4-Amino-2-chloropyrimidine
- Product Name
- 4-Amino-2-chloropyrimidine
- CAS No.
- 7461-50-9
- Chemical Name
- 4-Amino-2-chloropyrimidine
- Synonyms
- 2-CHLOROPYRIMIDIN-4-AMINE;2-CHLORO-4-PYRIMIDINAMINE;4-AMINO-2-CHLOROPYRIMIDINE;2-CHLORO-4-AMINOPYRIMIDINE;4-Pyrimidinamine, 2-chloro-;2-CHLOROPYRIMIDIN-4-YLAMINE;4-Amino-2-chloropyrimidin...;4-Amino-2-chloropyrimidine >4-Amino-2-chloropyrimidine ,97%;4-Pyrimidinamine, 2-chloro- (9CI)
- CBNumber
- CB6195861
- Molecular Formula
- C4H4ClN3
- Formula Weight
- 129.55
- MOL File
- 7461-50-9.mol
4-Amino-2-chloropyrimidine Property
- Melting point:
- 197-205 °C
- Boiling point:
- 338.8±15.0 °C(Predicted)
- Density
- 1.437±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 2.30±0.10(Predicted)
- color
- White to Light yellow
- InChI
- InChI=1S/C4H4ClN3/c5-4-7-2-1-3(6)8-4/h1-2H,(H2,6,7,8)
- InChIKey
- LPBDZVNGCNTELM-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC(N)=N1
- CAS DataBase Reference
- 7461-50-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-36-22
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT-HARMFUL
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 679062
- Product name
- 4-Amino-2-chloropyrimidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $59.1
- Updated
- 2023/06/20
- Product number
- A2719
- Product name
- 4-Amino-2-chloropyrimidine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $39
- Updated
- 2025/07/31
- Product number
- A2719
- Product name
- 4-Amino-2-chloropyrimidine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $150
- Updated
- 2025/07/31
- Product number
- A617743
- Product name
- 4-Amino-2-chloropyrimidine
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- A617743
- Product name
- 4-Amino-2-chloropyrimidine
- Packaging
- 5g
- Price
- $130
- Updated
- 2021/12/16
4-Amino-2-chloropyrimidine Chemical Properties,Usage,Production
Chemical Properties
White to light brown solid
Uses
4-Amino-2-chloropyrimidine is a chloropyrimidine compound, which is widely used in the synthesis of various medicines and pesticides. It can be used to transform functional groups, such as amino groups, or to remove chlorine by hydrogenolysis; chlorine can also be used to couple various carbon-carbon bonds.
Synthesis
3934-20-1
7461-50-9
3993-78-0
2,4-Dichloropyrimidine (1.0 g, 6.7 mmol) was used as starting material and 28% w/v aqueous ammonium hydroxide solution (20 mL) was added. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The obtained residue was dried and subsequently purified by fast column chromatography (FCC) with the eluent being chloroform solution containing 2-10% ethanol, resulting in the isolation of 2-amino-4-chloropyrimidine and 2-chloro-4-aminopyrimidine. Product yields: 200 mg of 2-amino-4-chloropyrimidine in 23% yield and 600 mg of 2-chloro-4-aminopyrimidine in 69% yield.
References
[1] Patent: WO2010/20556, 2010, A1. Location in patent: Page/Page column 62
[2] Journal of the American Chemical Society, 2003, vol. 125, # 33, p. 9970 - 9982
[3] Tetrahedron, 2010, vol. 66, # 6, p. 1280 - 1288
[4] Patent: WO2006/114409, 2006, A1. Location in patent: Page/Page column 18
[5] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 14, p. 1973 - 1978
4-Amino-2-chloropyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Amino-2-chloropyrimidine manufacturers
- Product
- 4-Amino-2-chloropyrimidine 7461-50-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-14
- Product
- 4-Amino-2-chloropyrimidine 7461-50-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 4-Amino-2-chloropyrimidine 7461-50-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09