ChemicalBook > CAS DataBase List > Dihydroergotoxine mesylate

Dihydroergotoxine mesylate

Product Name: Dihydroergotoxine mesylate
CAS No.: 8067-24-1
Chemical Name: Dihydroergotoxine mesylate
Synonyms: ERGOLOID MESYLATES;hydergine;circanol;Epos;ergoloid mesylate;cck179;Decril;Trigot;Inorter;Dacoren
CBNumber: CB6226235
Molecular Formula: C20H29N3O5S
Formula Weight: 423.53
MOL File: 8067-24-1.mol

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Dihydroergotoxine mesylate Property

storage temp.: Store at RT
solubility: DMSO: Slightly Soluble; Methanol: 1 mg/ml
form: Solid
color: White to off-white
InChI: InChI=1/C19H25N3O2.CH4O3S/c1-11(10-23)21-19(24)13-6-15-14-4-3-5-16-18(14)12(8-20-16)7-17(15)22(2)9-13;1-5(2,3)4/h3-5,8,11,13,15,17,20,23H,6-7,9-10H2,1-2H3,(H,21,24);1H3,(H,2,3,4)/t11-,13+,15+,17+;/s3
InChIKey: ONYMVHQTXOEAOV-TZWRWDCZNA-N
SMILES: C12C3=CC=CC=1[C@@]1([H])C[C@H](CN(C)[C@]1([H])CC2=CN3)C(=O)N[C@@H](C)CO.S(=O)(=O)(O)C |&1:6,9,13,22,r|

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Safety

Hazard Codes: T
Risk Statements: 60
Safety Statements: 53-36/37/39-45
RIDADR: 1544
RTECS: KE8800000
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 3003490000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C2510000
Product name: Codergocrine mesilate
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 60 mg
Price: $118
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1239504
Product name: Ergoloid mesylate salt
Packaging: 300mg
Price: $376
Updated: 2025/07/31

Sigma-Aldrich

Product number: C2510000
Product name: Codergocrine mesilate
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: c2510000
Price: $220
Updated: 2024/03/01

Cayman Chemical

Product number: 24095
Product name: Ergoloid (mesylates)
Purity: ≥95%
Packaging: 25mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 24095
Product name: Ergoloid (mesylates)
Purity: ≥95%
Packaging: 50mg
Price: $65
Updated: 2024/03/01

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Dihydroergotoxine mesylate Chemical Properties,Usage,Production

Description

Ergoloid, also known as dihydroergotoxine mesylate, is a mixture of the ergot alkaloids dihydroergocornine, dihydroergocrystine, and dihydroergocryptine. It blocks reflex vasodilation and vasoconstriction induced by norepinephrine in dogs when injected into the kidney at a dose of 0.15 mg. Ergoloid blocks norepinephrine-induced cAMP production in rat brain cortical homogenates ex vivo in a dose-dependent manner. It also acts as an erectogenic agent in rats. Formulations containing ergoloid have been used in the treatment of migraine headaches and vascular dementias.

Uses

Cognition adjuvant. Dihydroergotoxine mesylate binds with high affinity to GABAA receptor Cl- channel. Interacts with central dopaminergic, serotonergic and adrenergic (a1) receptors. Exhibits antirproliferative activity in vitro. Displays cognition-enhancing, anticonvulsant and sedative activity in vivo. Dihydroergotoxine mesylate is a substrate of GABA Receptor.

Definition

ChEBI: Dihydroergotoxine mesylate is a mixture of hydrogenated ergot alkaloids consisting of the methanesulfonic acid salts of dihydroergocornine (R = CHMe2), dihydroergocristine (R = CH2Ph), and alpha- and beta-dihydroer ocryptine (R = CH2CHMe2 and CH(Me)Et, respectively). It is used for the symptomatic treatment of mild to moderate dementia in the elderly, although its value is not established.

brand name

Alkergot (Sandoz); Circanol(3M Pharmaceuticals); Deapril (Bristol-Myers Squibb);Gerimal (Watson); Hydergine (Novartis).

Biological Activity

Dihydroergotoxine mesylate is a complex of closely related alkaloid salts. Binds with high affinity to the GABAA receptor Cl- channel, producing an allosteric interaction with the benzodiazepine site. Also interacts with central dopaminergic, serotonergic and adrenergic (α1) receptors. Displays antiproliferative activity in vitro (IC50 = 18 - 38 μM in prostate cancer cells) and exhibits cognition-enhancing, anticonvulsant and sedative activity in vivo.

Pharmacology

The metabolic effects of ergoloid mesylates (Hydergine) may include enhancement of noradrenergic, dopaminergic and serotoninergic neurotransmission (Weil,1988) and reduction of free radicals. Schneider and Olin (1994) reviewed 151 reports on the use of Hydergine in senile dementia, but only 47 of these trials (31%) met strict criteria for meta-analysis. ACochrane review (Olin et al., 2001) confirmed that patients with VaD appeared to benefit more than patients with AD in terms of cognition,clinical global ratings and combined measures. However, compared with placebo, efficacy was very modest. Thus, there are no grounds to recommend its use.

References

[1] S MATSUSHITA. Pharmacological studies on reflex renal vasodilatation.[J]. Tohoku Journal of Experimental Medicine, 1969, 99 1: 51-57. DOI: 10.1620/tjem.99.51
[2] R. MARKSTEIN H. W. The effect of dihydroergotoxin, phentolamine and pindolol on catecholamine-stimulated adenylcyclase in rat cerebral cortex[J]. FEBS Letters, 1975, 55 1: Pages 275-277. DOI: 10.1016/0014-5793(75)81010-6
[3] MILOVAN RADOSAVLJEVIC. Influence of Dihydroergotoxine, Bromocriptine, and Ergotamine on Penile Erection in Wistar Rats[J]. Journal of andrology, 2013, 33 5: 866-871. DOI: 10.2164/jandrol.111.015461

Dihydroergotoxine mesylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Dihydroergotoxine mesylate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Dihydroergotoxine mesylate 8067-24-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KG
Release date: 2024-08-07

Henan Fengda Chemical Co., Ltd

Product: Dihydroergotoxine mesylate 8067-24-1
Price: US $8.00-1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-03

Career Henan Chemical Co

Product: Dihydroergotoxine mesylate 8067-24-1
Price: US $106.00/G
Min. Order: 1G
Purity: 98%
Supply Ability: 100kg
Release date: 2018-07-24

8067-24-1, Dihydroergotoxine mesylateRelated Search:

Levofloxacin Methylate Methanesulfonic acid Pazufloxacin mesilate Imatinib Pefloxacin mesylate DIHYDROERGOTAMINE MESYLATE alpha-methyl-1H-indole-3-ethylamine monomethanesulphonate α-Ethyltryptamine 3-PHENYLPIPERIDINE 3-(Aminomethyl)-1-methylpiperidine NIPECOTAMIDE 1H-INDOLE-4-ETHANAMINE CO-DERGOCRINE MESILATE 2-Ethoxy-3-pyridineboronic acid Dihydroergotoxine RAC PIPERIDINE-3-CARBOXYLIC ACID (2-HYDROXYETHYL)-AMIDE N-ethylpiperidine-3-carboxamide R)-3-PHENYL PIPERIDINE

cck179

circanol

co-dergocrinemesylate

dihydroergotoxinemesilate

dihydroergotoxinemethanesulfonate

dihydroergotoxinemethanesulphonate

dihydroergotoxinemonomethanesulfonate(salt)

dihydroergotoxinmesylate

dihydroergotoxinmethanesulfonate

dihydro-ergotoxinmethanesulfonate

dihydro-ergotoxinmonomethanesulfonate(salt)

hydergin

hydergine

ischelium

redergin

ERGOLOID MESYLATES

DIHYDROERGOTOXINE MESYLATE

DIHYDROERGOTOXINE MONOMETHANESULFONATE

Dihydroxy Ergotoxin mesylate

dihydroergotoxine monomethanesulphonate

ergoloid mesylate

Ergoloid Mesylates (Dihydroergotoxine Mesilate)

Dihydroergotoxin mesylate salt

Ergoloid mesylate salt

Epos

Inorter

Ergoloid Mesylates (300 mg)

ERGOLOIDMESYLATES,USP

Co-dercrine mesylate

Codergine mesylate

Codergocrine methanesulfonate

Coristin

Dacoren

Deapril ST

Decril

Dulcion

Ergodesit

Ergohydrin

Ergoplus

Ergotoxine, dihydro-, monomethanesulfonate (salt)

Hydergine (8CI)

Novofluen

Perenan

Progeril

Sponsin

Trigot

DihydroergotoxinMesilat

Co-dergocrine

Dihydroergotoxine Mesilate RS

Codergocrine mesilate CRS

Dihydro-ergotoxine Methanesulfonate (1.0mg/ml in DMSO)

Dihydroergotoxine mesylate 8067-24-1

Ergoloid Mesylates (1239504)

amixtureof: —(6aR,9R,10aR)-N-[(2R,5S,10aS,10bS)-10b-hydroxy-2,5-bis(1-methylethyl)-3,6-dioxooctahydro-8h-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl]-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamidemethanesulfonate(dihydroergocorninemesilate)

Cocaine Hydrochloride Impurity 2(Cocaine Hydrochloride EP Impurity B )(α-Truxilline)

Dihydroergotoxine mesylate, 10 mM in DMSO

Codergocrine mesilate for peak indentification CRS

8067-24-1