ChemicalBook > CAS DataBase List > 4-Nitrophthalic anhydride

4-Nitrophthalic anhydride

Product Name
4-Nitrophthalic anhydride
CAS No.
5466-84-2
Chemical Name
4-Nitrophthalic anhydride
Synonyms
4-nitro-anhydride;TIMTEC-BB SBB008431;Apremilast Impurity 89;p-NitroPhthalicAnhydride;4-nitro-phthalicanhydrid;4-NITROPHTHALIC ANHYDRIDE;5-Nitrophthalic anhydride;4-nitro pthalic anhydride;4-NitrophthalicAnhydride>4-Nitro-o-phthalicanhydride
CBNumber
CB6207807
Molecular Formula
C8H3NO5
Formula Weight
193.11
MOL File
5466-84-2.mol
More
Less

4-Nitrophthalic anhydride Property

Melting point:
116-120 °C(lit.)
Boiling point:
197 °C / 8mmHg
Density 
1.6392 (rough estimate)
refractive index 
1.4700 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly)
form 
Solid
color 
Pale Beige
Water Solubility 
Hydrolysis
Sensitive 
Moisture Sensitive
BRN 
179682
CAS DataBase Reference
5466-84-2(CAS DataBase Reference)
NIST Chemistry Reference
4-Nitrophthalic anhydride(5466-84-2)
EPA Substance Registry System
5-Nitrophthalic anhydride (5466-84-2)
More
Less

Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/22
Safety Statements 
26-36-36/37/39-22
WGK Germany 
3
RTECS 
TI3328000
10-21
TSCA 
Yes
HS Code 
29173990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
238201
Product name
4-Nitrophthalic anhydride
Purity
92%
Packaging
5g
Price
$46.4
Updated
2023/06/20
Sigma-Aldrich
Product number
238201
Product name
4-Nitrophthalic anhydride
Purity
92%
Packaging
25g
Price
$192
Updated
2023/06/20
TCI Chemical
Product number
N0246
Product name
4-Nitrophthalic Anhydride
Purity
>97.0%(T)
Packaging
25g
Price
$156
Updated
2024/03/01
TCI Chemical
Product number
N0246
Product name
4-Nitrophthalic Anhydride
Purity
>97.0%(T)
Packaging
100g
Price
$454
Updated
2024/03/01
Alfa Aesar
Product number
L08020
Product name
4-Nitrophthalic anhydride, tech. 90%
Packaging
5g
Price
$57.65
Updated
2024/03/01
More
Less

4-Nitrophthalic anhydride Chemical Properties,Usage,Production

Chemical Properties

off-white to light yellow-brown powder. Soluble in hot alcohol, hot acetic acid and acetone, insoluble in water.

Uses

4-Nitrophthalic anhydride is used an an intermediate for the synthesis of a benzimidazole PARP inhibitor I (succinate salt) (ABT-472).

Uses

5-Nitrophthalic Anhydride is used in the preparation of phthalic acids as well as compounds with anticonvulsant activities.

Preparation

4-Nitrophthalic anhydride is synthesized by hydrolysis of 4-nitrophthalimide and then dehydration. The 4-nitrophthalimide was added to the sodium hydroxide solution, heated and boiled for 15min. Adjust pH to 6-8 with nitric acid, and add nitric acid to boil for 5 min. Cooling, filtering, the filtrate was extracted with ether, the extract was dried and then the ether was evaporated, that is, 4-Nitrophthalic anhydride crystals were precipitated. Yield 95%.

General Description

Yellow powder.

Air & Water Reactions

Reacts with water. The organic acids produced by this reaction are significantly more soluble in water.

Reactivity Profile

4-Nitrophthalic anhydride reacts exothermically with water. The reactions are usually slow, but might become violent if local heating accelerates their rate. Acids accelerate the reaction with water. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases.

Fire Hazard

Flash point data for 4-Nitrophthalic anhydride are not available, however 4-Nitrophthalic anhydride is probably combustible.

Purification Methods

Distil the anhydride in a vacuum and/or recrystallise it from *C6H6 or Et2O/pet ether. Dry it in vacuo. It forms addition compounds with anthracene (m 118o), and phenanthrene (m 96o). [Beilstein 17 III/IV 6150, 17/11 V 267.]

Precautions

Moisture Sensitive. Store away from strong bases and oxidizing agents. Incompatible with water, bases, strong acids and oxidizing agents.

4-Nitrophthalic anhydride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-Nitrophthalic anhydride Suppliers

Jiangsu Lingyi Chemical Technology Co., Ltd.
Tel
0523-87653988 15961022226
Email
214703666@qq.com
Country
China
ProdList
117
Advantage
58
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Greenspring Biotechnology (Jiangsu) Co., Ltd.
Tel
0523-87726088 13705266400
Fax
0523-87653988
Email
sun1@sunmy.com
Country
China
ProdList
116
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9555
Advantage
66
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11660
Advantage
64
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9816
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-0712-2580635 15527768850
Email
1791901229@qq.com
Country
China
ProdList
8850
Advantage
52
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
BEST-REAGENT
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11726
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14443
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4531
Advantage
62
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11714
Advantage
57
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9725
Advantage
55
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17779
Advantage
75
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6139
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6181
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22519
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
24835
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9552
Advantage
55
Quzhou Juhua Friendship Co., Ltd
Tel
0570-3066667
Fax
0570-3063388
Country
China
ProdList
3933
Advantage
58
Hubei XinyuanShun Chemical Co., Ltd.
Tel
13971561712, 13995564702, 027-50664929
Fax
027-50664927
Email
hbeixys2001@163.com
Country
China
ProdList
3123
Advantage
55
Huainan Kedi Chemical Factory
Tel
0554-2106669
Fax
0554-2666215
Email
sales1@kedichem.com
Country
China
ProdList
4928
Advantage
55
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41132
Advantage
60
Zhengzhou ALFA Chemical Co., Ltd.
Tel
0371-53732842 15981811963
Fax
0371-86239377
Email
1758257485@qq.com
Country
China
ProdList
951
Advantage
56
BeiJing TOP Science Bio-Technology Co., Ltd.
Tel
+86-13439059536 +86-15201677815
Country
China
ProdList
291
Advantage
58
Shanghai Worldyang Chemical Co.,Ltd.
Tel
021-021-56795766
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9353
Advantage
58
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ:800101999
Email
cdhxsj@163.com
Country
China
ProdList
13358
Advantage
58
Shanghai Balmxy Pharmaceutical Co., Ltd
Tel
021-24206007 13764915196
Fax
86-021-23027023
Email
sales@balmxy.com
Country
China
ProdList
6710
Advantage
55
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10287
Advantage
55
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15873
Advantage
55
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9912
Advantage
50
SHANGHAI BANGCHENG CHEMICAL Co.,Ltd.
Tel
021-69106960 13701823733
Fax
021-69106780
Email
13701823733@163.com
Country
China
ProdList
4776
Advantage
60
Shanghai Yongye Biotechnology Co., Ltd.
Tel
86-021-61559134 15921386130
Fax
021-55068248
Email
3423497944@qq.com
Country
China
ProdList
8147
Advantage
55
Beijing Xinsavi Chemical Technology Co., Ltd.
Tel
010-56218822 13717722232
Fax
010-56218800
Email
xinsavichem@163.com
Country
China
ProdList
3201
Advantage
56
Beijing Holiyang Chemical Co. Ltd.
Tel
13718199399
Fax
QQ : 206661479
Email
holiyangchem@163.com
Country
China
ProdList
3388
Advantage
56
Shanghai YouPeng Chemical Co. Ltd.
Tel
021-69005955 13701776567
Fax
021-69005775
Email
youpengchem@163.com
Country
China
ProdList
4304
Advantage
56
Sichuan Hainuowei Technology Co. Ltd.
Tel
13708085536
Fax
QQ : 121102042
Email
hanovichem@163.com
Country
China
ProdList
3390
Advantage
56
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 18112977050
Email
cb6@aikonchem.com
Country
China
ProdList
16687
Advantage
50
Shanghai TongYuan Chemical Co., Ltd.
Tel
021-021-69182866 13701855675
Fax
021-69182022
Email
tongyuanchem@126.com
Country
China
ProdList
4332
Advantage
58
Shanghai Kaisai Chemical Co., Ltd
Tel
021-33516722 13701817765
Fax
021-33516776
Email
kaisaichem@163.com
Country
China
ProdList
4752
Advantage
58
Chengdu RunZeBenTu Chemical Co., Ltd
Tel
13096311329 028-88469284 616445927
Fax
028-88469284
Email
616445927@qq.com
Country
China
ProdList
2876
Advantage
50
Beijing HuaYangZhicheng Technology Co., Ltd.
Tel
13716033033
Fax
010-56276266
Email
hanchochem@163.com
Country
China
ProdList
2960
Advantage
50
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9767
Advantage
58
More
Less

View Lastest Price from 4-Nitrophthalic anhydride manufacturers

Asia Chem I and E (Jiangsu) Co Ltd
Product
4-Nitrophthalic anhydride 5466-84-2
Price
US $83.72/Kg/Drum
Min. Order
25Kg/Drum
Purity
98.00%HPLC
Supply Ability
5tons/month
Release date
2021-09-22
Hebei Guanlang Biotechnology Co,.LTD
Product
4-Nitrophthalic anhydride 5466-84-2
Price
US $10.70/Kg/Bag
Min. Order
10g
Purity
99%
Supply Ability
10000kg
Release date
2021-08-20
HONG KONG IPURE BIOLOGY CO.,LIMITED
Product
4-nitrophthalic anhydride 5466-84-2
Price
US $1.00/BOU/Drum
Min. Order
1KG
Purity
98%
Supply Ability
1kg
Release date
2020-11-24

5466-84-2, 4-Nitrophthalic anhydrideRelated Search:


  • 5-NITRO-ISOBENZOFURAN-1,3-DIONE
  • TIMTEC-BB SBB008431
  • 1,3-Isobenzofurandione, 5-nitro-
  • 4-Nitrophthalic acid anhydride
  • 4-nitrophthalicacidanhydride
  • 4-NITROPHTHALIC ANHYDRIDE
  • 4-Nitro Phthalic Anhydride p-Nitro Phthalic Anhydride
  • 4-Nitrophthalicanhydride,95%
  • 4-Nitro-o-phthalicanhydride
  • p-NitroPhthalicAnhydride
  • 4-NITROPHTHALIC ANHYDRIDE: TECH., 90%
  • 4-nitro-phthalicanhydrid
  • 5-nitro-1,3-isobenzofurandione
  • 5-Nitro-2-benzofuran-1,3-dione
  • 5-nitro-3-isobenzofurandione
  • Phthalic anhydride, 4-nitro-
  • 5-Nitrophthalic anhydride
  • 4-Nitrophthalic anhydride,93%
  • 4-nitro-anhydride
  • 5-Nitroisobenzofuran-1,3-dione, 5-Nitrobenzo[c]furan-1,3-dione, 5-Nitro-2-benzofuran-1,3-dione
  • 4-Nitrophthalic anhydride, 93% 5GR
  • 4-amino-phthalic acid-anhydride
  • 4-NitrophthalicAnhydride&gt
  • 4-Nitrophthalic Anhydride,>98%
  • 4-nitro pthalic anhydride
  • Apremilast Impurity 89
  • 5466-84-2
  • ALDEHYDE
  • Carbonyl Compounds
  • Carboxylic Acid Anhydrides
  • Building Blocks
  • Organic Building Blocks
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Carboxylic Acid Anhydrides
  • Organic Building Blocks
  • Anhydride Monomers
  • Monomers
  • Polymer Science
  • Carbonyl Compounds