Tert-Butyl 4-(bromomethyl)phenylcarbamate

Product Name: Tert-Butyl 4-(bromomethyl)phenylcarbamate
CAS No.: 239074-27-2
Chemical Name: Tert-Butyl 4-(bromomethyl)phenylcarbamate
Synonyms: tert-Butyl (4-(bromomethyl);N-Boc-4-(broMoMethyl)aniline;4-(Bromomethyl)aniline, N-BOC protected;TERT-BUTYL 4-(BROMOMETHYL)PHENYLCARBAMATE;tert-butyl N-[4-(bromomethyl)phenyl]carbamate;4-(1,1-dimethylethoxycarbonylamino)benzylbromide;(4-Bromomethyl)phenyl]carbamic acid tert-butyl ester;Carbamic acid, [4-(bromomethyl)phenyl]-, 1,1-dimethylethyl e...;Carbamic acid, [4-(bromomethyl)phenyl]-, 1,1-dimethylethyl ester;Carbamic acid, N-[4-(bromomethyl)phenyl]-, 1,1-dimethylethyl ester
CBNumber: CB62459172
Molecular Formula: C12H16BrNO2
Formula Weight: 286.16
MOL File: 239074-27-2.mol

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Tert-Butyl 4-(bromomethyl)phenylcarbamate Property

Boiling point:: 309.7±25.0 °C(Predicted)
Density: 1.376±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 13.49±0.70(Predicted)

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Safety

HS Code: 2921490090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

TRC

Product number: B201058
Product name: N-Boc-4-(Bromomethyl)aniline
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: J55812
Product name: tert-Butyl4-(bromomethyl)phenylcarbamate
Packaging: 1g
Price: $115
Updated: 2021/12/16

AK Scientific

Product number: 7355AJ
Product name: tert-Butyl4-(bromomethyl)phenylcarbamate
Packaging: 1g
Price: $151
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0373079
Product name: TERT-BUTYL-4-(BROMOMETHYL)PHENYLCARBAMATE
Purity: 95.00%
Packaging: 5MG
Price: $498.97
Updated: 2021/12/16

Ambeed

Product number: A217730
Product name: tert-Butyl(4-(bromomethyl)phenyl)carbamate
Purity: 97%
Packaging: 100mg
Price: $36
Updated: 2021/12/16

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Tert-Butyl 4-(bromomethyl)phenylcarbamate Chemical Properties,Usage,Production

Synthesis

To a 1 L round bottom flask was added (4-hydroxymethyl-phenyl)-carbamic acid tert-butyl ester (22.3 g, 0.10 mol) obtained from Examples 2pp through 2ooo, Step 1, dichloromethane (400 mL) and triphenylphospine (31.5 g, 0.12 mol). Upon cooling to 0 °C, N-bromosuccinimide (19.6 g, 0.11 mmol) was added in small portions, and the reaction was allowed to warm to room temperature and stirred under nitrogen for 1 h. The mixture was transferred into a large flask, and hexanes were added until the solution became turbid. The solution was eluted through a plug of silica (300 g) with 1:9 ethyl acetate: hexanes and concentrated to yield Tert-Butyl 4-(bromomethyl)phenylcarbamate (12.8 g, 0.057 mol, 57 percent) as a white solid.

References

[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 23, p. 9354 - 9370
[2] Patent: WO2006/31806, 2006, A2. Location in patent: Page/Page column 99
[3] Journal of Medicinal Chemistry, 1989, vol. 32, # 4, p. 811 - 826

Tert-Butyl 4-(bromomethyl)phenylcarbamate Preparation Products And Raw materials

Raw materials

Preparation Products

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Tert-Butyl 4-(bromomethyl)phenylcarbamate Suppliers

China 85 India 1 United States 4 Global 90

Energy Chemical

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View Lastest Price from Tert-Butyl 4-(bromomethyl)phenylcarbamate manufacturers

Shanghai Rlavie Technology Co ltd

Product: N-Boc-4-(bromomethyl)aniline 239074-27-2
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: 100kgs/month
Release date: 2021-11-20

Honest Joy Holdings Limited

Product: tert-Butyl 4-(bromomethyl)phenylcarbamate 239074-27-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.7%
Supply Ability: 100 tons
Release date: 2022-01-26

Career Henan Chemical Co

Product: TERT-BUTYL 4-(BROMOMETHYL)PHENYLCARBAMATE 239074-27-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500kg
Release date: 2019-12-26

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239074-27-2