(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione

ChemicalBook > CAS DataBase List > (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione

(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione

Product Name: (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione
CAS No.: 438190-29-5
Chemical Name: (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione
Synonyms: SMI-4a;CS-2669;CS-1477;SMI-4a（b）;(Z)-SMI-4a;TCS PIM-1 4a;SMI-4a, >97%;SMI-4A; SMI4A;TCS PIM-1 4a, >=98%;SMI-4a TCS PIM-1 4a
CBNumber: CB62518905
Molecular Formula: C11H6F3NO2S
Formula Weight: 273.23
MOL File: 438190-29-5.mol

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(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione Property

Density: 1.530±0.06 g/cm3(Predicted)
storage temp.: Desiccate at +4°C
solubility: DMSO: >10mg/mL
form: powder
pka: 7.38±0.20(Predicted)
color: white to beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.

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Safety

Hazard Codes: Xi
Risk Statements: 36-43
Safety Statements: 26-36/37
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0323
Product name: SMI-4a
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $118
Updated: 2022/05/15

Cayman Chemical

Product number: 11029
Product name: SMI-4a
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 11029
Product name: SMI-4a
Purity: ≥98%
Packaging: 5mg
Price: $64
Updated: 2024/03/01

Cayman Chemical

Product number: 11029
Product name: SMI-4a
Purity: ≥98%
Packaging: 10mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 11029
Product name: SMI-4a
Purity: ≥98%
Packaging: 50mg
Price: $384
Updated: 2024/03/01

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(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione Chemical Properties,Usage,Production

Description

SMI-4a (438190-29-5) is a selective, ATP-competitive inhibitor of the Pim protein kinases (IC50 = 24 and 100 nM for Pim-1 and Pim-2 respectively). Selective over a panel of ~50 other kinases.1?Induces cell cycle arrest in leukemia and prostate cancer cells.2?Blocks the growth of a wide range of myeloid and lymphoid cell lines with precursor T-cell lymphoblastic leukemia/lymphoma (pre-T-LBL/T-ALL) being highly sensitive.3?SMI-4a is a useful tool for exploring the involvement of Pim in cellular signaling.4?Cell permeable.

Uses

SMI-4a is an aldose reductase inhibitor as well as a COX-2 inhibitor, a potential agent in the inhibition and treatment of cancer and cancer cell lines.

References

1) Xia et al. (2009), Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases; J. Med. Chem., 52 74 2) Beharry et al. (2009), Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells; Mol. Cancer Ther., 8 1473 3) Lin et al. (2010), A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma; Blood, 115 824 4) Zhang et al. (2009), PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells; Cancer Biol. Ther., 8 846

(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione manufacturers

Career Henan Chemical Co

Product: (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione 438190-29-5
Price: US $5.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-09-03

438190-29-5, (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedioneRelated Search:

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(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione

TCS PIM-1 4a

SMI-4a

(Z)-5-(3-(trifluoroMethyl)benzylidene)thiazolidine-2,4-dione

2,4-Thiazolidinedione, 5-[[3-(trifluoromethyl)phenyl]methylene]-, (5Z)-

TCS PIM-1 4a, >=98%

(5E)-5-{[3-(trifluoromethyl)phenyl]methylidene}-1,3-thiazolidine-2,4-dione

(Z)-SMI-4a

TCS PIM-1 4a (SMI-4a)

SMI-4A; SMI4A

CS-2669

CS-1477

SMI 4a - Pim inhibitor 4a

SMI-4a, >97%

SMI-4A; SMI4A; SMI 4A; TCS PIM-1 4A.

SMI-4A; SMI4A;(Z)-SMI4A; (Z)-SMI 4A

5-[[3-(trifluoromethyl)phenyl]methylidene]-1,3-thiazolidine-2,4-dione

(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione USP/EP/BP

SMI-4a TCS PIM-1 4a

SMI-4a（b）

438190-29-5

Inhibitors

JAK

STAT

Inhibitor