Uses
ChemicalBook > CAS DataBase List > 4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone

4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone

Uses
Product Name
4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone
CAS No.
56632-83-8
Chemical Name
4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone
Synonyms
2'-Deoxy-2'-fluoro-beta-D-arabinocytidine;2'-FANA-cytidine;Eravacycline Impurity 10;2'-Fluoro-2'-deoxy-arabino-Cytidine;2’-Deoxy-2’-fluoro-β-D-arabinocytidine;2’-Deoxy-2’-fluoro-b-D-arabinocytidine;2’-Deoxy-2’-fluoro-?-D-arabino cytidine;2’-Deoxy-2’-fluoro-beta-D-arabinocytidine;2'-Fluoro-2'-deoxy-arabinofuranosyl-cytidine;2’-Deoxy-2’-fluoro-beta-D-arabinocytidine, FAC
CBNumber
CB61480012
Molecular Formula
C9H12FN3O4
Formula Weight
245.21
MOL File
56632-83-8.mol
More
Less

4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone Property

Melting point:
136-138 °C
Boiling point:
500.1±60.0 °C(Predicted)
Density 
1.82±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO: Soluble
Methanol: Soluble
form 
Solid
pka
12.84±0.70(Predicted)
color 
White to off-white
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
D239965
Product name
1-(2''-Deoxy-2''-fluoro-b-D-arabinofuranosyl)cytosineHydrochloride
Packaging
10mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
ND08343
Product name
1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)cytosine HCl
Packaging
50mg
Price
$85
Updated
2021/12/16
Biosynth Carbosynth
Product number
ND08343
Product name
1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)cytosine HCl
Packaging
100mg
Price
$135
Updated
2021/12/16
Biosynth Carbosynth
Product number
ND08343
Product name
1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)cytosine HCl
Packaging
250mg
Price
$225
Updated
2021/12/16
Biosynth Carbosynth
Product number
ND08343
Product name
1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)cytosine HCl
Packaging
500mg
Price
$350
Updated
2021/12/16
More
Less

4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone Chemical Properties,Usage,Production

Uses

1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)cytosine HCl is a useful research chemical.

Uses

2’-Deoxy-2’-fluoro-b-D-arabinocytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Synthesis

128495-99-8

56632-83-8

General procedure for the synthesis of 4-amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone: 4-amino-1-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone (3.60 mmol) was dissolved in saturated ammonia methanol solution (30 mL ) in saturated ammonia methanol solution (30 mL) and the reaction was stirred at room temperature for 15 hours. After completion of the reaction, the solvent was removed by concentration under reduced pressure to obtain the crude product. 5.64 (dd, J = 19.44 Hz, 1H, H-3'), 5.26 (d, J = 48.2 Hz, 1H, H-2'), 4.50 (m, 1H, H-4'), 3.70-3.77 (m, 2H, H-5').

References

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
[2] SHINJI MIURA . Antitumor activity of a novel orally effective nucleoside, 1-(2-deoxy-2-fluoro-4-thio-β-d-arabinofuranosyl)cytosine[J]. Cancer letters, 1998, 129 1: Pages 103-110. DOI: 10.1016/s0304-3835(98)00089-5
[3] J. A. MARTIN. ChemInform Abstract: Synthesis and Antiviral Activity of Monofluoro and Difluoro Analogues of Pyrimidine Deoxyribonucleosides Against Human Immunodeficiency Virus (HIV-1).[J]. ChemInform, 1991, 22 4. DOI: 10.1002/chin.199104325
[4] KYOICHI A. WATANABE. Nucleosides. 123. Synthesis of antiviral nucleosides: 5-substituted 1-(2-deoxy-2-halogeno-.beta.-D-arabinofuranosyl)cytosines and -uracils. Some structure-activity relationships[J]. Journal of Medicinal Chemistry, 1983, 26 2: 152-156. DOI: 10.1021/jm00356a007

4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone Suppliers

China 70 Germany 1 India 1 United Kingdom 1 United States 6 Global 79
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
More
Less

View Lastest Price from 4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Eravacycline Impurity 10
Price
US $0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
5g
Release date
2025-03-21
Career Henan Chemical Co
Product
4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone 56632-83-8
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
JD 564
Release date
2019-09-01

56632-83-8, 4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinoneRelated Search:

CHLOROPHOSPHONAZO III Glycine ALTRENOGEST Glucosamine Furazolidone Tetrahydrofuran Aminopyrine 6-Aminocaproic acid Acetaminophen Tris(hydroxymethyl)aminomethane EC 2.6.1.2 3-Aminophenol Carbofuran Fluorine AMINO ACIDS 4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone

  • 4-amino-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
  • 4-AMino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)pyriMidin-2(1H)-one
  • FN-008 2'-Fluoro-2'-deoxy-arabinofuranosyl-cytidine
  • 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)cytosine
  • 2(1H)-Pyrimidinone, 4-amino-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-
  • 4-Amino-1-(2-deoxy-2-fluoro--D-arabinofuranosyl)-2(1H)-pyrimidinone
  • 1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)cytosine
  • 2'-Fluoro-2'-deoxy-arabinofuranosyl-cytidine
  • 2'-Deoxy-2'-fluoro-beta-D-arabinocytidine
  • 4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone
  • 1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)cytosine HCl
  • 2’-Deoxy-2’-fluoro-beta-D-arabinocytidine, FAC
  • 2’-Deoxy-2’-fluoro-β-D-arabinocytidine
  • 1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)cytosine Hydrochloride
  • 4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-p...
  • 2'-Fluoro-2'-deoxy-arabino-Cytidine
  • 2’-Deoxy-2’-fluoro-beta-D-arabinocytidine, FAC, anticancer,metabolite of FIAC (GL100674), impurity of Azvudine
  • 2’-Deoxy-2’-fluoro-b-D-arabinocytidine
  • 2’-Deoxy-2’-fluoro-?-D-arabino cytidine
  • 2'-FANA-cytidine
  • 2’-Deoxy-2’-fluoro-beta-D-arabinocytidine
  • Eravacycline Impurity 10
  • 4-Amino-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-2(1H)-pyrimidinone
  • 56632-83-8
  • Nucleosides-2'-FANA Nucleosides