ChemicalBook > CAS DataBase List > Tetrahydroberberine

Tetrahydroberberine

Product Name: Tetrahydroberberine
CAS No.: 522-97-4
Chemical Name: Tetrahydroberberine
Synonyms: THB;Cadine;Nsc94918;CANADINE;l-Canadine;AKOS 213-56;DL-CANADINE;tetrahedron;Canadine-RM;Xanthopuccine
CBNumber: CB6195104
Molecular Formula: C20H21NO4
Formula Weight: 339.39
MOL File: 522-97-4.mol

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Tetrahydroberberine Property

Melting point:: 166.5 °C
Boiling point:: 476.1±45.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO: >10 mg/mL, soluble
form: solid
pka: 6.53±0.20(Predicted)
color: yellow
biological source: (Corydalis yanhusuo)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 36
WGK Germany: 3
Toxicity: LD50 in mice (mg/kg): 940 orally; 790 s.c.; 100 i.v. (Sadritdinov, Sultanov)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: C175175
Product name: Canadine
Packaging: 10mg
Price: $160
Updated: 2021/12/16

TRC

Product number: C175175
Product name: Canadine
Packaging: 100mg
Price: $1295
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC19659
Product name: Canadine
Packaging: 2mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-4253
Product name: Tetrahydroberberine
Purity: 99.70%
Packaging: 5mg
Price: $82
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC19659
Product name: Canadine
Packaging: 5mg
Price: $120
Updated: 2021/12/16

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Tetrahydroberberine Chemical Properties,Usage,Production

Chemical Properties

Pale yellow crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Phellodendron chinense, Corydalis yanhusuo root tuber, and Rhizoma Corydalis.

Uses

Canadine is a protoberberine alkaloid which potently block functional KATP channels natively expressed on midbrain dopamine neurons. Canadine is used for treatment of degenerative diseases or conditions associated with KATP channel signaling.

Uses

Tetrahydroberberine is a protoberberine alkaloid which potently block functional KATP channels natively expressed on midbrain dopamine neurons. Tetrahydroberberine is used for treatment of degenerative diseases or conditions associated with KATP channel signaling.

Definition

ChEBI: A berberine alkaloid that is 5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline substituted by methoxy groups at positions 9 and 10.

Biological Activity

Dopamine receptor antagonist; nicotinic acetylcholine receptor (α4β2, α4β4, α7, α1β, 1γδ) modulator; induces clearance of low-density lipoprotein in mice.

Tetrahydroberberine (Canadine), an isoquinoline alkaloid isolated from corydalis tuber, is a potent dopamine D2 receptor antagonist (pKi = 6.08) and nicotinic acetylcholine receptor (α4β2, α4β4, α7, α1β, 1γδ) modulator. Tetrahydroberberine alleviates high-f at diet-induced hyperlipidemia and induces clearance of low-density lipoprotein and intermediate-density lipoprotein in mice.

in vivo

Tetrahydroberberine (30 μg/kg; IV) causes a dramatic increase in gastric regulatory capacity in beagle dogs, significantly enhances gastric contractility and shortens contraction intervals in rats, and enhances gastric motility function in the upper gastrointestinal tract^[1].

Tetrahydroberberine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Tetrahydroberberine manufacturers

Dideu Industries Group Limited

Product: Tetrahydroberberine 522-97-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-21

Shaanxi Dideu Medichem Co. Ltd

Product: Tetrahydroberberine 522-97-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 800 tons
Release date: 2020-05-01

Career Henan Chemical Co

Product: TETRAHYDROBERBERINE 522-97-4
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10000kg
Release date: 2018-08-10

522-97-4, TetrahydroberberineRelated Search:

(-)-Huperzine A Leflunomide Formoterol fumarate dihydrate Artemisinin Andrographolide Berbamine hydrochloride BERBERINE CHLORIDE Rotundine epiberberine Coptisine chloride Berberine hydrochloride TETRAHYDROBERBERINE(CANADINE)(P),TETRAHYDROBERBERINE(CANADINE)(P) 7-(4-chlorobenzyl)-7,8,13,13a-tetrahydroberberine DL-TETRAHYDROBERBERINE,TETRAHYDROBERBERINE,CANADINE,DL-CANADINE .Alpha.-Canadine methochloride 1-tetrahydroberberine-camphor sulfonate canadine hydrochloride (D,L)-TETRAHYDROBERBERINE(CANADINE),(D,L)-TETRAHYDROBERBERINE(CANADINE)

(13aR)-5,8,13,13a-Tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine

l-Canadine

l-Tetrahydroberberine

l-Xanthopuccine

6H-Benzo[G]-1,3-benzodioxolo[5,6-A]quinolizine, 5,8,13,13A-tetrahydro-9,10-dimethoxy-

Berberine, tetrahydro-

Berbine, 9,10-dimethoxy-2,3-(methylenedioxy)-

Nsc94918

Xanthopuccine

Tetrahydroberberine,THB

9,10-DiMethoxy-2,3-(Methylenedioxy)berbine

9-Deoxy-16,17-dihydroberberine

Tetrahydroberberine, BR

TETRAHYDROBERBERINE

Tetrahydroberberine, Canadine

Canadine, THB, 5,8,13,13a-Tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-alpha]quinolizine

5,8,13,13a-Tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine

Tetrahydroberberine, 98%, from Coptis chinensis Franch.

dl-Tetrahydroberberine 〔dl-Canadine〕

9,10-DIMETHOXY-5,8,13,13A-TETRAHYDRO-6H-[1,3]DIOXOLO[4,5-G]ISOQUINO[3,2-A]ISOQUINOLINE

AKOS 213-56

5,8,13,13A-TETRAHYDRO-9,10-DIMETHOXY-6H-BENZO[G]-1,3-BENZODIOXOLO[5,6-ALPHA]QUINOLIZINE

CANADINE

DL-TETRAHYDROBERBERINE

DL-CANADINE

THB

5,8,13,13a-tetrahydro-9,10-dimethoxy-6H-benzo[g]benzo-1,3-dioxolo[5,6-a]quinolizine

Tetrahydroberberine USP/EP/BP

tetrahedron

5,8,13,13a-tetrahydro-9,10-dimethoxy-6H-benzo[g]benzo-1,3-di...

9,10-Dimethoxy-5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline

Tetrahydroberine

Canadine-RM

Certified Reference Material of Canadine

Cadine

522-97-4

C20H21O4N

Inhibitors

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

chemical reagent

pharmaceutical intermediate

phytochemical

Aromatics

Heterocycles

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