analogues of Pyrimidine Deoxyribonucleosides Against Human Immunodeficiency Virus (HIV-1).[J]. ChemInform, 1991, 22 4. DOI: 10.1002/chin.199104325
[4] KYOICHI A. WATANABE. Nucleosides. 123. Synthesis of antiviral nucleosides: 5-substituted 1-(2-deoxy-2-halogeno-.beta.-D-arabinofuranosyl)cytosines and -uracils. Some structure-activity relationships[J]. Journal of Medicinal Chemistry, 1983, 26 2: 152-156. DOI: 10.1021/jm00356a007

4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone Suppliers

China 71 Germany 1 India 1 United Kingdom 1 United States 6 Global 80

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View Lastest Price from 4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Eravacycline Impurity 10
Price: US $0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 5g
Release date: 2025-03-21

Career Henan Chemical Co

Product: 4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone 56632-83-8
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 564
Release date: 2019-09-01

56632-83-8, 4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinoneRelated Search:

CHLOROPHOSPHONAZO III Glycine ALTRENOGEST Glucosamine Furazolidone Tetrahydrofuran Aminopyrine 6-Aminocaproic acid Acetaminophen Tris(hydroxymethyl)aminomethane EC 2.6.1.2 3-Aminophenol Carbofuran Fluorine AMINO ACIDS 4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone

4-amino-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

4-AMino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)pyriMidin-2(1H)-one

FN-008 2'-Fluoro-2'-deoxy-arabinofuranosyl-cytidine

1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)cytosine

2(1H)-Pyrimidinone, 4-amino-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-

4-Amino-1-(2-deoxy-2-fluoro--D-arabinofuranosyl)-2(1H)-pyrimidinone

1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)cytosine

2'-Fluoro-2'-deoxy-arabinofuranosyl-cytidine

2'-Deoxy-2'-fluoro-beta-D-arabinocytidine

4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone

1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)cytosine HCl

2’-Deoxy-2’-fluoro-beta-D-arabinocytidine, FAC

2’-Deoxy-2’-fluoro-β-D-arabinocytidine

1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)cytosine Hydrochloride

4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-p...

2'-Fluoro-2'-deoxy-arabino-Cytidine

2’-Deoxy-2’-fluoro-beta-D-arabinocytidine, FAC, anticancer,metabolite of FIAC (GL100674), impurity of Azvudine

2’-Deoxy-2’-fluoro-b-D-arabinocytidine

2’-Deoxy-2’-fluoro-?-D-arabino cytidine

2'-FANA-cytidine

2’-Deoxy-2’-fluoro-beta-D-arabinocytidine

Eravacycline Impurity 10

4-Amino-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-2(1H)-pyrimidinone

56632-83-8

Nucleosides-2'-FANA Nucleosides