Uses
ChemicalBook > CAS DataBase List > (S)-1-Boc-3-hydroxypiperidine

(S)-1-Boc-3-hydroxypiperidine

Uses
Product Name
(S)-1-Boc-3-hydroxypiperidine
CAS No.
143900-44-1
Chemical Name
(S)-1-Boc-3-hydroxypiperidine
Synonyms
tert-butyl (S)-3-hydroxypiperidine-1-carboxylate;(S)-3-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;Ibrutinib Interm 0441;1,1-DiMethylethy;(S)-BOC-piperidinol;Ilutinib impurity 7;(S)-1-BOC-3-PIPERIDINOL;（S）-N-BOC-3-piperidinol;(S)-1-BOC-Piperidin-3-ol;(S)-1-Boc-3-Hdroxypiperidine
CBNumber
CB6197360
Molecular Formula
C10H19NO3
Formula Weight
201.26
MOL File
143900-44-1.mol
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(S)-1-Boc-3-hydroxypiperidine Property

Melting point:
34-40 °C
Boiling point:
292.3±33.0 °C(Predicted)
Density 
1.107±0.06 g/cm3(Predicted)
Flash point:
110 °C
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Soluble in methanol.
pka
14.74±0.20(Predicted)
form 
Powder or Crystalline Powder
color 
White to tan
optical activity
[α]22/D +10.0°, c = 1 in chloroform
InChI
InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(12)7-11/h8,12H,4-7H2,1-3H3/t8-/m0/s1
InChIKey
UIJXHKXIOCDSEB-QMMMGPOBSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC[C@H](O)C1
CAS DataBase Reference
143900-44-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
WGK Germany 
3
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
687367
Product name
(S)-1-Boc-3-hydroxypiperidine
Purity
97%
Packaging
1g
Price
$112
Updated
2024/03/01
TCI Chemical
Product number
B4446
Product name
(S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine
Purity
>98.0%(GC)
Packaging
1g
Price
$21
Updated
2024/03/01
TCI Chemical
Product number
B4446
Product name
(S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine
Purity
>98.0%(GC)
Packaging
5g
Price
$64
Updated
2024/03/01
Alfa Aesar
Product number
H52771
Product name
(S)-1-Boc-3-hydroxypiperidine, 97%
Packaging
1g
Price
$50.65
Updated
2024/03/01
Alfa Aesar
Product number
H52771
Product name
(S)-1-Boc-3-hydroxypiperidine, 97%
Packaging
5g
Price
$207.65
Updated
2024/03/01
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(S)-1-Boc-3-hydroxypiperidine Chemical Properties,Usage,Production

Uses

(S)-1-Boc-3-hydroxypiperidine is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies. Synthesis of pharmaceutical intermediates including ibrutinib, the API of the newly approved drug Imbruvica, for the treatment of lymphoma.

Description

(S)-1-Boc-3-hydroxypiperidine, alias (S)-N-Boc-3-hydroxypiperidine (S-NBHP) is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies.S-NBHP can be prepared in a variety of ways such as chemically or biocatalytically. S-NBHP can be prepared in various ways, such as chemical synthesis or biocatalysis. Biocatalysis is an efficient process for the reduction of N-Boc-piperidin-3-one by recombinant keto reductase (KRED) catalytic to obtain optically pure S-NBHP using 99% yield. The asymmetric reduction of N-Boc-piperidin-3-one (NBPO) to (S)-NBHP can also be catalysed by a reductase (YDR541C) isolated from Saccharomyces cerevisiae in 99% yield.

Chemical Properties

White powder

Uses

(S)-1-Boc-3-hydroxypiperidine is used as pharmaceutical intermediate.

Uses

A piperidine derivative with an amine protecting group, (S)-1-Boc-3-hydroxypiperidine can be used in the preparation of biologically active compounds such as antagonists of the human P2X7 receptor and selective irreversible inhibitors for bruton's tyrosine kinase.

(S)-1-Boc-3-hydroxypiperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (S)-1-Boc-3-hydroxypiperidine manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
(S)-1-Boc-3-hydroxypiperidine 143900-44-1
Price
US $50.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-12-06
Shanghai UCHEM Inc.
Product
(S)-1-Boc-3-hydroxypiperidine 143900-44-1
Price
US $63.00-308.00/g
Min. Order
100g
Purity
0.99
Supply Ability
100kg
Release date
2023-10-26
Shanghai Joiny Pharmaceutical Co.,LTD
Product
(S)-1-Boc-3-hydroxypiperidine 143900-44-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2024-12-05

143900-44-1, (S)-1-Boc-3-hydroxypiperidineRelated Search:

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