Methyl 2-amino-3-nitrobenzoate

Product Name: Methyl 2-amino-3-nitrobenzoate
CAS No.: 57113-91-4
Chemical Name: Methyl 2-amino-3-nitrobenzoate
Synonyms: Methyl 3-nitroanthranilate;2-AMINO-3-NITROBENZOIC ACID METHYL ESTER;Azilsartan SM1-E;RARECHEM AH CK 0023;Amylocaine Impurity 1;Methyl3-Nitroanthranilate>METHYL 2-AMINO-3-NITROBENZOATE;2-Amino-3-nitro-benzoic acid meth;Methyl 2-amino-3-nitrobenzoate 95%;3-Nitro-anthranilic Acid Methyl Ester
CBNumber: CB6157641
Molecular Formula: C8H8N2O4
Formula Weight: 196.16
MOL File: 57113-91-4.mol

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Methyl 2-amino-3-nitrobenzoate Property

Melting point:: 97-98°C
Boiling point:: 340.1±22.0 °C(Predicted)
Density: 1.386±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO, Ethyl Acetate
pka: -2.80±0.25(Predicted)
form: Solid
color: Yellow
InChI: InChI=1S/C8H8N2O4/c1-14-8(11)5-3-2-4-6(7(5)9)10(12)13/h2-4H,9H2,1H3
InChIKey: HDCLJQZLTMJECA-UHFFFAOYSA-N
SMILES: C(OC)(=O)C1=CC=CC([N+]([O-])=O)=C1N
CAS DataBase Reference: 57113-91-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36/37/39
Hazard Note: Irritant
HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ANV00032
Product name: 2-Amino-3-nitrobenzoic acid methylester
Purity: Aldrich<SUP>CPR</SUP>
Packaging: 1 g
Price: $185
Updated: 2025/07/31

TCI Chemical

Product number: M2158
Product name: Methyl 3-Nitroanthranilate
Purity: >98.0%(GC)
Packaging: 1g
Price: $245
Updated: 2025/07/31

TRC

Product number: M286920
Product name: Methyl2-Amino-3-nitrobenzoate
Packaging: 2.5g
Price: $875
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0020249
Product name: 2-AMINO-3-NITROBENZOIC ACID METHYL ESTER
Purity: 95.00%
Packaging: 1G
Price: $808.89
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0020249
Product name: 2-AMINO-3-NITROBENZOIC ACID METHYL ESTER
Purity: 95.00%
Packaging: 2.5G
Price: $1147.43
Updated: 2021/12/16

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Methyl 2-amino-3-nitrobenzoate Chemical Properties,Usage,Production

Chemical Properties

Yellow Solid

Uses

Methyl 2-amino-3-nitrobenzoate is used as an intermediate in the preparation of Candesartan.

Synthesis

67-56-1

606-18-8

57113-91-4

2-Amino-3-nitrobenzoic acid (1.00 g, 5.49 mmol) was dissolved in methanol (40 mL) followed by the addition of concentrated sulfuric acid (0.50 mL). The reaction mixture was heated to reflux for 48 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted with saturated aqueous sodium bicarbonate to about 9. The mixture was concentrated under reduced pressure to about 10 mL, water (20 mL) was added, and the mixture was extracted with ethyl acetate (10 mL x 3 times). The organic layers were combined and dried with anhydrous magnesium sulfate. The organic layers were concentrated under reduced pressure and the resulting crystals were dried to give methyl 2-amino-3-nitrobenzoate. The product was structurally confirmed by nuclear magnetic resonance hydrogen spectroscopy (1H-NMR). Yield: 661.4 mg (61%). 1H-NMR (270 MHz, CDCl3): δ 8.50 (br, s), 8.37 (1H, dd, J = 8.6, 1.4 Hz), 8.23 (1H, dd, J = 7.6, 1.4 Hz), 6.65 (1H, dd, J = 8.6, 7.6 Hz), 3.92 (3H, s ) ppm.

References

[1] Patent: EP1452528, 2004, A1. Location in patent: Page 21-22
[2] Patent: EP1502916, 2005, A1. Location in patent: Page 435
[3] Journal of Medicinal Chemistry, 2000, vol. 43, # 22, p. 4084 - 4097
[4] Journal of Organic Chemistry, 2013, vol. 78, # 17, p. 8217 - 8231
[5] Patent: WO2007/100295, 2007, A1. Location in patent: Page/Page column 253

Methyl 2-amino-3-nitrobenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 2-amino-3-nitrobenzoate Suppliers

Americas 1 Canada 3 China 232 Europe 1 Germany 5 India 20 Japan 1 Switzerland 1 United Kingdom 13 United States 19 Global 296

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Fluorochem Ltd.

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View Lastest Price from Methyl 2-amino-3-nitrobenzoate manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: Methyl 2-amino-3-nitrobenzoate 57113-91-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-08-19

Henan Aochuang Chemical Co.,Ltd.

Product: Methyl 2-amino-3-nitrobenzoate 57113-91-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-17

Career Henan Chemical Co

Product: Methyl 2-amino-3-nitrobenzoate 57113-91-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2018-08-06

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57113-91-4

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57113-91-4