NIPECOTAMIDE

Product Name: NIPECOTAMIDE
CAS No.: 4138-26-5
Chemical Name: NIPECOTAMIDE
Synonyms: NIPECOTAMIDE;Nipecotamide>Nipecotamide,95%;Nipecotamide,97%;TIMTEC-BB SBB004239;nipecotic acid amide;NipecotaMide, 95% 5GR;HEXAHYDRONICOTINAMIDE;3-Carbamoylpiperidine;Butafenacil Impurity 5
CBNumber: CB9345421
Molecular Formula: C6H12N2O
Formula Weight: 128.17
MOL File: 4138-26-5.mol

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NIPECOTAMIDE Property

Melting point:: 103-106 °C(lit.)
Boiling point:: 237.61°C (rough estimate)
Density: 1.0754 (rough estimate)
refractive index: 1.4880 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 16.50±0.20(Predicted)
form: Crystalline Powder
color: Yellow
InChI: InChI=1S/C6H12N2O/c7-6(9)5-2-1-3-8-4-5/h5,8H,1-4H2,(H2,7,9)
InChIKey: BVOCPVIXARZNQN-UHFFFAOYSA-N
SMILES: N1CCCC(C(N)=O)C1
CAS DataBase Reference: 4138-26-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N8105
Product name: Nipecotamide
Purity: 95%
Packaging: 10g
Price: $94.6
Updated: 2022/05/15

TCI Chemical

Product number: N0097
Product name: Nipecotamide
Purity: >98.0%(T)
Packaging: 5g
Price: $51
Updated: 2025/07/31

TCI Chemical

Product number: N0097
Product name: Nipecotamide
Purity: >98.0%(T)
Packaging: 25g
Price: $133
Updated: 2025/07/31

TRC

Product number: N478405
Product name: Nipecotamide
Packaging: 5g
Price: $60
Updated: 2021/12/16

Usbiological

Product number: 460778
Product name: Nipecotamide
Packaging: 1g
Price: $305
Updated: 2021/12/16

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NIPECOTAMIDE Chemical Properties,Usage,Production

Chemical Properties

YELLOW CRYSTALLINE POWDER

Uses

Reactant for synthesis of:• ;DPP-4 inhibitors1• ;IKKβ inhibitors2• ;Spiroimidazolidinone NPC1L1 inhibitors3• ;Sulfamides4• ;Phosphodiesterase 5 inhibtors5• ;Anti-HIV agents6

Uses

Nipecotamide, is a budiling blcok used in the sythnesis of various compounds, such as DPP-4 inhibitors, IKKβ inhibitors, piroimidazolidinone NPC1L1 inhibitors, and Anti-HIV agents.

Definition

ChEBI: The amide resulting from the formal condensation of nipecotic acid with ammonia.

Synthesis

98-92-0

4138-26-5

122.12 g (1.00 mol) of nicotinamide was dissolved in 500 mL of 2-propanol. To this solution was added 14.4 g of 10% palladium-carbon catalyst, followed by stirring the reaction for 4 hours at 75 °C under 0.5 MPa hydrogen pressure. Upon completion of the reaction, the palladium-carbon catalyst was removed by filtration and the filter cake was washed with 100 mL of 2-propanol. The filtrate and washings were combined and concentrated to give 126.08 g of racemic 3-piperidinecarboxamide white crystals in 98.4% yield. The structure of the product was confirmed by NMR characterization.

References

[1] Patent: US2012/123128, 2012, A1. Location in patent: Page/Page column 3
[2] Synlett, 2006, # 9, p. 1440 - 1442
[3] Chemistry - A European Journal, 2009, vol. 15, # 28, p. 6953 - 6963
[4] Synlett, 2008, # 8, p. 1125 - 1128
[5] Journal of the American Chemical Society, 1949, vol. 71, p. 1680

NIPECOTAMIDE Preparation Products And Raw materials

Raw materials

Nicotinamide Ruthenium

Preparation Products

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NIPECOTAMIDE Suppliers

Americas 1 Belgium 1 Canada 2 China 156 Czech Republic 1 Europe 1 Germany 3 India 5 Japan 4 Singapore 1 South Korea 1 Switzerland 2 Ukraine 1 United Kingdom 11 United States 29 Global 219

Chengdu up7 Pharmaceutical Technology Co., Ltd

Tel: 028-18109011186 18109011186
Email: 1593991055@qq.com
Country: China
ProdList: 38
Advantage: 58

Shanghai Hobor Chemical Co., Ltd

Tel: 021-57790084; 13918007836
Fax: 021-51685238
Email: sales@hoborchem.com
Country: China
ProdList: 392
Advantage: 60

Hubei zhonglong Kangsheng Fine Chemical Co., Ltd

Tel: 027-027-83850178 18162590268
Fax: 027-83850178
Email: 1984393783@qq.com
Country: China
ProdList: 990
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3572
Advantage: 66

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

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View Lastest Price from NIPECOTAMIDE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: NIPECOTAMIDE 4138-26-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-03-19

Shaanxi Dideu Medichem Co. Ltd

Product: NIPECOTAMIDE 4138-26-5
Price: US $1.00-25.00/KG
Min. Order: 1KG
Purity: 99%+
Supply Ability: 1076KG
Release date: 2024-05-17

Career Henan Chemical Co

Product: NIPECOTAMIDE 4138-26-5
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 533
Release date: 2019-09-01

4138-26-5, NIPECOTAMIDERelated Search:

Dihydroergotoxine mesylate Umespirone (2S)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide) NIPECOTAMIDE Cabergoline Rispenzepine dihydroergocristine N,N-DIETHYLNIPECOTAMIDE DIHYDROERGOCRISTINE MESYLATE Epicriptine amesergide DIHYDROERGOTAMINE TARTRATE 1-methylpiperidine-3-carboxamide (HCl) (R)-1-N-BOC-PIPECOLAMIDE LONAFARNIB Pipecolamide Mepivacaine hydrochloride Dihydroergotoxine

HEXAHYDRONICOTINAMIDE

NIPECOTAMIDE

PIPERIDINE-3-CARBOXAMIDE

3-PIPERIDINECARBOXAMIDE

TIMTEC-BB SBB004239

Nipecotamide,97%

nipecotic acid amide

3-Piperdine carboxamide

Nipecotamide,95%

piperidine-3-carboxylic acid amide

NipecotaMide, 95% 5GR

3-Carbamoylpiperidine

Nipecotamide&gt

Butafenacil Impurity 5

Piperidine-3-carboxamide - [P12323]

4138-26-5

Building Blocks

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C5 to C7

Building Blocks

Chemical Synthesis

Heterocyclic Building Blocks

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Piperidines

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts