D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)-

Product Name: D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)-
CAS No.: 114676-59-4
Chemical Name: D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)-
Synonyms: Cis-D-Hyp-OMe.HC;Cis-D-Hyp-OMe.HCl;D-Proline, 4-Hydroxy;Cis-4-Hydroxy-D-proline Methyl ester HCl;(4R)-4-Hydroxy-D-proline methyl ester HCl;Methyl cis-4-Hydroxy-D-proline Hydrochloride;Methyl 4-hydroxypyrrolidine-2-carboxylate HCl;D-Proline, 4-hydroxy-, methyl ester (hydrochloride);Cis-4-hydroxy-proline Methyl ester hydrochloride -D-;D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1
CBNumber: CB61872286
Molecular Formula: C6H11NO3.ClH
Formula Weight: 181.618
MOL File: 114676-59-4.mol

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D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)- Property

Melting point:: 121-123℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
color: White
optical activity: 10.30(C=1.00g/100ml MEOH)

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: M323390
Product name: (2R,4R)-Methyl4-hydroxypyrrolidine-2-carboxylatehydrochloride
Packaging: 100mg
Price: $55
Updated: 2021/12/16

AK Scientific

Product number: Z3901
Product name: (2R,4R)-Methyl4-hydroxypyrrolidine-2-carboxylatehydrochloride
Packaging: 1g
Price: $14
Updated: 2021/12/16

Apolloscientific

Product number: OR17883
Product name: Methyl(2R,4R)-4-hydroxypyrrolidine-2-carboxylatehydrochloride
Packaging: 1g
Price: $15
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H29-5-X1
Product name: Methyl (2R,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride
Packaging: 1g
Price: $23
Updated: 2021/12/16

ChemScene

Product number: CS-M0680
Product name: (2R,4R)-methyl4-hydroxypyrrolidine-2-carboxylatehydrochloride
Packaging: 25g
Price: $112
Updated: 2021/12/16

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D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)- Chemical Properties,Usage,Production

Uses

D-Proline, 4-hydroxy-, methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). D-Proline, 4-hydroxy-, methyl ester hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2

Synthesis

67-56-1

2584-71-6

114676-59-4

To a stirred solution of cis-4-hydroxy-D-proline (10.0 g, 76.3 mmol, 1 eq.) in methanol (300 mL) was slowly added thionyl chloride (10.0 mL, excess) over 1.5 min at 0 °C. The reaction mixture was gradually warmed to 23 °C and stirred continuously for 16 hours. Upon completion of the reaction, the mixture was concentrated under reduced pressure to afford (2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid methyl ester hydrochloride as a white solid (15.9 g, 100% yield).

IC 50

Non-cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. DOI:10.1038/nrd.2016.268
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277

D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)- Preparation Products And Raw materials

Raw materials

Preparation Products

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D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)- Suppliers

China 89 India 4 United Kingdom 2 United States 10 Global 105

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View Lastest Price from D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)- manufacturers

Qingdao RENAS Polymer Material Co., Ltd.

Product: D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)- 114676-59-4
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2024-11-01

Career Henan Chemical Co

Product: D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)- 114676-59-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-07

114676-59-4, D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)-Related Search:

(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate Methyl pyrrolidine-2-carboxylate hydrochloride (R)-(-)-3-Pyrrolidinol hydrochloride 3-Pyrrolidinol Methyl L-prolinate hydrochloride H-CIS-HYP-OME HCL cis-4-Hydroxy-D-proline hydrochloride Methyl (S)-(+)-3-hydroxybutyrate (R)-2-Methylpyrrolidine hydrochloride D-Proline DIETHANOLAMINE HYDROCHLORIDE (S)-(+)-2-(METHOXYMETHYL)PYRROLIDINE cis-4-Hydroxy-D-proline CIS-4-HYDROXY-D-PROLINE METHYL ESTER D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)- ALLO-D-HYDROXYPROLINE ETHYL ESTER HYDROCHLORIDE METHYL D-HOMOALANINATE HCL AKOS 320

D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)-

Methyl (2R,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride

(2R,4R)-4-Hydroxy-2-(methoxycarbonyl)pyrrolidine hydrochloride, cis-4-Hydroxy-D-proline methyl ester hydrochloride

Methyl 4-hydroxypyrrolidine-2-carboxylate HCl

D-Proline, 4-hydroxy-, Methyl ester, hydrochloride, (4R)-

Cis-4-Hydroxy-D-proline Methyl ester HCl

(2R,4R)-cis-4-hydroxy-D-proline methyl ester hydrochloride

Cis-D-Hyp-OMe.HCl

Methyl cis-4-Hydroxy-D-proline Hydrochloride

(2R,4R)-4-Hydroxypyrrolidine-2-carboxylic acid methyl ester hydrochloride

Cis-4-hydroxy-proline Methyl ester hydrochloride -D-

D-Proline, 4-Hydroxy

D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1

Cis-D-Hyp-OMe.HC

D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4...

D-Proline, 4-hydroxy-, methyl ester (hydrochloride)

(4R)-4-hydroxy-D-Proline methyl ester hydrochloride (1:1)

(4R)-4-Hydroxy-D-proline methyl ester HCl

(2R,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate Hydrochloride/CIS-4-HYDROXY-D-PROLINE METHYL ESTER Hydrochloride

114676-59-4