ChemicalBook > CAS DataBase List > 4-Nitrophthalic anhydride

4-Nitrophthalic anhydride

Product Name
4-Nitrophthalic anhydride
CAS No.
5466-84-2
Chemical Name
4-Nitrophthalic anhydride
Synonyms
4-nitro-anhydride;TIMTEC-BB SBB008431;Apremilast Impurity 89;p-NitroPhthalicAnhydride;4-nitro-phthalicanhydrid;4-NITROPHTHALIC ANHYDRIDE;5-Nitrophthalic anhydride;4-nitro pthalic anhydride;4-NitrophthalicAnhydride>4-Nitro-o-phthalicanhydride
CBNumber
CB6207807
Molecular Formula
C8H3NO5
Formula Weight
193.11
MOL File
5466-84-2.mol
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4-Nitrophthalic anhydride Property

Melting point:
116-120 °C(lit.)
Boiling point:
197 °C / 8mmHg
Density 
1.6392 (rough estimate)
refractive index 
1.4700 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly)
form 
Solid
color 
Pale Beige
Water Solubility 
Hydrolysis
Sensitive 
Moisture Sensitive
BRN 
179682
CAS DataBase Reference
5466-84-2(CAS DataBase Reference)
NIST Chemistry Reference
4-Nitrophthalic anhydride(5466-84-2)
EPA Substance Registry System
5-Nitrophthalic anhydride (5466-84-2)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/22
Safety Statements 
26-36-36/37/39-22
WGK Germany 
3
RTECS 
TI3328000
F 
10-21
TSCA 
Yes
HS Code 
29173990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
238201
Product name
4-Nitrophthalic anhydride
Purity
92%
Packaging
5g
Price
$46.4
Updated
2023/06/20
Sigma-Aldrich
Product number
238201
Product name
4-Nitrophthalic anhydride
Purity
92%
Packaging
25g
Price
$192
Updated
2023/06/20
TCI Chemical
Product number
N0246
Product name
4-Nitrophthalic Anhydride
Purity
>97.0%(T)
Packaging
25g
Price
$156
Updated
2024/03/01
TCI Chemical
Product number
N0246
Product name
4-Nitrophthalic Anhydride
Purity
>97.0%(T)
Packaging
100g
Price
$454
Updated
2024/03/01
Alfa Aesar
Product number
L08020
Product name
4-Nitrophthalic anhydride, tech. 90%
Packaging
5g
Price
$57.65
Updated
2024/03/01
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4-Nitrophthalic anhydride Chemical Properties,Usage,Production

Chemical Properties

off-white to light yellow-brown powder. Soluble in hot alcohol, hot acetic acid and acetone, insoluble in water.

Uses

4-Nitrophthalic anhydride is used an an intermediate for the synthesis of a benzimidazole PARP inhibitor I (succinate salt) (ABT-472).

Uses

5-Nitrophthalic Anhydride is used in the preparation of phthalic acids as well as compounds with anticonvulsant activities.

Preparation

4-Nitrophthalic anhydride is synthesized by hydrolysis of 4-nitrophthalimide and then dehydration. The 4-nitrophthalimide was added to the sodium hydroxide solution, heated and boiled for 15min. Adjust pH to 6-8 with nitric acid, and add nitric acid to boil for 5 min. Cooling, filtering, the filtrate was extracted with ether, the extract was dried and then the ether was evaporated, that is, 4-Nitrophthalic anhydride crystals were precipitated. Yield 95%.

General Description

Yellow powder.

Air & Water Reactions

Reacts with water. The organic acids produced by this reaction are significantly more soluble in water.

Reactivity Profile

4-Nitrophthalic anhydride reacts exothermically with water. The reactions are usually slow, but might become violent if local heating accelerates their rate. Acids accelerate the reaction with water. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases.

Fire Hazard

Flash point data for 4-Nitrophthalic anhydride are not available, however 4-Nitrophthalic anhydride is probably combustible.

Purification Methods

Distil the anhydride in a vacuum and/or recrystallise it from *C6H6 or Et2O/pet ether. Dry it in vacuo. It forms addition compounds with anthracene (m 118o), and phenanthrene (m 96o). [Beilstein 17 III/IV 6150, 17/11 V 267.]

Precautions

Moisture Sensitive. Store away from strong bases and oxidizing agents. Incompatible with water, bases, strong acids and oxidizing agents.

4-Nitrophthalic anhydride Preparation Products And Raw materials

Raw materials

4-Nitrophthalic acid 4-Nitrophthalimide

Preparation Products

Fluorescein isothiocyanate
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4-Nitrophthalic anhydride Suppliers

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View Lastest Price from 4-Nitrophthalic anhydride manufacturers

Asia Chem I and E (Jiangsu) Co Ltd
Product
4-Nitrophthalic anhydride 5466-84-2
Price
US $83.72/Kg/Drum
Min. Order
25Kg/Drum
Purity
98.00%HPLC
Supply Ability
5tons/month
Release date
2021-09-22
Hebei Chuanghai Biotechnology Co,.LTD
Product
4-Nitrophthalic anhydride 5466-84-2
Price
US $10.70/kg
Min. Order
10kg
Purity
99%
Supply Ability
10000kg
Release date
2024-08-23
HONG KONG IPURE BIOLOGY CO.,LIMITED
Product
4-nitrophthalic anhydride 5466-84-2
Price
US $1.00/BOU/Drum
Min. Order
1KG
Purity
98%
Supply Ability
1kg
Release date
2020-11-24

5466-84-2, 4-Nitrophthalic anhydrideRelated Search:

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