4-Amino-2,6-dichloropyridine
- Product Name
- 4-Amino-2,6-dichloropyridine
- CAS No.
- 2587-02-2
- Chemical Name
- 4-Amino-2,6-dichloropyridine
- Synonyms
- 2,6-DICHLOROPYRIDIN-4-AMINE;2,6-DICHLORO-PYRIDIN-4-YLAMINE;2,6-dichloro-4-pyridinamine;2,6-DICHLORO-4-AMINOPYRIDINE;0/2/87;NSC 136573;AURORA KA-3022;4-Amino-2,6-dichL;6-Dichloro-4-pyridinamine;4-Ami-2,6-dichloropyridine
- CBNumber
- CB6151104
- Molecular Formula
- C5H4Cl2N2
- Formula Weight
- 163
- MOL File
- 2587-02-2.mol
4-Amino-2,6-dichloropyridine Property
- Melting point:
- 169-173 °C (lit.)
- Boiling point:
- 336.7±37.0 °C(Predicted)
- Density
- 1.497±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Powder
- pka
- 0.49±0.50(Predicted)
- color
- White to buff
- BRN
- 114351
- InChI
- InChI=1S/C5H4Cl2N2/c6-4-1-3(8)2-5(7)9-4/h1-2H,(H2,8,9)
- InChIKey
- WAEZOSSWRXDWAX-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(Cl)=CC(N)=C1
- CAS DataBase Reference
- 2587-02-2(CAS DataBase Reference)
- NIST Chemistry Reference
- Pyridine, 4-amino-2,6-dichloro-(2587-02-2)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 565342
- Product name
- 4-Amino-2,6-dichloropyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $65.4
- Updated
- 2025/07/31
- Product number
- A2369
- Product name
- 4-Amino-2,6-dichloropyridine
- Purity
- >97.0%(GC)(N)
- Packaging
- 1g
- Price
- $40
- Updated
- 2025/07/31
- Product number
- A2369
- Product name
- 4-Amino-2,6-dichloropyridine
- Purity
- >97.0%(GC)(N)
- Packaging
- 5g
- Price
- $122
- Updated
- 2025/07/31
- Product number
- A604710
- Product name
- 4-Amino-2,6-dichloropyridine
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- A604710
- Product name
- 4-Amino-2,6-dichloropyridine
- Packaging
- 10g
- Price
- $95
- Updated
- 2021/12/16
4-Amino-2,6-dichloropyridine Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
4-Amino-2,6-dichloropyridine is a compound useful in organic synthesis used in the synthesis of Rho kinase inhibitors.
Synthesis
25194-01-8
2587-02-2
The general procedure for the synthesis of 4-amino-2,6-dichloropyridine from 2,6-dichloro-4-nitropyridine was as follows: to a solution of 2,6-dichloro-4-nitropyridine (14.82 g, 76.79 mmol) in ethanol (350 mL) was added sequentially iron powder (19.91 g, 356.58 mmol), water (65.8 mL, 3.6 mol), and concentrated hydrochloric acid (14.1 mL, 464.1 mmol). The reaction was carried out at 95 °C with stirring for 16 hours. After completion of the reaction, the reaction solution was cooled to room temperature and the pH was adjusted to neutral. After filtration, the filtrate was concentrated and extracted with ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate, and the solvent was removed by rotary evaporation to afford 11.9 g of the title product 4-amino-2,6-dichloropyridine in 95.1% yield.
References
[1] Patent: US2012/289497, 2012, A1. Location in patent: Page/Page column 51-52
[2] Patent: EP2524917, 2012, A1. Location in patent: Page/Page column 58-59
[3] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 3, p. 1511 - 1530
[4] Nucleosides, Nucleotides and Nucleic Acids, 2003, vol. 22, # 12, p. 2133 - 2144
[5] ChemCatChem, 2016, vol. 8, # 8, p. 1485 - 1489
4-Amino-2,6-dichloropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Amino-2,6-dichloropyridine manufacturers
- Product
- 4-Amino-2,6-dichloropyridine 2587-02-2
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-19
- Product
- 4-Amino-2,6-dichloropyridine 2587-02-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-01
- Product
- 2,6-Dichloropyridin-4-amine 2587-02-2
- Price
- US $2100.00/Kg
- Min. Order
- 1Kg
- Purity
- 98
- Supply Ability
- 500 Kg
- Release date
- 2024-04-11