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DEXBROMPHENIRAMINE

Product Name
DEXBROMPHENIRAMINE
CAS No.
132-21-8
Chemical Name
DEXBROMPHENIRAMINE
Synonyms
Disomer;D-Brompheniramine;DEXBROMPHENIRAMINE;d-Parabromdylamine;(S)-Brompheniramine;DEXBROMPHENIRAMINE BASE;DEXBROMPHENIRAMINE USP/EP/BP;(S)-γ-(4-Bromophenyl)-N,N-dimethyl-2-pyridinepropan-1-amine;[(3S)-3-(4-bromophenyl)-3-(2-pyridyl)propyl]-dimethyl-amine;2-Pyridinepropanamine, γ-(4-bromophenyl)-N,N-dimethyl-, (γS)-
CBNumber
CB6164683
Molecular Formula
C16H19BrN2
Formula Weight
319.24
MOL File
132-21-8.mol
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DEXBROMPHENIRAMINE Property

alpha 
D25 +42.7° (c = 1 in DMF)
pka
pKa 9.3 (Uncertain)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0002276
Product name
DEXBROMPHENIRAMINE
Purity
95.00%
Packaging
5MG
Price
$345.4
Updated
2021/12/16
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DEXBROMPHENIRAMINE Chemical Properties,Usage,Production

Originator

Disomer,White,US,1959

Uses

Antihistaminic.

Definition

ChEBI: The (pharmacologically active) (S)-(+)-enantiomer of brompheniramine. A histamine H1 receptor antagonist, it is used (commonly as its maleate salt) for the symptomatic relief of allergic conditions, including rhinitis nd conjunctivitis.

Manufacturing Process

The following is taken from US Patent 3,061,517. Sixteen grams of racemic 3- (2-pyridyl)-3-p-bromophenyl-N,N,-dimethylpropylamine and 9.7 grams of dphenylsuccinic acid are dissolved in 150 ml of absolute alcohol and kept at room temperature until crystallization is effected. The crystals are filtered,washed with absolute ethyl alcohol, and recrystallized from the same solvent using 5 ml there of per gram of solid. Three subsequent crystallizations from 80% alcohol give d-3-(2-pyridyl)-3-p-bromophenyl-N,N-dimethylpropylamined-phenylsuccinate; MP 152-154°C; [α]D25 91 (concentration, 1% in dimethylformamide).
The free base, d-3-(2-pyridyl)-3-p-bromophenyl-N,N-dimethylpropylamine, is obtained from this salt with diethyl ether and aqueous potassium carbonate; [α]D25 +42.7 (concentration, 1% in dimethylformamide). The free base is then reacted with maleic acid.

brand name

Disomer (Schering).

Therapeutic Function

Antihistaminic

DEXBROMPHENIRAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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DEXBROMPHENIRAMINE Suppliers

BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
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9923
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Waterstone Technology, LLC
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sales@waterstonetech.com
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United States
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6786
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2A PharmaChem USA
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sales@2apharmachem.com
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United States
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3B Scientific Corporation
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sales@3bsc.com
Country
United States
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6718
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HONEST JOY HOLDINGS LIMITED
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sales@honestjoy.cn
Country
United States
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6675
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BOSCHE SCIENTIFIC, LLC
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Sales@BoscheSci.com
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American Custom Chemicals Corporation
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sales@acccorporation.com
Country
United States
ProdList
6820
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132-21-8, DEXBROMPHENIRAMINERelated Search:


  • (S)-Brompheniramine
  • (S)-γ-(4-Bromophenyl)-N,N-dimethyl-2-pyridinepropan-1-amine
  • Disomer
  • d-Parabromdylamine
  • (3S)-3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine
  • (3S)-3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
  • [(3S)-3-(4-bromophenyl)-3-(2-pyridyl)propyl]-dimethyl-amine
  • DEXBROMPHENIRAMINE
  • DEXBROMPHENIRAMINE BASE
  • D-Brompheniramine
  • 2-Pyridinepropanamine, γ-(4-bromophenyl)-N,N-dimethyl-, (γS)-
  • DEXBROMPHENIRAMINE USP/EP/BP
  • 132-21-8
  • 131-21-8