6-Chloro-3-methyluracil
- Product Name
- 6-Chloro-3-methyluracil
- CAS No.
- 4318-56-3
- Chemical Name
- 6-Chloro-3-methyluracil
- Synonyms
- 6-chloro-3-methylpyrimidine-2,4(1H,3H)-dione;3-METHYL-6-CHLOROURACIL;6-chloro-2-hydroxy-3-MethylpyriMidin-4(3H)-one;Chloro-3-Methylura;6-Chloro-3-Methyuracil;3-METHYL-6-CHLOROURACI;Alogliptin Impurity 86;6-Chloro-3-methyluraci;6-CHLORO-3-METHYLURACIL;6-Chloro-3-dimethyl uracil
- CBNumber
- CB9283127
- Molecular Formula
- C5H5ClN2O2
- Formula Weight
- 160.56
- MOL File
- 4318-56-3.mol
6-Chloro-3-methyluracil Property
- Melting point:
- 278-280°C (dec.)
- Density
- 0,896 gr/cm
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 7.16±0.40(Predicted)
- color
- White to Almost white
- BRN
- 511456
- InChI
- InChI=1S/C5H5ClN2O2/c1-8-4(9)2-3(6)7-5(8)10/h2H,1H3,(H,7,10)
- InChIKey
- SGLXGFAZAARYJY-UHFFFAOYSA-N
- SMILES
- C1(=O)NC(Cl)=CC(=O)N1C
- CAS DataBase Reference
- 4318-56-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 713465
- Product name
- 6-Chloro-3-methyluracil
- Purity
- ≥98%
- Packaging
- 100g
- Price
- $300
- Updated
- 2025/07/31
- Product number
- C2300
- Product name
- 6-Chloro-3-methyluracil
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $36
- Updated
- 2025/07/31
- Product number
- C2300
- Product name
- 6-Chloro-3-methyluracil
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $111
- Updated
- 2025/07/31
- Product number
- C369665
- Product name
- 6-Chloro-3-methyluracil
- Packaging
- 10g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 162126
- Product name
- 6-Chloro-3-methyluracil
- Packaging
- 10g
- Price
- $403
- Updated
- 2021/12/16
6-Chloro-3-methyluracil Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
6-Chloro-3-methyluracil have been used in the synthesis of antibacterial agents as inhibitors of Helicobacter pylori glutamate racemase.
Definition
ChEBI: 6-Chloro-3-methyluracil is a member of pyrimidines and an organohalogen compound.
Synthesis
2565-47-1
4318-56-3
General procedure for the synthesis of 3-methyl-6-chlorouracil from 1-methylpyrimidine-2,4,6(1H,3H,5H)-trione: Water (2.7 mL) was added slowly and dropwise at 0 °C to a 1-methylpyrimidine-2,4,6(1H,3H,5H)-trione (14.2 g, 100 mmol) formed with phosphorus oxychloride (POCl3, 95 mL) in a in a suspension. Subsequently, the reaction mixture was warmed to 80 °C and maintained for 5 hours. Upon completion of the reaction, the resulting brown solution was cooled and the POCl3 was evaporated under reduced pressure.The residue was treated with methanol (MeOH) and the resulting solid was purified by recrystallization from ethanol to give 11.5 g of 3-methyl-6-chlorouracil (yield: 71.6%). The melting point of the product was 279-282 °C (decomposition), which is consistent with literature values (280-282 °C).1H NMR (400 MHz, DMSO-d6) δ 3.10 (s, 3H), 5.90 (s, 1H), 12.4 (br s, 1H).
References
[1] Journal of Heterocyclic Chemistry, 2014, vol. 51, # 3, p. 594 - 597
[2] Tetrahedron Asymmetry, 1997, vol. 8, # 14, p. 2319 - 2323
[3] Patent: WO2009/73210, 2009, A1. Location in patent: Page/Page column 76
[4] Patent: WO2006/133261, 2006, A2. Location in patent: Page/Page column 30
[5] Patent: WO2007/143705, 2007, A2. Location in patent: Page/Page column 23
6-Chloro-3-methyluracil Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Chloro-3-methyluracil manufacturers
- Product
- 6-Chloro-3-methyluracil 4318-56-3
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- 99
- Supply Ability
- 1000
- Release date
- 2025-08-11
- Product
- 6-Chloro-3-methyluracil 4318-56-3
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2025-06-27
- Product
- 6-Chloro-3-methyluracil 4318-56-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2025-04-09