ChemicalBook > CAS DataBase List > (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine

(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine

Product Name
(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine
CAS No.
877399-00-3
Chemical Name
(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine
Synonyms
Crizotinib Impurity 3;5-bromo-3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-amine;Crizotinib-H;Crizotinib intermediates 1;Chiral intermediate of crizotinib;chiral intermediates of Crizotinib;(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)etho;chiral intermediates of Crizotinib Company Standards;(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin...;(R)-5-broMo-3-[1-(2,6-dichloro-3-fluoropehnyl)ethoxy]pyridin-2-aMine
CBNumber
CB62520755
Molecular Formula
C13H10BrCl2FN2O
Formula Weight
380.04
MOL File
877399-00-3.mol
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(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine Property

Melting point:
107.0 to 111.0 °C
Boiling point:
423.4±40.0 °C(Predicted)
Density 
1.643
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
powder to crystal
pka
5.55±0.10(Predicted)
color 
White to Light yellow to Light orange
InChI
InChI=1S/C13H10BrCl2FN2O/c1-6(11-8(15)2-3-9(17)12(11)16)20-10-4-7(14)5-19-13(10)18/h2-6H,1H3,(H2,18,19)/t6-/m1/s1
InChIKey
URFUZAZEKBBCEY-ZCFIWIBFSA-N
SMILES
C1(N)=NC=C(Br)C=C1O[C@@H](C1=C(Cl)C=CC(F)=C1Cl)C
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Safety

HS Code 
2933.39.9200
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B5682
Product name
(R)-5-Bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-amine
Purity
>98.0%(HPLC)
Packaging
1g
Price
$94
Updated
2024/03/01
TCI Chemical
Product number
B5682
Product name
(R)-5-Bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-amine
Purity
>98.0%(HPLC)
Packaging
5g
Price
$375
Updated
2024/03/01
TRC
Product number
B678833
Product name
(R)-5-Bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine
Packaging
500mg
Price
$55
Updated
2021/12/16
Chem-Impex
Product number
41654
Product name
(R)-5-Bromo-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-amine,98%(HPLC)
Purity
98%(HPLC)
Packaging
1G
Price
$54.88
Updated
2021/12/16
Matrix Scientific
Product number
089899
Product name
(R)-5-Bromo-3-(1-(2,6-dichloro-3-fluorophenyl)-ethoxy)pyridin-2-amine
Purity
95+%
Packaging
250mg
Price
$394
Updated
2021/12/16
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(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine Chemical Properties,Usage,Production

Chemical Properties

Pale yellow solid

Uses

(R)-5-Bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine is used in preparation of Crizotinib intermediate.

(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine Suppliers

Americas 1 China 257 Europe 1 India 5 Japan 1 United States 7 Global 272
Alfa Chemistry
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1-516-927-0118
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020-81215950 4000-868-328
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sales@alchempharmtech.com
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Aladdin Scientific
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+1-+1(833)-552-7181
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sales@aladdinsci.com
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Matrix Scientific
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View Lastest Price from (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine manufacturers

Jinan Million Pharmaceutical Co., Ltd
Product
(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine 877399-00-3
Price
US $1.00-0.50/kg
Min. Order
1kg
Purity
99%
Supply Ability
200kg
Release date
2023-12-11
hebei hongtan Biotechnology Co., Ltd
Product
(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine 877399-00-3
Price
US $30.00-20.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000kg
Release date
2024-05-17
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Crizotinib Impurity 5 877399-00-3
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
10g
Release date
2024-04-25

877399-00-3, (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amineRelated Search:

[[(2S)-2-ISOPROPYL-5-METHYLCYCLOHEXYL]OXY]ACETIC ACID Bromisoval Tribromobenzene Hydrogen bromide Pinaverium bromide 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester Crizotinib (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine

  • (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine
  • [5-Bromo-3-[(1R)-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-yl]amine
  • [5-Bromo-3-[[(R)-1-(2,6-dichloro-3-fluorophenyl)ethyl]oxy]pyridin-2-yl]amine
  • (R)-5-BroMo-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-2-ylaMine
  • (R)-5-broMo-3-[1-(2,6-dichloro-3-fluoropehnyl)ethoxy]pyridin-2-aMine
  • Crizotinib Impurity 3
  • InterMediate Ⅰof Crizotinib (R)-5-broMo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-aMine
  • 2-PyridinaMine, 5-broMo-3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-
  • Crizotinib-H
  • 5-bromo-3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-amine
  • (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy) yridine-2-amine
  • Chiral intermediate of crizotinib
  • Crizotinib intermediates 1
  • 5-bromo-3-[(1 R)-(2,6-dichloro-3-fluorophenyl) ethoxy] pyridine-2-yl] amine
  • chiral intermediates of Crizotinib
  • chiral intermediates of Crizotinib Company Standards
  • (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)etho
  • (R) -5-bromo-3 - (1- (2, 6-dichloro-3-fluorophenyl) ethoxy) pyridine-2-amine
  • (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine ISO 9001：2015 REACH
  • (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin...
  • (R)-5-bromo-3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-amine
  • 877399-00-3
  • C13H10N2OBrCl2F
  • C13H10BrCl2FN2O
  • intermediate
  • 877399-00-3