ChemicalBook > CAS DataBase List > 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one

3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one

Product Name
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
CAS No.
545445-44-1
Chemical Name
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
Synonyms
5,6-Dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-1-piperidinyl)phenyl]-2(1H)-pyridinone;in-4-yL;Apixaban-1;HSK00001094;Apixaban Inter.;Apixaban Impurity P;Apixaban Impurity H;RSYY(Apremilast)-36;Anticancer agent 209;Apixaba inretMediate B
CBNumber
CB62534569
Molecular Formula
C20H25N3O3
Formula Weight
355.43
MOL File
545445-44-1.mol
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3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one Property

Melting point:
>199°C (dec.)
Boiling point:
625.0±55.0 °C(Predicted)
Density 
1.267
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
3.25±0.20(Predicted)
color 
Pale Beige
InChI
InChI=1S/C20H25N3O3/c24-19-5-1-2-10-22(19)16-6-8-17(9-7-16)23-11-3-4-18(20(23)25)21-12-14-26-15-13-21/h4,6-9H,1-3,5,10-15H2
InChIKey
SCVWQFDPLBFZAP-UHFFFAOYSA-N
SMILES
C1(=O)N(C2=CC=C(N3CCCCC3=O)C=C2)CCC=C1N1CCOCC1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M732788
Product name
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
Packaging
2.5g
Price
$100
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0389373
Product name
3-MORPHOLINO-1-(4-(2-OXOPIPERIDIN-1-YL)PHENYL)-5,6-DIHYDROPYRIDIN-2(1H)-ONE
Purity
95.00%
Packaging
5MG
Price
$497.22
Updated
2021/12/16
AK Scientific
Product number
W6875
Product name
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
Packaging
25g
Price
$667
Updated
2021/12/16
AK Scientific
Product number
W6875
Product name
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
Packaging
5g
Price
$201
Updated
2021/12/16
Ambeed
Product number
A893718
Product name
3-Morpholino-1-[4-(2-oxo-1-piperidyl)phenyl]-5,6-dihydropyridin-2(1H)-one
Purity
95%
Packaging
100g
Price
$228
Updated
2021/12/16
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3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one Chemical Properties,Usage,Production

Uses

3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropy can be used as an organic synthesis intermediate, mainly used in laboratory research and development and chemical production processes.

Synthesis


2 g compound C (compound Ib) and 50 ml acetonitrile were added into a three-necked flask to obtain a turbid solution. The turbid solution was stirred and cooled to 0?? C. in an ice bath. 1.75 g (6 eq) sodium hydroxide was added and stirred in the ice bath for 10 min. Then 1.9 ml of 5-chloro-valeryl chloride (2 eq) (diluted with 2 ml acetonitrile) was dropwise added while controlling the temperature to 0-5?? C. After completing the addition, the ice bath was removed and the temperature was naturally raised to 30?? C. The reaction was performed for 5 hours. After observing the absence of the starting material and the intermediate state of the reaction, the reaction solution was cooled to 0?? C. in an ice bath, and adjusted to a neutral pH with 6 N of hydrochloric acid. The reaction solution was concentrated to dryness, pulpifying for 1 hour after adding 8 ml saturated sodium bicarbonate solution, and filtered to obtain 2.29 g yellow solid. Yield: 87.5%. Purity: 95.3% (HPLC). EI-MS (m/z): 355.2. HNMR (400 MHz, DMSO, ppm) |?7.32 (d, J=8.8 Hz, 2H), 7.26 (d, J=8.8 Hz, 2H), 5.71 (t, J=4.8 Hz, 1H), 3.72-3.69 (m, 2H), 3.65-3.63 (m, 4H), 3.60-3.57 (m, 2H), 2.79-2.77 (m, 4H), 2.44-2.41 (m, 2H), 2.40-2.39 (m, 2H), 1.88-1.82 (m, 4H).

3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one Suppliers

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View Lastest Price from 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one manufacturers

Wuhan Biocar Pharmacy CO.,Ltd.
Product
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one 545445-44-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
800kg
Release date
2025-03-12
Speranza Chemical Co., Ltd.
Product
3-morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one 545445-44-1
Price
US $20.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20 tons
Release date
2019-12-24
Jinan Million Pharmaceutical Co., Ltd
Product
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one 545445-44-1
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1200KG/M
Release date
2023-08-15

545445-44-1, 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-oneRelated Search:

1-(4-(2-methyl-6-oxopiperidin-1-yl)phenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one (4,4'‐didodecyl‐2,2'‐ bithiophene‐5,5'‐ diyl)bis(triMethylstann ane) Apixaban-13C-D3 Apixaban IMpurity(BMS-778960-01) 1,3-bis(4-bromophenyl)propan-2-one Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 1-(4-Nitrophenyl)-2-piperidinone 4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-6-[4-(5-methyl-2-oxo-1-piperidinyl)phenyl]-7-oxo-1H-pyrazolo[3,4-c]pyridine-3-carboxamide 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid Apixaban Apixaban IMpurity 6 5-chloro-N-(4-(5-morpholino-6-oxo-3,6-dihydropyridin-1(2H)-yl)phenyl)pentanamide 1-(4-Methoxyphenyl)-6-(4-iodophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester ethyl 1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate 1-(4-Hydroxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide Apixaban IMpurity 5 (BMS-591329-01)

  • 5-morpholin-4-yl-1-[4-(2-oxopiperidin-1-yl)phenyl]-2,3-dihydropyridin-6-one
  • 3-Morpholino-1-[4-(2-oxo-1-piperidyl)phenyl]-5,6-dihydropyridin-2(1H)-one
  • 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)
  • HSK00001094
  • Apixaban Impurity H
  • Apixaban Intermediates
  • Apixaban Impurity P
  • 3-Morpholin-4-yl-1-[4-(2-oxopiperidin-1-yl)phenyl]-5,6-dihydro-1H-pyridin-2-one
  • 5,6-Dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-1-piperidinyl)phenyl]-2(1H)-pyridinone
  • 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
  • Apixaba inretMediate B
  • Apixaban Intermediate B
  • Apixaban Intermediate 2
  • 3-Morpholin-4-yl-1-[4-(2-oxopiperidin-1-yl)phenyl]-5,6-dihydro-1H-pyridin-2-one (Apixaban)
  • 5,6-Dihydro-3-(morpholinyl)-1[4-(2-oxo-1- piperidinyl)phenyl]-2(1H)-pyridinone
  • Apixaban-1
  • 5,6-dihydro-3-(4-morpholine)-1-[4-(2-oxy-1-piperidyl) phenyl ]-2(1 H)-pyridone
  • -1-[4-(2-oxopiperidin-1-yL
  • in-4-yL
  • 2(1H)-Pyridinone, 5,6-dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-1-piperidinyl)phenyl]-
  • ]-5,6-dihydro-1H-pyridin-2-one
  • 5, 6-dihydro-3 -(4-morpholine)-1-[4-(2-oxo-1-piperidyl) phenyl]-2(1H) -pyridinone
  • ApixabanGF Impurity 1 ABCDEFGHJKL
  • APIXABAN CAS 503612-47-3 INTERMEDIATES
  • ，3-Morpholino-1-(4-(2-oxopiperidin-1- yl)phenyl)-5,6-dihydropyridin-2(1H)- oneethyl 7-chloro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate
  • Apixaban intermediates，5,6-Dihydro-3-(4-morpholinyl)-1-[4-(2- oxo-1-piperidinyl)phenyl]-2(1H)- pyridinone
  • Apixaban Dihydro pyridenone
  • 5,6-Dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-1-piperidinyl)phen...
  • Impurity of apixaban383
  • 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)
  • 3-(4-Morpholinyl)-1-[4-(2-oxo-1-piperidinyl)phenyl]-5,6-dihydro-2(1H)-pyridinone
  • 2(1H)-Quinolinone,3,4-dihydro-13-hydroxy-
  • RSYY(Apremilast)-36
  • 5,6-Dihydro-3-morpholino-1-(4-(2-oxopiperidin-1-phenyl)pyridin-2(1H)-one
  • 5,6-Dihydro-3-Morpholino-1-(4-(2-oxo Piperidin-1-yl) Ph)Py)2(1H) one
  • 3-Morpholino-1-[4-(2-oxo-1-piperidyl)phenyl]-5,6-dhydropyridin-2(1H)-one
  • 3-(morpholin-4-yl)-1-[4-(2-oxopiperidin-1-yl)phenyl]-1,2,5,6-tetrahydropyridin-2-one
  • Anticancer agent 209
  • 3-(4-Morpholinyl)-1-[4-(2-Oxo-1-Piperidinyl)Phenyl]-5,6-Dih
  • Apixaban morpholine lactum impurity 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6- dihydropyridin-2(1H)-one
  • 3-Morpholino-1-[4-(2-oxopiperidin-1-yl)phenyl]-5,6-dihvdropvridin-2(1H)-one
  • ethyl 1-(3-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate
  • 3-morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one (Intermediate of Apixaban)
  • Apixaban Inter.
  • 5,6-Dihydro-3-morpholin-4-yl-1-[4-(2-oxo-piperidin-1-yl)phenyl]-2(1H)-pyridinone
  • 545445-44-1