Oxazole-4-carbaldehyde
Uses- Product Name
- Oxazole-4-carbaldehyde
- CAS No.
- 118994-84-6
- Chemical Name
- Oxazole-4-carbaldehyde
- Synonyms
- 4-FORMYLOXAZOLE;4-Formyl-1,3-oxazole;oxazol-4-carbaldehyde;OXAZOLE-4-CARBALDEHYDE;4-OXAZOLECARBOXALDEHYDE;Oxazole-4-carboxaldehyde;4-Oxazolecarboxaldehyde>1,3-oxazole-4-carbaldehyde;4-Oxazolecarboxaldehyde 97%;1,3-Oxazole-4-carboxaldehyde
- CBNumber
- CB6194334
- Molecular Formula
- C4H3NO2
- Formula Weight
- 97.07
- MOL File
- 118994-84-6.mol
Oxazole-4-carbaldehyde Property
- Melting point:
- 57-61 °C
- Boiling point:
- 184.7±13.0 °C(Predicted)
- Density
- 1.258±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- -1.49±0.10(Predicted)
- color
- Yellow
- InChI
- InChI=1S/C4H3NO2/c6-1-4-2-7-3-5-4/h1-3H
- InChIKey
- JBWIIXBEPINWPB-UHFFFAOYSA-N
- SMILES
- O1C=C(C=O)N=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 697915
- Product name
- 4-Oxazolecarboxaldehyde
- Purity
- 97%
- Packaging
- 250mg
- Price
- $205
- Updated
- 2025/07/31
- Product number
- 697915
- Product name
- 4-Oxazolecarboxaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $308
- Updated
- 2025/07/31
- Product number
- O0453
- Product name
- 4-Oxazolecarboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 200mg
- Price
- $91
- Updated
- 2021/12/16
- Product number
- O0453
- Product name
- 4-Oxazolecarboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $312
- Updated
- 2021/12/16
- Product number
- O990188
- Product name
- Oxazole-4-carbaldehyde
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
Oxazole-4-carbaldehyde Chemical Properties,Usage,Production
Uses
Oxazole-4-carboxaldehyde is mainly used in laboratory organic synthesis and in chemical and pharmaceutical research and development processes.
Synthesis
155742-48-6
118994-84-6
The general procedure for the synthesis of oxazole-4-carbaldehyde from 4-oxazolemethanol was as follows: a solution of anhydrous dichloromethane (200 mL) with dimethylsulfoxide (DMSO, 19.3 mL, 272 mmol) was added slowly and dropwise to a solution of anhydrous dichloromethane (200 mL) with oxalyl chloride (17.3 mL, 204 mmol) at -63 °C. The reaction mixture was stirred at -63 °C for 15 min before adding an anhydrous dichloromethane (200 mL) solution of 4-oxazole methanol (13.5 g, 204 mmol) with a controlled dropwise addition time of 15 min. Stirring was continued at -63 °C for 60 min, followed by the addition of triethylamine (Et3N, 53.1 mL, 381 mmol). The reaction mixture was gradually warmed up to room temperature. Upon completion of the reaction, the mixture was combined with 10% aqueous citric acid solution and extracted with dichloromethane (4 times) and ethyl acetate (2 times). The organic phases were combined, washed with a small amount of saturated aqueous sodium bicarbonate solution and extracted again with dichloromethane (3 times) and ethyl acetate (3 times). All organic phases were combined, dried with magnesium sulfate (MgSO4), filtered and the solvent was removed under reduced pressure. The residue was purified by column chromatography (eluent: ether/petroleum ether, ratio tapered from 1:1 to 2:1, to 4:1 and finally 1:0) to give oxazole-4-carbaldehyde (11.9 g, 86% yield). Thin layer chromatography (TLC) showed an Rf value of 0.65 (Expander: methanol/dichloromethane, 1:9).
References
[1] Patent: WO2006/21402, 2006, A1. Location in patent: Page/Page column 34
[2] Patent: WO2005/105802, 2005, A1. Location in patent: Page/Page column 109-110
Oxazole-4-carbaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
Oxazole-4-carbaldehyde Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from Oxazole-4-carbaldehyde manufacturers
- Product
- 4-Oxazolecarboxaldehyde 118994-84-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 100 tons
- Release date
- 2022-01-14
- Product
- Oxazole-4-carbaldehyde 118994-84-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- Oxazole-4-carbaldehyde 118994-84-6
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-21