METHYL4-BROMOFURAN-2-CARBOXYLATE
- Product Name
- METHYL4-BROMOFURAN-2-CARBOXYLATE
- CAS No.
- 58235-80-6
- Chemical Name
- METHYL4-BROMOFURAN-2-CARBOXYLATE
- Synonyms
- METHYL4-BROMOFURAN-2-CARBOXYLATE;4-broMo-3-Methylfuran-2-carboxylate;4-Bromofuran-2-carboxylic acid methyl;4-Bromofuran-2-carboxylic acid methyl ester;2-Furancarboxylic acid, 4-bromo-, methyl ester
- CBNumber
- CB61511123
- Molecular Formula
- C6H5BrO3
- Formula Weight
- 205.01
- MOL File
- 58235-80-6.mol
METHYL4-BROMOFURAN-2-CARBOXYLATE Property
- Melting point:
- 42-44 °C
- Boiling point:
- 228℃
- Density
- 1.623
- Flash point:
- 92℃
- storage temp.
- 2-8°C
- Appearance
- White to yellow Solid
- InChI
- InChI=1S/C6H5BrO3/c1-9-6(8)5-2-4(7)3-10-5/h2-3H,1H3
- InChIKey
- RKEXKLRKXLRNMV-UHFFFAOYSA-N
- SMILES
- O1C=C(Br)C=C1C(OC)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 455479
- Product name
- Methyl 4-Bromofuran-2-carboxylate
- Packaging
- 100mg
- Price
- $355
- Updated
- 2021/12/16
- Product number
- M294060
- Product name
- Methyl4-Bromofuran-2-carboxylate
- Packaging
- 2.5g
- Price
- $1095
- Updated
- 2021/12/16
- Product number
- HCH0142197
- Product name
- METHYL-4-BROMOFURAN-2-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1346.73
- Updated
- 2021/12/16
- Product number
- 074734
- Product name
- Methyl 4-bromofuran-2-carboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $1750
- Updated
- 2021/12/16
- Product number
- CS-M2917
- Product name
- 4-Bromofuran-2-carboxylicacidmethylester
- Purity
- >98.0%
- Packaging
- 25g
- Price
- $617
- Updated
- 2021/12/16
METHYL4-BROMOFURAN-2-CARBOXYLATE Chemical Properties,Usage,Production
Uses
Methyl 4-Bromofuran-2-carboxylate is used to prepare pyrimidinamines and pyridinamines as adenosine receptor modulators for treatment of CNS disorders.
Synthesis
54113-41-6
58235-80-6
General procedure for the synthesis of methyl 4-bromofuran-2-carboxylate from methyl 4,5-dibromofuran-2-carboxylate: isopropylmagnesium chloride (2M solution of THF, 38 mL) was added slowly and dropwise to a solution of methyl 4,5-dibromofuran-2-carboxylate (14.2 g, 50 mmol) in anhydrous THF (100 mL) at -40 °C and under nitrogen protection. The reaction mixture was stirred continuously at the same temperature for 1 h. The reaction was subsequently quenched by the addition of water (50 mL). The precipitate was collected by filtration and the filtrate was extracted by partitioning with ethyl acetate and water. The organic phase was washed twice with saturated saline, dried over anhydrous sodium sulfate and purified by silica gel column chromatography to afford the target product, methyl 4-bromofuran-2-carboxylate (11a), as a yellow solid (9 g, 89% yield).1H NMR (400 MHz, DMSO-d6) δ 8.22 (s, 1H), 7.51 (s, 1H), 3.82 (s, 3H).
References
[1] European Journal of Medicinal Chemistry, 2016, vol. 117, p. 47 - 58
[2] Journal of Agricultural and Food Chemistry, 2017, vol. 65, # 26, p. 5397 - 5403
[3] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 6, p. 2019 - 2024
[4] Patent: CN105503832, 2016, A. Location in patent: Paragraph 0065; 0066; 0069; 0070
[5] Patent: WO2008/98104, 2008, A1. Location in patent: Page/Page column 217
METHYL4-BROMOFURAN-2-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
METHYL4-BROMOFURAN-2-CARBOXYLATE Suppliers
- Tel
- --
- Fax
- --
- sales@rarechem.de
- Country
- Germany
- ProdList
- 6297
- Advantage
- 38
View Lastest Price from METHYL4-BROMOFURAN-2-CARBOXYLATE manufacturers
- Product
- Methyl 4-bromofuran-2-carboxylate 58235-80-6
- Price
- US $1.60-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
- Product
- methyl 4-bromofuran-2-carboxylate 58235-80-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 50kgs/month
- Release date
- 2021-11-20
- Product
- METHYL4-BROMOFURAN-2-CARBOXYLATE 58235-80-6
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-18