ChemicalBook > CAS DataBase List > 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one

3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one

Product Name
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
CAS No.
545445-44-1
Chemical Name
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
Synonyms
5,6-Dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-1-piperidinyl)phenyl]-2(1H)-pyridinone;in-4-yL;Apixaban-1;HSK00001094;Apixaban Impurity P;Apixaban Impurity H;RSYY(Apremilast)-36;Apixaba inretMediate B;Apixaban Intermediates;Apixaban Intermediate B
CBNumber
CB62534569
Molecular Formula
C20H25N3O3
Formula Weight
355.43
MOL File
545445-44-1.mol
More
Less

3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one Property

Melting point:
>199°C (dec.)
Boiling point:
625.0±55.0 °C(Predicted)
Density 
1.267
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
3.25±0.20(Predicted)
color 
Pale Beige
InChI
InChI=1S/C20H25N3O3/c24-19-5-1-2-10-22(19)16-6-8-17(9-7-16)23-11-3-4-18(20(23)25)21-12-14-26-15-13-21/h4,6-9H,1-3,5,10-15H2
InChIKey
SCVWQFDPLBFZAP-UHFFFAOYSA-N
SMILES
C1(=O)N(C2=CC=C(N3CCCCC3=O)C=C2)CCC=C1N1CCOCC1
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

TRC
Product number
M732788
Product name
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
Packaging
2.5g
Price
$100
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0389373
Product name
3-MORPHOLINO-1-(4-(2-OXOPIPERIDIN-1-YL)PHENYL)-5,6-DIHYDROPYRIDIN-2(1H)-ONE
Purity
95.00%
Packaging
5MG
Price
$497.22
Updated
2021/12/16
AK Scientific
Product number
W6875
Product name
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
Packaging
25g
Price
$667
Updated
2021/12/16
AK Scientific
Product number
W6875
Product name
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
Packaging
5g
Price
$201
Updated
2021/12/16
Ambeed
Product number
A893718
Product name
3-Morpholino-1-[4-(2-oxo-1-piperidyl)phenyl]-5,6-dihydropyridin-2(1H)-one
Purity
95%
Packaging
100g
Price
$228
Updated
2021/12/16
More
Less

3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one Chemical Properties,Usage,Production

Uses

3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropy can be used as an organic synthesis intermediate, mainly used in laboratory research and development and chemical production processes.

Synthesis


2 g compound C (compound Ib) and 50 ml acetonitrile were added into a three-necked flask to obtain a turbid solution. The turbid solution was stirred and cooled to 0?? C. in an ice bath. 1.75 g (6 eq) sodium hydroxide was added and stirred in the ice bath for 10 min. Then 1.9 ml of 5-chloro-valeryl chloride (2 eq) (diluted with 2 ml acetonitrile) was dropwise added while controlling the temperature to 0-5?? C. After completing the addition, the ice bath was removed and the temperature was naturally raised to 30?? C. The reaction was performed for 5 hours. After observing the absence of the starting material and the intermediate state of the reaction, the reaction solution was cooled to 0?? C. in an ice bath, and adjusted to a neutral pH with 6 N of hydrochloric acid. The reaction solution was concentrated to dryness, pulpifying for 1 hour after adding 8 ml saturated sodium bicarbonate solution, and filtered to obtain 2.29 g yellow solid. Yield: 87.5%. Purity: 95.3% (HPLC). EI-MS (m/z): 355.2. HNMR (400 MHz, DMSO, ppm) |?7.32 (d, J=8.8 Hz, 2H), 7.26 (d, J=8.8 Hz, 2H), 5.71 (t, J=4.8 Hz, 1H), 3.72-3.69 (m, 2H), 3.65-3.63 (m, 4H), 3.60-3.57 (m, 2H), 2.79-2.77 (m, 4H), 2.44-2.41 (m, 2H), 2.40-2.39 (m, 2H), 1.88-1.82 (m, 4H).

3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one Suppliers

China 404 India 26 United States 8 Global 438
Shanghai Rochi Pharmaceutical Co., Ltd.
Tel
021-38751876 15000076078
Fax
021-50275764
Email
Info@rochipharma.com
Country
China
ProdList
561
Advantage
55
ChemFuture PharmaTech (Jiangsu) Ltd
Tel
5108538618
Fax
86 510 85386988-8017
Email
suger.wang@chemfuture.com
Country
China
ProdList
822
Advantage
65
Jiangsu Vcare PharmaTech Co., Ltd.
Tel
025-58741518; 18013018875
Fax
+86-25-58744115
Email
sales@vcarepharmatech.com
Country
China
ProdList
308
Advantage
61
Shandong kelikang drug co., ltd
Tel
0531-88113608
Email
kelikangpharm@163.com
Country
China
ProdList
54
Advantage
58
Jinan Billion Pharmaceutical Technology Co., Ltd
Tel
+86-15589952515 +86-15589952515
Email
80912934@qq.com
Country
China
ProdList
56
Advantage
58
Hefei Topway Biotechnology Co.,Ltd
Tel
0551-65326752 14755135869
Fax
0086-551-65326751
Email
xxhasym@163.com
Country
China
ProdList
67
Advantage
60
Jinan Jianfeng Chemical Co., Ltd.
Tel
0531-88110457 15562555968
Email
info@pharmachemm.com
Country
China
ProdList
168
Advantage
58
Beijing Lianben Pharm-Chemicals Tech. Co.,Ltd
Tel
010-83386559 18810831598
Fax
010-83386758
Email
sales@lianben.com
Country
China
ProdList
92
Advantage
58
ZHIWE CHEMTECH CO LTD
Tel
021-20221225 13917446399
Fax
QQ:115820162
Email
sales@zhiwe.net
Country
China
ProdList
580
Advantage
61
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
zhangsn@titansci.com
Country
China
ProdList
14113
Advantage
59
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11660
Advantage
64
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
18089
Advantage
64
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8849
Advantage
52
Jinan Chenghui Shuangda biological Co., LTD
Tel
0531-58897003 15550412551
Fax
0531-58897003
Email
market@jnchsd.com
Country
China
ProdList
217
Advantage
62
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
+8613162137806 18575662672
Fax
021 51613951
Email
mzeng@3wpharm.com
Country
China
ProdList
9745
Advantage
57
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4550
Advantage
62
Shanghai Sphchem Co., Ltd.
Tel
21-21-56491756 13512199871
Fax
021-5649-1756
Email
sales@panhongchem.com
Country
China
ProdList
4000
Advantage
55
Suzhou Guide Fine Material Co.Ltd.
Tel
136-16210669 13914021065
Fax
0512-66627360
Email
sales@guide-chemicals.com
Country
China
ProdList
294
Advantage
60
Changzhou Joyous Chemical Co., Ltd.
Tel
0519-85607258
Fax
0519-85607278
Email
sales@joyouschem.com
Country
China
ProdList
296
Advantage
60
T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9900
Advantage
58
Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.
Tel
022-60116533 13207668525
Fax
022-60979672
Email
saleskc@scipharmacn.com
Country
China
ProdList
846
Advantage
58
Suzhou Carbonwell Pharma-Tech Co., Ltd
Tel
0512-0512-88981216 13776013740
Email
1320558046@qq.com
Country
China
ProdList
72
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9901
Advantage
58
Beijing Comparison Pharmaceutical Technology Co., Ltd
Tel
010-52878169 15701683040
Email
sales@bjcomparison.com
Country
China
ProdList
4687
Advantage
58
SuZhou ShiYa Biopharmaceuticals, Inc.
Tel
86(512)5235 8471 17715136450
Fax
86(512)5235 6881
Email
sales@shiyabiopharm.com
Country
China
ProdList
4171
Advantage
58
ShenZhen InnoSyn Biotech Co.,Ltd
Tel
0755-28351685 18503098468
Fax
+86-755-28466854
Email
innosyn@163.com
Country
China
ProdList
600
Advantage
55
Emei shan Hongsheng Pharmaceutical Co., LTD
Tel
0833-6186272、6186278、6170066 18990613291
Fax
0833-5590359
Email
sales@hongshengpharm.com
Country
China
ProdList
58
Advantage
60
Shanghai Witofly Chemical Co.,Ltd
Tel
Email
sales@witofly.com
Country
China
ProdList
2867
Advantage
52
Cangzhou Senary Chemical Science-tech Co., Ltd
Tel
+86-317-3563899
Fax
+86-317-3563199
Email
trade@senary.com
Country
China
ProdList
98
Advantage
56
Qingdao Kingway Pharmtech Co., Ltd.
Tel
0532-87118899
Fax
0532-84117788
Email
sales@kingwaypharm.com
Country
China
ProdList
119
Advantage
56
Jinan Mingya Medical Technology Co., Ltd.
Tel
0531-85828981
Fax
+86-531-85806006
Email
864598798@qq.com
Country
China
ProdList
588
Advantage
58
Hubei lansan Biochemical Pharmaceutical Co., Ltd.
Tel
86-714-6395877
Fax
86-714-6395835
Country
China
ProdList
26
Advantage
58
Shanghai Twisun Bio-pharm Co.,Ltd
Tel
+86-21-33282107
Fax
+86-21-37285115
Country
China
ProdList
107
Advantage
60
Ningbo Taikang Chemical Co., Ltd.
Tel
0574-87365517 18074210286
Fax
87367735
Email
sales@taikangchem.com
Country
China
ProdList
303
Advantage
58
Hubei XinyuanShun Chemical Co., Ltd.
Tel
13971561712, 13995564702, 027-50664929
Fax
027-50664927
Email
hbeixys2001@163.com
Country
China
ProdList
3123
Advantage
55
Suzhou lipin Chemical Co., Ltd
Tel
0512-0512-67509664 19888480046
Country
China
ProdList
121
Advantage
58
Taizhou Tongxin Bio-Tech Co., Ltd
Tel
0523-18601685-898 18652728585
Email
sales@allyrise.com
Country
China
ProdList
2741
Advantage
60
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41438
Advantage
60
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
17994
Advantage
56
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15185
Advantage
58
Weifang Ding Hong Pharmaceutical Technology Co., Ltd.
Tel
0536-0536-8858983 18663683121
Fax
0536-8858983
Email
dhpharm@163.com
Country
China
ProdList
39
Advantage
58
Zhengzhou TRIZ Pharmaceutical Technology Co., Ltd.
Tel
15981924004; 19943855286
Fax
0371-53392065
Email
Trizpharm@aliyun.com
Country
China
ProdList
1875
Advantage
56
Shanghai Balmxy Pharmaceutical Co., Ltd
Tel
021-24206007 13764915196
Fax
86-021-23027023
Email
sales@balmxy.com
Country
China
ProdList
6730
Advantage
55
Shouguang Jiasheng Chemical Co., Ltd.
Tel
0536-7971999 18232719690
Fax
0536-7971999
Email
sgjiasheng@hotmail.com
Country
China
ProdList
398
Advantage
58
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4951
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10287
Advantage
55
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9911
Advantage
50
Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd.
Tel
027-59420981,18702770802
Fax
027-83322098
Country
China
ProdList
1975
Advantage
50
Lihe Wuhan New Chemical Materials Co., Ltd.
Tel
027-88395709
Fax
027-88391805
Country
China
ProdList
430
Advantage
50
Shenzhen Nexconn Pharmatechs Ltd.
Tel
0755-89396905
Email
admin@nexconn.com
Country
China
ProdList
304
Advantage
55
More
Less

View Lastest Price from 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one manufacturers

Speranza Chemical Co., Ltd.
Product
3-morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one 545445-44-1
Price
US $20.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20 tons
Release date
2019-12-24
Jinan Million Pharmaceutical Co., Ltd
Product
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one 545445-44-1
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1200KG/M
Release date
2023-08-15
Hebei Dangtong Import and export Co LTD
Product
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one 545445-44-1
Price
US $100.00-60.00/kg
Min. Order
100kg
Purity
99.99%
Supply Ability
100Tons
Release date
2023-03-06

545445-44-1, 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-oneRelated Search:

1-(4-(2-methyl-6-oxopiperidin-1-yl)phenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one (4,4'‐didodecyl‐2,2'‐ bithiophene‐5,5'‐ diyl)bis(triMethylstann ane) Apixaban-13C-D3 Apixaban IMpurity(BMS-778960-01) 1,3-bis(4-bromophenyl)propan-2-one Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 1-(4-Nitrophenyl)-2-piperidinone 4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-6-[4-(5-methyl-2-oxo-1-piperidinyl)phenyl]-7-oxo-1H-pyrazolo[3,4-c]pyridine-3-carboxamide 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid Apixaban Apixaban IMpurity 6 5-chloro-N-(4-(5-morpholino-6-oxo-3,6-dihydropyridin-1(2H)-yl)phenyl)pentanamide 1-(4-Methoxyphenyl)-6-(4-iodophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester ethyl 1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate 1-(4-Hydroxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide Apixaban IMpurity 5 (BMS-591329-01)

  • 5-morpholin-4-yl-1-[4-(2-oxopiperidin-1-yl)phenyl]-2,3-dihydropyridin-6-one
  • 3-Morpholino-1-[4-(2-oxo-1-piperidyl)phenyl]-5,6-dihydropyridin-2(1H)-one
  • 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)
  • HSK00001094
  • Apixaban Impurity H
  • Apixaban Intermediates
  • Apixaban Impurity P
  • 3-Morpholin-4-yl-1-[4-(2-oxopiperidin-1-yl)phenyl]-5,6-dihydro-1H-pyridin-2-one
  • 5,6-Dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-1-piperidinyl)phenyl]-2(1H)-pyridinone
  • 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
  • Apixaba inretMediate B
  • Apixaban Intermediate B
  • Apixaban Intermediate 2
  • 3-Morpholin-4-yl-1-[4-(2-oxopiperidin-1-yl)phenyl]-5,6-dihydro-1H-pyridin-2-one (Apixaban)
  • 5,6-Dihydro-3-(morpholinyl)-1[4-(2-oxo-1- piperidinyl)phenyl]-2(1H)-pyridinone
  • Apixaban-1
  • 5,6-dihydro-3-(4-morpholine)-1-[4-(2-oxy-1-piperidyl) phenyl ]-2(1 H)-pyridone
  • -1-[4-(2-oxopiperidin-1-yL
  • in-4-yL
  • 2(1H)-Pyridinone, 5,6-dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-1-piperidinyl)phenyl]-
  • ]-5,6-dihydro-1H-pyridin-2-one
  • 5, 6-dihydro-3 -(4-morpholine)-1-[4-(2-oxo-1-piperidyl) phenyl]-2(1H) -pyridinone
  • ApixabanGF Impurity 1 ABCDEFGHJKL
  • APIXABAN CAS 503612-47-3 INTERMEDIATES
  • ，3-Morpholino-1-(4-(2-oxopiperidin-1- yl)phenyl)-5,6-dihydropyridin-2(1H)- oneethyl 7-chloro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate
  • Apixaban intermediates，5,6-Dihydro-3-(4-morpholinyl)-1-[4-(2- oxo-1-piperidinyl)phenyl]-2(1H)- pyridinone
  • Apixaban Dihydro pyridenone
  • 5,6-Dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-1-piperidinyl)phen...
  • Impurity of apixaban383
  • 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)
  • 3-(4-Morpholinyl)-1-[4-(2-oxo-1-piperidinyl)phenyl]-5,6-dihydro-2(1H)-pyridinone
  • 2(1H)-Quinolinone,3,4-dihydro-13-hydroxy-
  • RSYY(Apremilast)-36
  • 5,6-Dihydro-3-morpholino-1-(4-(2-oxopiperidin-1-phenyl)pyridin-2(1H)-one
  • 5,6-Dihydro-3-Morpholino-1-(4-(2-oxo Piperidin-1-yl) Ph)Py)2(1H) one
  • 3-Morpholino-1-[4-(2-oxo-1-piperidyl)phenyl]-5,6-dhydropyridin-2(1H)-one
  • Apixaban morpholine lactum impurity 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6- dihydropyridin-2(1H)-one
  • 3-(morpholin-4-yl)-1-[4-(2-oxopiperidin-1-yl)phenyl]-1,2,5,6-tetrahydropyridin-2-one
  • 545445-44-1