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NIPECOTAMIDE

Product Name
NIPECOTAMIDE
CAS No.
4138-26-5
Chemical Name
NIPECOTAMIDE
Synonyms
NIPECOTAMIDE;Nipecotamide>Nipecotamide,95%;Nipecotamide,97%;TIMTEC-BB SBB004239;nipecotic acid amide;NipecotaMide, 95% 5GR;HEXAHYDRONICOTINAMIDE;3-Carbamoylpiperidine;Butafenacil Impurity 5
CBNumber
CB9345421
Molecular Formula
C6H12N2O
Formula Weight
128.17
MOL File
4138-26-5.mol
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NIPECOTAMIDE Property

Melting point:
103-106 °C(lit.)
Boiling point:
237.61°C (rough estimate)
Density 
1.0754 (rough estimate)
refractive index 
1.4880 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
16.50±0.20(Predicted)
form 
Crystalline Powder
color 
Yellow
InChI
InChI=1S/C6H12N2O/c7-6(9)5-2-1-3-8-4-5/h5,8H,1-4H2,(H2,7,9)
InChIKey
BVOCPVIXARZNQN-UHFFFAOYSA-N
SMILES
N1CCCC(C(N)=O)C1
CAS DataBase Reference
4138-26-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39
WGK Germany 
3
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N8105
Product name
Nipecotamide
Purity
95%
Packaging
10g
Price
$94.6
Updated
2022/05/15
TCI Chemical
Product number
N0097
Product name
Nipecotamide
Purity
>98.0%(T)
Packaging
5g
Price
$51
Updated
2025/07/31
TCI Chemical
Product number
N0097
Product name
Nipecotamide
Purity
>98.0%(T)
Packaging
25g
Price
$133
Updated
2025/07/31
Usbiological
Product number
460778
Product name
Nipecotamide
Packaging
1g
Price
$305
Updated
2021/12/16
Usbiological
Product number
284950
Product name
Nipecotamide
Packaging
10g
Price
$382
Updated
2021/12/16
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NIPECOTAMIDE Chemical Properties,Usage,Production

Chemical Properties

YELLOW CRYSTALLINE POWDER

Uses

Reactant for synthesis of:• ;DPP-4 inhibitors1• ;IKKβ inhibitors2• ;Spiroimidazolidinone NPC1L1 inhibitors3• ;Sulfamides4• ;Phosphodiesterase 5 inhibtors5• ;Anti-HIV agents6

Uses

Nipecotamide, is a budiling blcok used in the sythnesis of various compounds, such as DPP-4 inhibitors, IKKβ inhibitors, piroimidazolidinone NPC1L1 inhibitors, and Anti-HIV agents.

Definition

ChEBI: The amide resulting from the formal condensation of nipecotic acid with ammonia.

Synthesis

98-92-0

4138-26-5

122.12 g (1.00 mol) of nicotinamide was dissolved in 500 mL of 2-propanol. To this solution was added 14.4 g of 10% palladium-carbon catalyst, followed by stirring the reaction for 4 hours at 75 °C under 0.5 MPa hydrogen pressure. Upon completion of the reaction, the palladium-carbon catalyst was removed by filtration and the filter cake was washed with 100 mL of 2-propanol. The filtrate and washings were combined and concentrated to give 126.08 g of racemic 3-piperidinecarboxamide white crystals in 98.4% yield. The structure of the product was confirmed by NMR characterization.

References

[1] Patent: US2012/123128, 2012, A1. Location in patent: Page/Page column 3
[2] Synlett, 2006, # 9, p. 1440 - 1442
[3] Chemistry - A European Journal, 2009, vol. 15, # 28, p. 6953 - 6963
[4] Synlett, 2008, # 8, p. 1125 - 1128
[5] Journal of the American Chemical Society, 1949, vol. 71, p. 1680

NIPECOTAMIDE Preparation Products And Raw materials

Raw materials

Nicotinamide Ruthenium

Preparation Products

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View Lastest Price from NIPECOTAMIDE manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
NIPECOTAMIDE 4138-26-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-03-19
Shaanxi Dideu Medichem Co. Ltd
Product
NIPECOTAMIDE 4138-26-5
Price
US $1.00-25.00/KG
Min. Order
1KG
Purity
99%+
Supply Ability
1076KG
Release date
2024-05-17
Career Henan Chemical Co
Product
NIPECOTAMIDE 4138-26-5
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
JD 533
Release date
2019-09-01

4138-26-5, NIPECOTAMIDERelated Search:

Dihydroergotoxine mesylate Umespirone (2S)-N-(2,6-Dimethylphenyl)-2-piperidinecarboxamide) NIPECOTAMIDE Cabergoline Rispenzepine dihydroergocristine N,N-DIETHYLNIPECOTAMIDE DIHYDROERGOCRISTINE MESYLATE Epicriptine amesergide DIHYDROERGOTAMINE TARTRATE 1-methylpiperidine-3-carboxamide (HCl) (R)-1-N-BOC-PIPECOLAMIDE LONAFARNIB Pipecolamide Mepivacaine hydrochloride Dihydroergotoxine

  • HEXAHYDRONICOTINAMIDE
  • NIPECOTAMIDE
  • PIPERIDINE-3-CARBOXAMIDE
  • 3-PIPERIDINECARBOXAMIDE
  • TIMTEC-BB SBB004239
  • Nipecotamide,97%
  • nipecotic acid amide
  • 3-Piperdine carboxamide
  • Nipecotamide,95%
  • piperidine-3-carboxylic acid amide
  • NipecotaMide, 95% 5GR
  • 3-Carbamoylpiperidine
  • Nipecotamide&gt
  • Butafenacil Impurity 5
  • Piperidine-3-carboxamide - [P12323]
  • 4138-26-5
  • Building Blocks
  • Heterocyclic Building Blocks
  • Piperidines
  • C5 to C7
  • Building Blocks
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • Building Blocks
  • Heterocyclic Building Blocks
  • Piperidines
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts