N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine

ChemicalBook > CAS DataBase List > N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine

Product Name: N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine
CAS No.: 55778-02-4
Chemical Name: N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine
Synonyms: WZ 811;CS-567;DK7350;WZ-811; WZ811;WZ 811, >=98%;N,N'-Di-2-pyridinyl-1,4-benzenedimethanamine;N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine;1,4-Benzenedimethanamine, N1,N4-di-2-pyridinyl-;N,N'-(1,4-PHENYLENEBIS(METHYLENE))DIPYRIDIN-2-AMINE;N,N'-(1,4-phenylenebis(methylene))bis(pyridin-2-amine)
CBNumber: CB62518930
Molecular Formula: C18H18N4
Formula Weight: 290.36
MOL File: 55778-02-4.mol

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N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine Property

Melting point:: 192-194℃ (methanol )
Boiling point:: 493.2±35.0 °C(Predicted)
Density: 1.229±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO: ≥7mg/mL
form: powder
pka: 6.55±0.10(Predicted)
color: white to tan

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26
WGK Germany: 3
HS Code: 2933.39.6190

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0088
Product name: WZ 811
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $104
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0088
Product name: WZ 811
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $397
Updated: 2023/01/07

TCI Chemical

Product number: W0017
Product name: WZ 811
Packaging: 25MG
Price: $64
Updated: 2024/03/01

TCI Chemical

Product number: W0017
Product name: WZ 811
Packaging: 100MG
Price: $175
Updated: 2024/03/01

Cayman Chemical

Product number: 13639
Product name: WZ 811
Purity: ≥95%
Packaging: 1mg
Price: $19
Updated: 2024/03/01

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N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine Chemical Properties,Usage,Production

Description

The CXC chemokine receptor-4 (CXCR4) is a G protein-coupled receptor that is specific for stromal cell-derived factor-1 (SDF-1/ CXCL12). Activation of CXCR4 promotes homing of hematopoietic stem cells, chemotaxis and quiescence of lymphocytes, and growth and metastasis of certain cancer cell types. Moreover, CXCR4 on CD4⁺ T-cells is used by CXCR4-selective HIV forms as a gateway for T-cell infection. WZ811 is a potent inhibitor of binding of an SDF-1 peptide mimic to CXCR4 (EC₅₀ = 0.3 nM). It prevents SDF-1/CXCL12-mediated modulation of cAMP (EC₅₀ = 1.2 nM) in cells and blocks SDF-1-induced Matrigel™ invasion by MDA-MB-231 human breast adenocarcinoma cells (EC₅₀ = 5.2 nM). The effectiveness of WZ811 in animals remains to be elucidated.

Uses

N1,N4-di-2-Pyridinyl-1,4-benzenedimethanamine acts as an inhibitor for the chemokine receptor CXCR4.

References

[1] zhan w, liang z, zhu a, et al. discovery of small molecule cxcr4 antagonists. journal of medicinal chemistry, 2007, 50(23): 5655-5664.
[2] choi w t, duggineni s, xu y, et al. drug discovery research targeting the cxc chemokine receptor 4 (cxcr4). journal of medicinal chemistry, 2011, 55(3): 977-994.

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine manufacturers

Career Henan Chemical Co

Product: N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine 55778-02-4
Price: US $5.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-09-03

55778-02-4, N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamineRelated Search:

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N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine

WZ 811

N,N'-(1,4-PHENYLENEBIS(METHYLENE))DIPYRIDIN-2-AMINE

N,N'-Di-2-pyridinyl-1,4-benzenedimethanamine

N,N'-(1,4-phenylenebis(methylene))bis(pyridin-2-amine)

1,4-Benzenedimethanamine, N1,N4-di-2-pyridinyl-

N1,N4-di-2-pyridinyl-1,4-benzenedimethanamine WZ811

WZ 811 N,N'-Di-2-pyridinyl-1,4-benzenedimethanamine

WZ 811, >=98%

WZ-811; WZ811

CS-567

N-[[4-[(pyridin-2-ylamino)methyl]phenyl]methyl]pyridin-2-amine

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine USP/EP/BP

DK7350

Inhibitor,inhibit,WZ811,WZ 811,CXCR,WZ-811,CXC chemokine receptors

N,N'-(1,4-Phenylenebis(methylene))bis(pyridin-2-amine)

55778-02-4

Inhibitors