ChemicalBook > CAS DataBase List > 5-Chlorouracil

5-Chlorouracil

Product Name
5-Chlorouracil
CAS No.
1820-81-1
Chemical Name
5-Chlorouracil
Synonyms
5-CHLOROPYRIMIDINE-2,4(1H,3H)-DIONE;Fluorouracil EP Impurity E;5-Chloro-1H-pyrimidine-2,4-dione;NSC 28172;5-chloro-uraci;5-CHLOROURACIL;Uracil,5-chloro-;5-CHLORO-5-URACIL;5-Chlorouracil,99%;5-Chlorouracil,98%
CBNumber
CB6216858
Molecular Formula
C4H3ClN2O2
Formula Weight
146.53
MOL File
1820-81-1.mol
More
Less

5-Chlorouracil Property

Melting point:
>300 °C (lit.)
Density 
1.6838 (rough estimate)
refractive index 
1.6550 (estimate)
storage temp. 
2-8°C
solubility 
1 M NH4OH: soluble50mg/mL
pka
6.77±0.10(Predicted)
form 
Solid
color 
White to Off-White
Water Solubility 
2.501g/L(25 ºC)
BRN 
127173
InChI
InChI=1S/C4H3ClN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
InChIKey
ZFTBZKVVGZNMJR-UHFFFAOYSA-N
SMILES
C1(=O)NC=C(Cl)C(=O)N1
CAS DataBase Reference
1820-81-1(CAS DataBase Reference)
EPA Substance Registry System
5-Chlorouracil (1820-81-1)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-36-26
WGK Germany 
3
RTECS 
YQ9410000
HS Code 
29335995
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
224588
Product name
5-Chlorouracil
Purity
99%
Packaging
5g
Price
$92.1
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR2867
Product name
Fluorouracil Related Compound E
Purity
certified reference material, pharmaceutical secondary standard
Packaging
50MG
Price
$608
Updated
2024/03/01
Sigma-Aldrich
Product number
1279054
Product name
Fluorouracil Related Compound E
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$1210
Updated
2024/03/01
TCI Chemical
Product number
C0969
Product name
5-Chlorouracil
Purity
>98.0%(T)
Packaging
5g
Price
$62
Updated
2024/03/01
TCI Chemical
Product number
C0969
Product name
5-Chlorouracil
Purity
>98.0%(T)
Packaging
25g
Price
$180
Updated
2024/03/01
More
Less

5-Chlorouracil Chemical Properties,Usage,Production

Description

5-Chlorouracil (5-CU) may have advantages for the inhibition of undesired fibroblast proliferation taking place after surgery for glaucoma and results in filtration failure. A comparison of 5-CU and 5-fluorouracil (5-FU) cytotoxicity shows that 5-CU is approximately 1000 times less toxic to nonproliferative cells while maintaining good antimitotic activity. In addition, 5-CU induces apoptotic-controlled cell death, whereas the influence of 5-FU is by apoptonecrosis. The 5-CU apoptotic mechanism is driven mainly by the nuclear translocation of AIF and activation of the LEI/L-DNase II pathways, which are caspase-independent. In conclusion, even though 5-CU is a weaker antiproliferating agent than 5-FU, its reduced toxic side effects on the epithelium and sclera allow for its enhanced efficacy and extended reduction of IOP after filtering surgery for glaucoma. 5-CU is an effective mutagen, clastogen and toxicant, and an effective inducer of sister-chromatid exchange, and is not as sensitive to ionizing radiation as other thymine analogues[1].

Chemical Properties

white to light beige crystalline powder

Uses

5-Chlorouracil was used as a control in resazurin-based cytotoxicity assay for screening of cytotoxicity in hepatocytes and liver cell lines.

Uses

5-Chlorouracil can be used for the experimental and clinical treatment of neoplastic and viral diseases.

Definition

ChEBI: An organochlorine compound consisting of uracil having an chloro substituent at the 5-position. It is functionally related to a uracil.

General Description

The shape resonance spectra of 5-chlorouracil, obtained from fixed-nuclei elastic scattering calculations by the Schwinger multichannel method with pseudopotentials, was studied.

Purification Methods

It recrystallises from hot H2O (4g/500mL) using charcoal. [McOmie et al. J Chem Soc 3478 1955, West & Barrett J Am Chem Soc 76 3146 1954, Beilstein 24 III/IV 1231.]

References

[1] Marianne Berdugo Polak. “Controlled delivery of 5-chlorouracil using poly(ortho esters) in filtering surgery for glaucoma.” Investigative ophthalmology & visual science (2008): 2993–3003.

5-Chlorouracil Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

5-Chlorouracil Suppliers

Americas 1 Belgium 2 Canada 4 China 336 Europe 4 France 1 Germany 11 India 22 Japan 3 Russia 1 Slovakia 1 South Korea 1 Switzerland 3 Ukraine 1 United Kingdom 17 United States 54 Global 462
Jiangxi ruiya pharmaceutical co., LTD
Tel
0795-7229183; 19170706235
Email
hwp@ruiyapharma.com
Country
China
ProdList
75
Advantage
55
Jiangsu Zhongyuan Chemicals Co.,Ltd.
Tel
0513-84539538 13817775327
Email
jinjing860329@163.com
Country
China
ProdList
19
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12386
Advantage
60
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11655
Advantage
64
Nanjing Chemlin Chemical Co., Ltd
Tel
19951945301
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19185
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8835
Advantage
52
Beijing Isomersyn Technology CO;LTD
Tel
010-82954736 13391601435
Email
sales@isomersyn.com
Country
China
ProdList
3295
Advantage
57
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Tangshan Moneide Trading Co., Ltd.
Tel
0315-8309571 15633399667
Fax
+86-315-7726572
Email
sales@moneidechem.com
Country
China
ProdList
704
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
021-51613915-820 13611835272
Fax
021 51613951
Email
mmwang@sunwaypharm.cn
Country
China
ProdList
9734
Advantage
57
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
ZhengZhou HuaWen Chemical Co.Ltd
Tel
0370-2785118 17550508557
Fax
QQ：3470079902
Email
675141927@qq.com
Country
China
ProdList
3203
Advantage
55
Shanghai Sphchem Co., Ltd.
Tel
021-56491756 13512199871
Fax
021-5649-1756
Email
2819742715@qq.com
Country
China
ProdList
4001
Advantage
55
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4727
Advantage
58
Jinan Bond Chemical Technology Co., Ltd.
Tel
86-531-88280989
Fax
86-531-88280989
Email
mymail1996@126.com
Country
China
ProdList
256
Advantage
55
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4940
Advantage
60
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
5047
Advantage
50
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Wuhan Taiyicheng Biopharmaceutical Co., Ltd.
Tel
027-88320699
Fax
027-88320962
Email
tycshyy@126.com
Country
China
ProdList
297
Advantage
66
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Nanjing Norris-Pharm Technology Co., Ltd
Tel
13901585132
Fax
+86-25-52131256
Email
799750417@qq.com
Country
China
ProdList
8878
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 18021050169
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Shanghai Arbor Chemical Co., Ltd.
Tel
021-60451682 15021268886
Fax
+86-21-60451682
Email
sales@arborchemical.com
Country
China
ProdList
862
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Wuhan DKY Technology Co.,Ltd.
Tel
027-27-81302488 15972195220
Fax
027-81302088
Email
info@dkybpc.com
Country
China
ProdList
1672
Advantage
58
Hubei XinyuanShun Chemical Co., Ltd.
Tel
13971561712, 13995564702, 027-50664929
Fax
027-50664927
Email
hbeixys2001@163.com
Country
China
ProdList
3120
Advantage
55
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9978
Advantage
55
Huainan Kedi Chemical Factory
Tel
0554-2106669
Fax
0554-2666215
Email
sales1@kedichem.com
Country
China
ProdList
4924
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
Zhengzhou HongSheng Pharmaceutical Co., Ltd.
Tel
0371-13526885213 15637198702
Fax
0371-63709726
Email
xpkchem@163.com
Country
China
ProdList
3980
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18097
Advantage
56
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Changzhou Zhongji Chemical Co.,Ltd
Tel
0519-85156279-811,812
Fax
0519-85156279-816
Email
sales@czzjchem.com
Country
China
ProdList
20
Advantage
58
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9648
Advantage
58
More
Less

View Lastest Price from 5-Chlorouracil manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
5-Chlorouracil 1820-81-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-22
Hebei Weibang Biotechnology Co., Ltd
Product
5-Chlorouracil 1820-81-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-12-05
Zhuozhou Wenxi import and Export Co., Ltd
Product
5-chlorouracil 1820-81-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-26

1820-81-1, 5-ChlorouracilRelated Search:

Uracil Difluorochloromethane 5-Chlorouridine Terbacil 5-CHLORO-6-METHYLURACIL 4-AMINOPYRAZOLO[3,4-D]PYRIMIDINE 6-Chlorouracil 6-methyl-5-chlorouracil 1,3-Dimethyl-4-chlorouracil,1,3-DIMETHYL-6-CHLOROURACIL 3-Methyl-6-chlorouracil, GC 97%,3-METHYL-6-CHLOROURACIL 2,4(1H,3H)-Pyrimidinedione,5-chloro-6-(chloromethyl)-(9CI) 5-CHLORO-2'-DEOXYURIDINE 1-(3-Fluoro-2,3-dideoxy-β-D-erythro-pentofuranosyl)-5-chlorouracil 5-Chloro-2',3'-O-isopropylidene-D-uridine 5-Chloro-5'-deoxy-5'-iodo-2',3'-O-isopropylidene-D-uridine 5-Chlorouracil-15N2,13C 1,3,5-TRICHLOROURACIL 5-CHLORO-5'-DEOXYURIDINE

  • TIMTEC-BB SBB004103
  • 2,4(1H,3H)-Pyrimidinedione,5-chloro-
  • 2,4-Pyrimidinediol,5-chloro-
  • 3h)-pyrimidinedione,5-chloro-4(1h
  • 5-Chloro-1,2,3,4-tetrahydropyrimidine-2,4-dione
  • 5-Chloropyrimidine-2,4-diol
  • 5-Chlorouracil,99%
  • Fluorouracil Related CoMpound E
  • 5-Chlorouracil ReagentPlus(R), 99%
  • Fluorouracil Related Compound E (25 mg) (5-Chloropyrimidine-2,4(1H,3H)-dione)
  • 5-Chlorouracil Vetec(TM) reagent grade, 98%
  • Fluorouracil Impurity 5（Fluorouracil EP Impurity E）
  • Fluorouracil EP Impurity E
  • 5-Chlor-2,4-dihydroxypyrimidin
  • 5-Chloro-1H-pyrimidine-2,4-dione
  • 5-Chloro-2,4-pyrimidinedione
  • 5-chloro-uraci
  • Uracil,5-chloro-
  • 5-CHLORO-2,4-DIHYDROXYPYRIMIDINE
  • 5-CHLORO-5-URACIL
  • 5-CHLOROURACIL
  • 5-CHLOROPYRIMIDINE-2,4(1H,3H)-DIONE
  • 5-CHLOROURACIL,5-CHLORO-2,4-DIHYDROXYPYRIMIDINE
  • 2,4(1H,3H)-Pyrimidinedione, 5-chloro- (9CI)
  • 5-Chloro-2,4(1H,3H)-pyrimidinedione
  • NSC 28172
  • 5-CHLOROURACIL CRYSTALLINE
  • 5-Chlorouracil,98%
  • Fluorouracil BP Impurity E
  • 5-Chlorouracil &gt
  • 5-Chlorouracil USP/EP/BP
  • 5-Chlorouracil (Fluorouracil Impurity)
  • 4(1H,3H)-Pyrimidinedione,5-chloro-
  • Fluorouracil EP Impurity E (5-Chlorouracil)
  • 5-ChlorouracilQ: What is 5-Chlorouracil Q: What is the CAS Number of 5-Chlorouracil Q: What is the storage condition of 5-Chlorouracil Q: What are the applications of 5-Chlorouracil
  • Fluorouracil Related Compound E (5-Chloropyrimidine-2,4(1H,3H)-dione) (1279054)
  • Fluorouracil USP Related Compound E
  • 5-chloro-2,4-dioxopyrimidine
  • Fluorouracil Related Compound E (5-Chloropyrimidine-2,4(1H,3H)-dione)
  • Fluorouracil EP Impurity E (Fluorouracil USP Related Compound E)
  • 5-Chloropyrimidine-2,4(1H,3H)-dione (5-Chlorouracil)
  • 1820-81-1
  • 156-2-19
  • C4H3ClN2O2
  • Building Blocks
  • Pyrimidines
  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Pyrimidine series
  • Heterocyclic Compounds
  • Biochemistry
  • Nucleobases and their analogs
  • Nucleosides, Nucleotides & Related Reagents
  • Nucleic acids
  • Bases & Related Reagents
  • Heterocycles
  • Nucleotides
  • PYRIMIDINE