Description References
ChemicalBook > CAS DataBase List > 5-Chloro-1-methyl-4-nitroimidazole

5-Chloro-1-methyl-4-nitroimidazole

Description References
Product Name
5-Chloro-1-methyl-4-nitroimidazole
CAS No.
4897-25-0
Chemical Name
5-Chloro-1-methyl-4-nitroimidazole
Synonyms
5-CHLORO-1-METHYL-4-NITRO-1H-IMIDAZOLE;CMNI;pcmni;NSC-7852;S-50154-9;A(S50154-9);AZATHIOPRINUM;TIMTEC-BB SBB003949;Azathioprine Impurity 9;Azathioprine EP Impurity C
CBNumber
CB6151649
Molecular Formula
C4H4ClN3O2
Formula Weight
161.55
MOL File
4897-25-0.mol
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5-Chloro-1-methyl-4-nitroimidazole Property

Melting point:
148-150 °C (lit.)
Boiling point:
362.3±22.0 °C(Predicted)
Density 
1.9518 (rough estimate)
refractive index 
1.5500 (estimate)
storage temp. 
Inert atmosphere,2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
-1.37±0.61(Predicted)
form 
Powder
color 
White
InChIKey
OSJUNMSWBBOTQU-UHFFFAOYSA-N
CAS DataBase Reference
4897-25-0(CAS DataBase Reference)
NIST Chemistry Reference
1H-imidazole, 5-chloro-1-methyl-4-nitro-(4897-25-0)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
RTECS 
NI4397100
HazardClass 
IRRITANT
HS Code 
29332900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
367532
Product name
5-Chloro-1-methyl-4-nitroimidazole
Purity
98%
Packaging
5g
Price
$138
Updated
2024/03/01
TCI Chemical
Product number
C1646
Product name
5-Chloro-1-methyl-4-nitroimidazole
Purity
>98.0%(N)
Packaging
5g
Price
$84
Updated
2024/03/01
Alfa Aesar
Product number
H61824
Product name
5-Chloro-1-methyl-4-nitroimidazole, 95%
Packaging
1g
Price
$33.9
Updated
2023/06/20
Alfa Aesar
Product number
H61824
Product name
5-Chloro-1-methyl-4-nitroimidazole, 95%
Packaging
5g
Price
$115
Updated
2023/06/20
TRC
Product number
C369270
Product name
5-Chloro-1-methyl-4-nitroimidazole
Packaging
5g
Price
$120
Updated
2021/12/16
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5-Chloro-1-methyl-4-nitroimidazole Chemical Properties,Usage,Production

Description

5-Chloro-1-methyl-4-nitroimidazole is an imidazole derivative. It is useful in the rapid mix experiments to investigate the mechanism of anomalous radiosensitization of mammalian cells. It can also be used in the synthesis of 5-aryl-1-methyl-4-nitroimidazoles, via Suzuki coupling with arylboronic acids, catalyzed by dichlorobis-(triphenylphosphine) palladium (II), K2CO3 and tetrabutylammonium bromide. 

References

http://www.sigmaaldrich.com/catalog/product/aldrich/367532?lang=en&region=US
Watts, M. E., et al. "Rapid-mix studies on the anomalous radiosensitization of mammalian cells by 5-chloro-1-methyl-4-nitromidazole." Int J Radiat Biol Relat Stud Phys Chem Med 38.6(1980):673-675.
Saadeh, H. A, I. M. Mosleh, and M. M. Elabadelah. "New synthesis and antiparasitic activity of model 5-aryl-1-methyl-4-nitroimidazoles. "Molecules 14.8(2009):2758-67.

Description

5-Chloro-1-methyl-4-nitroimidazole is an intermediate in azathioprine synthesis, also present in the end product. It induced contact dermatitis in a man working on azathioprine synthesis. Cross reactivity is possible with imidazoles tioconazole, and econazole.

Chemical Properties

White Solid

Uses

5-Chloro-1-methyl-4-nitroimidazole (CMNI) is suitable for use in the rapid mix experiments to investigate the mechanism of anomalous radiosensitization of mammalian cells by CMNI. It may be used in the synthesis of 5-aryl-1-methyl-4-nitroimidazoles, via Suzuki coupling with arylboronic acids, catalyzed by dichlorobis-(triphenylphosphine)palladium(II), K2CO3 and tetrabutylammonium bromide.

General Description

5-Chloro-1-methyl-4-nitroimidazole is an 4-nitroimidazole derivative.

Contact allergens

This intermediate in azathioprine synthesis is also present in the end product. It induced contact dermatitis in a man working on azathioprine synthesis. Cross-reactivity is possible with imidazoles tioconazole and econazole.

5-Chloro-1-methyl-4-nitroimidazole Preparation Products And Raw materials

Raw materials

Glass-lined reaction pot Phosphorus oxychloride Phosphorus pentachloride N,N'-Dimethyloxamide 5-Chloro-1-methylimidazole Potassium nitrate

Preparation Products

Azathioprine
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5-Chloro-1-methyl-4-nitroimidazole Suppliers

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View Lastest Price from 5-Chloro-1-methyl-4-nitroimidazole manufacturers

airuikechemical co., ltd.
Product
5-Chloro-1-methyl-4-nitroimidazole 4897-25-0
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
200tons
Release date
2024-04-08
Shaanxi Dideu Medichem Co. Ltd
Product
5-Chloro-1-methyl-4-nitroimidazole 4897-25-0
Price
US $1.00-2.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
20000KG
Release date
2024-08-08
Henan Aochuang Chemical Co.,Ltd.
Product
5-Chloro-1-methyl-4-nitroimidazole 4897-25-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-29

4897-25-0, 5-Chloro-1-methyl-4-nitroimidazoleRelated Search:

Imidazole 4-Nitroimidazole Methylparaben 1-Methylimidazole Methyl acrylate Bensulfuron methyl Thiophanate-methyl Kresoxim-methyl Methyl Difluorochloromethane nitrotoluene Parathion-methyl Methyl bromide Imidazole, 1-methyl-4-nitro- 5-Chloro-1-methyl-4-nitroimidazole 5-CHLORO-4-NITRO-1-ISOBUTYL-2-ISOPROPYL-1H-IMIDAZOLE 5-CHLORO-2-ETHYL-4-NITRO-1-PROPYL-1H-IMIDAZOLE

  • 5-chloro-1-methyl-4-nitroimidazole Solution, 100ppm
  • 5-Chloro-1-methyl-4-nitroimidazole≥ 99% (HPLC)
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  • Azathioprine Impurity Ⅰ: 5-Chloro-1-methyl-4-nitroimidazole
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  • A(S50154-9)
  • Imidazole, 5-chloro-1-methyl-4-nitro-
  • pcmni
  • TIMTEC-BB SBB003949
  • 1-METHYL-5-CHLORO-4-NITRO IMIDAZOLE
  • 1-METHYL-4-NITRO-5-CHLORO IMIDAZOLE
  • AZATHIOPRINUM
  • 5-CHLORO-1-METHYL-4-NITRO-1H-IMIDAZOLE
  • 5-CHLORO-1-METHYL-4-NITROIMIDAZOLE
  • 5-Chloro-1-Methyl-4-NitroImidazole(ForAzathiopurine)
  • 5-CHLORO-1-METHYL-4-NITROIMIDAZOLE (AZATHIOPRINUM)
  • 1-Methyl-4-Nitro-5-Chloroimida
  • 1H-Imidazole, 5-chloro-1-methyl-4-nitro-
  • S-50154-9
  • 1-Methyl-5-chloro-4-nitro-1H-imidazole
  • CMNI
  • NSC-7852
  • 5-Chloro-1-methyl-4-nitroimidazole,98%
  • Azathioprine Impurity 3（Azathioprine EP Impurity C）
  • 5-Chloro-1-methyl-4-nitroimidazole &gt
  • Azathioprine Impurity 9
  • Azathioprine BP Impurity C
  • 5-Chloro-1-methyl-4-nitroimidazole Solution in Methanol, 100μg/mL
  • Azathioprine Impurity Ⅰ: 5-Chloro-1-methyl-4-nitroimidazole
  • 5-Chloro-1-methyl-4-nitroimidazole (Azathioprine Impurity)
  • 4897-25-0
  • C4H4ClN3O2
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Imidazoles
  • Heterocycles
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Imidazoles
  • ImidazolesBuilding Blocks
  • Building Blocks
  • Chemical Synthesis
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Heterocyclic Compounds
  • Imidaxoles