PROCYCLIDINE HYDROCHLORIDE
- Product Name
- PROCYCLIDINE HYDROCHLORIDE
- CAS No.
- 1508-76-5
- Chemical Name
- PROCYCLIDINE HYDROCHLORIDE
- Synonyms
- kemadrin;PROCYCLIDINE HCL;D00782;Osnervan;Arpicolin;Kemadrin (tn);kemadrinhydrochloride;PROCYCLIDINE HYDROCHLORIDE;(±)-Procyclidine hydrochlorid;Procyclidine hydrochloride (usp)
- CBNumber
- CB6229812
- Molecular Formula
- C19H30ClNO
- Formula Weight
- 323.9
- MOL File
- 1508-76-5.mol
PROCYCLIDINE HYDROCHLORIDE Property
- Melting point:
- 159-164 °C
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22
- Safety Statements
- 36
- WGK Germany
- 3
- RTECS
- UY1926000
- HS Code
- 2933997500
- Toxicity
- mouse,LD50,intravenous,14mg/kg (14mg/kg),BEHAVIORAL: TREMORLUNGS, THORAX, OR RESPIRATION: DYSPNEABEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,British Journal of Pharmacology and Chemotherapy. Vol. 10, Pg. 383, 1955.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403Store in a well-ventilated place.
N-Bromosuccinimide Price
- Product number
- P3794
- Product name
- Procyclidine hydrochloride
- Packaging
- 1g
- Price
- $159
- Updated
- 2024/03/01
- Product number
- 1567004
- Product name
- Procyclidine hydrochloride
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $174.4
- Updated
- 2024/03/01
- Product number
- P3794
- Product name
- Procyclidine hydrochloride
- Packaging
- 5g
- Price
- $629
- Updated
- 2024/03/01
- Product number
- 019991
- Product name
- Procyclidine Hydrochloride
- Packaging
- 10mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- P755840
- Product name
- Procyclidine hydrochloride
- Packaging
- 5g
- Price
- $480
- Updated
- 2021/12/16
PROCYCLIDINE HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
An anticholinergic drug used in the treatment parkinson’s disease. It is also used to treat patients suffering from drug-induced parkinsonism, akathisia and acute dystonia.
brand name
Kemadrin (Monarch).
General Description
Procyclidine hydrochloride,α-cyclohexyl-α-phenyl-1-pyrrolidinepropanolhydrochloride (Kemadrin), was introduced in 1956. Althoughit is an effective peripheral anticholinergic and, indeed, hasbeen used for peripheral effects similar to its methochloride(i.e., tricyclamol chloride), its clinical usefulness lies inits ability to relieve voluntary muscle spasticity by its centralaction. Therefore, it has been used with success in thetreatment of Parkinson syndrome. It is said to be as effectiveas trihexyphenidyl and is used to reduce muscle rigidityin postencephalitic, arteriosclerotic, and idiopathic types ofthe disease. Its effect on tremor is not predictable and probablyshould be supplemented by combination with othersimilar drugs.
The toxicity of the drug is low, but when the dosageof the drug is high, side effects are noticeable. At therapeuticdosage levels, dry mouth is the most common sideeffect. The same care should be exercised with this drugas with all other anticholinergics when it is administeredto patients with glaucoma, tachycardia, or prostatichypertrophy.
Biochem/physiol Actions
Procyclidine is a synthetic anti-cholinergic agent and atropine-like antispasmodic. It exhibits therapeutic effects against Parkinson′s disease and schizophrenia. Procyclidine acts as a muscarinic receptor antagonist. It also affects N-methyl-D-aspartate (NMDA) glutamine and nicotinic acetylcholine receptors to a lower extent.
Clinical Use
Control of extrapyramidal symptoms
Acute dystonias
Metabolism
When given orally about one fifth of the dose is known to be metabolised in the liver, principally by cytochrome P450 and then conjugated with glucuronic acid. Metabolites have been found in the urine.
PROCYCLIDINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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