ChemicalBook > CAS DataBase List > (R)-3-(Boc-Amino)piperidine

(R)-3-(Boc-Amino)piperidine

Solubility in organics Uses storage

Product Name: (R)-3-(Boc-Amino)piperidine
CAS No.: 309956-78-3
Chemical Name: (R)-3-(Boc-Amino)piperidine
Synonyms: Linagliptin interMediate;(R)-3-BOC-AMINOPIPERIDINE;(R)-3-(TERT-BUTOXYCARBONYLAMINO)PIPERIDINE;R-BOC;Alogliptin-1;CAS:309956-78-3;Linagliptin INT2;R-Boc-Amino-Piperidine;Linagliptin Impurity 87;alogliptin impurities14
CBNumber: CB6169981
Molecular Formula: C10H20N2O2
Formula Weight: 200.28
MOL File: 309956-78-3.mol

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(R)-3-(Boc-Amino)piperidine Property

Melting point:: 121.0 to 125.0 °C
Boiling point:: 304.8±31.0 °C(Predicted)
Density: 1.02±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in methanol and ethanol.
pka: 12.37±0.20(Predicted)
form: Solid
color: White to Off-White
optical activity: [α]22/D +3.2°, c = 0.5 in DMF
BRN: 10662518
InChI: InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12-8-5-4-6-11-7-8/h8,11H,4-7H2,1-3H3,(H,12,13)/t8-/m1/s1
InChIKey: WUOQXNWMYLFAHT-MRVPVSSYSA-N
SMILES: C(OC(C)(C)C)(=O)N[C@@H]1CCCNC1
CAS DataBase Reference: 309956-78-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,N
Risk Statements: 37/38-41-50
Safety Statements: 26-39-61-29-36
RIDADR: 3077
WGK Germany: 2
HazardClass: 9
PackingGroup: Ⅲ
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 735868
Product name: (R)-3-(Boc-amino)piperidine
Purity: 97%
Packaging: 1g
Price: $68.7
Updated: 2025/07/31

TCI Chemical

Product number: B3591
Product name: (R)-3-(tert-Butoxycarbonylamino)piperidine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $46
Updated: 2025/07/31

TCI Chemical

Product number: B3591
Product name: (R)-3-(tert-Butoxycarbonylamino)piperidine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $153
Updated: 2025/07/31

TRC

Product number: B621135
Product name: (R)-3-(Boc-amino)piperidine
Packaging: 50g
Price: $385
Updated: 2021/12/16

TRC

Product number: B621135
Product name: (R)-3-(Boc-amino)piperidine
Packaging: 1g
Price: $50
Updated: 2021/12/16

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(R)-3-(Boc-Amino)piperidine Chemical Properties,Usage,Production

Solubility in organics

Soluble in methanol and ethanol.

Uses

(R)-3-(Boc-amino)piperidine is Boc protected (R)-3-Aminopiperidine (A627920, Dihydrochloride salt) which has been used as a reactant for the preparation of dipeptidyl peptidase IV inhibitors derived from Alogliptin.

storage

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Chemical Properties

White powder

Uses

(R)-3-(Boc-amino)piperidine is used as an organic chemical synthesis intermediate.

Synthesis

485820-12-0

309956-78-3

General procedure for the synthesis of (R)-3-Boc-aminopiperidine from benzyl (R)-3-((tert-butoxycarbonyl)amino)piperidine-1-carboxylate: 46.8 g of benzyl (R)-3-((tert-butoxycarbonyl)amino)piperidine-1-carboxylate (Compound IV), 2.3 g of 10% wet palladium-carbon (50% water) and 320 mL of methanol were added to an autoclave. The reaction system was replaced with nitrogen 3 to 4 times and the reaction temperature was raised to 35 to 40 °C under hydrogen pressure of 0.3 to 0.4 MPa and maintained for 2 hours. The progress of the reaction was monitored by HPLC until complete conversion of the feedstock. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to be free of fractions. To the concentrate, 23 mL of dichloromethane and 46 mL of petroleum ether were added and the temperature was raised to 35 to 40 °C. At this temperature, 325 mL of petroleum ether was slowly added and held for 1 hour. The reaction mixture was then slowly cooled to -5~0°C and the solid product was collected by filtration. The solid was dried at 40~45°C to give 26.7 g of white solid (R)-3-Boc-aminopiperidine in 95.4% yield.

References

[1] Patent: CN105130879, 2018, B. Location in patent: Paragraph 0064; 0065; 0066; 0067; 0068; 0069; 0070
[2] Patent: WO2004/33455, 2004, A2. Location in patent: Page 27
[3] Patent: US2003/105077, 2003, A1

(R)-3-(Boc-Amino)piperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (R)-3-(Boc-Amino)piperidine manufacturers

Handan City Zechi trading Co., LTD

Product: (R)-3-(Boc-Amino)piperidine 309956-78-3
Price: US $1.00/g
Min. Order: 100g
Purity: 99
Supply Ability: 1000
Release date: 2025-08-11

Henan Aochuang Chemical Co.,Ltd.

Product: (R)-3-(Boc-Amino)piperidine 309956-78-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-29

Hebei Dangtong Import and export Co LTD

Product: (R)-3-(Boc-Amino)piperidine 309956-78-3
Price: US $480.00-460.00/kilograms
Min. Order: 1kilograms
Purity: 99%
Supply Ability: 100000tons
Release date: 2023-02-16

309956-78-3, (R)-3-(Boc-Amino)piperidineRelated Search:

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(R)-3-AMINO-N-TBOC-PIPERIDINE

tert-Butyl [(3R)-piperidin-3-yl]carbamate, (3R)-3-[(tert-Butoxycarbonyl)amino]piperidine

Linagliptin interMediate B

Alogliptin Benzoate interMediate F

(R)-3-(Boc-amino)piperidine,97%

(R)-3-(Boc-Amino)piperidine (R)-(+)-3-tert-Butoxycarbonylaminopiperidine

tert-butyl N-[(3R)-piperidin-3-yl]carbamate

(R)-3-(tert-Butoxycarbonylamino)piperidine

(R)-(+)-3-TERT-BUTOXYCARBO

(R)-3-(Tert-butyloxycarbonyl amino)piperidin

Linagliptin INT2

Alogliptin-1

(R)-3-N-BOC-AMINO-PIPERIDINE

(R)-3-BOC-AMINOPIPERIDINE

(R)-(+)-3-TERT-BUTOXYCARBONYLAMINOPIPERIDINE

(R)-3-(TERT-BUTOXYCARBONYLAMINO)PIPERIDINE

(R)-3-N-BOC-AMINOPIPERIDINE HCL

(r)-3-(boc-amio)piperidine

(R)-3-BOC-AMINOPIPERIDINE 99%

Carbamic acid, (3R)-3-piperidinyl-, 1,1-dimethylethyl ester (9CI)

(R)-3-Aminopiperidine, 3-BOC protected

(R)-tert-butylpiperidin-3-ylcarbamate

R-1-BOC-3-aminopiperdine

Carbamic acid, N-(3R)-3-piperidinyl-, 1,1-dimethylethyl ester

(3R)-3-Aminopiperidine, 3-BOC protected

(R)-tert-butyl piperidin-3-ylcarbamate hydrochloride

tert-Butyl (3R)-piperidin-3-ylcarbamate

(R)-3-(Boc-aMino)piperidi...

(R)-3-Boc-aMinopiperidineaMinopiperidine

(R)-3-tert-butyloxycarbonylaMino-piperidine

Linagliptin interMediate

(R)-3-(tert-Butoxycarbonylamino)piperidine &gt

ert-butylN-[(3R)-piperidin-3-yl]carbamate

(R)-3-(Boc-Amino)piperidine ISO 9001：2015 REACH

Linagliptin intermediates，(R)-3-(Boc-Amino)piperidine

Linagliptin Impurity 87

alogliptin impurities161

(3R)-3-[(tert-Butoxycarbonyl)amino]piperidine

alogliptin impurities14

(R)-3-Boc-aminopiperidineQ: What is (R)-3-Boc-aminopiperidine Q: What is the CAS Number of (R)-3-Boc-aminopiperidine Q: What is the storage condition of (R)-3-Boc-aminopiperidine

R-BOC

tert-butyl N-[(3R)-3-piperidyl]carbamate

1,1-Dimethylethyl N-(3R)-3-piperidinylcarbamate

Linagliptin intermediate (R)-(+)-3-tert-Butoxycarbonylaminopiperidine

(R) -3-Boc aminopyridine

R-Boc-Amino-Piperidine

BOC-R-3-AMINOPIPERIDINE

(R)-3-Boc-aminopiperidine (Alogliptin Impurity)

CAS:309956-78-3

(R)-3-(Boc-amino)piperidine

309956-78-3

Piperidine Series

N-BOC

pharmacetical

Piperidine