FH 535
- Product Name
- FH 535
- CAS No.
- 108409-83-2
- Chemical Name
- FH 535
- Synonyms
- FH 535;CS-1433;FH 535(FH-535);FH 535 USP/EP/BP;FH535;FH 535;FH-535;β-Catenin/Tcf Inhibitor, FH535;2,5-Dichloro-N-(2-Methyl-4-nitrophenyl)benzenesulfonaMide;N-(2-Methyl-4-nitrophenyl)-2,5-dichlorobenzenesulfonaMide;Benzenesulfonamide, 2,5-dichloro-N-(2-methyl-4-nitrophenyl)-;β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem
- CBNumber
- CB62552602
- Molecular Formula
- C13H10Cl2N2O4S
- Formula Weight
- 361.2
- MOL File
- 108409-83-2.mol
FH 535 Property
- Melting point:
- 141-142℃
- Boiling point:
- 526.3±60.0 °C(Predicted)
- Density
- 1.566±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble20mg/mL
- form
- Yellow solid
- pka
- 5.83±0.10(Predicted)
- color
- Tan
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
- InChIKey
- AXNUEXXEQGQWPA-UHFFFAOYSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F5682
- Product name
- FH535
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 219330
- Product name
- β-Catenin/Tcf Inhibitor, FH535
- Packaging
- 10mg
- Price
- $144
- Updated
- 2024/03/01
- Product number
- 18001
- Product name
- FH535
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 18001
- Product name
- FH535
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $84
- Updated
- 2024/03/01
- Product number
- F5682
- Product name
- FH535
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $419
- Updated
- 2024/03/01
FH 535 Chemical Properties,Usage,Production
Description
FH-535 (108409-83-2) suppresses Wnt/β-catenin signaling. It antagonizes PPARγ and PPARδ ligand-dependent activation which is mediated by inhibition of recruitment of the coactivators β-catenin and GRIP1 but not the corepressors NCoR and SMRT.1?Inhibits the migration and growth of breast cancer cell lines2 as well as colon, lung and liver cell lines1. FH-535 is a useful tool for probing the involvement of Wnt signaling pathway.3,4
Chemical Properties
Dark Yellow Solid
Uses
A cell-permeable compound that inhibits Wnt/β-catenin and PPAR
Uses
Antagonizes Wnt/β-catenin/Tcf-mediated transcription as well as PPARγ and δ activity. Able to inhibit the recruitment of the co-activators β-catenin and GRIP1, both of which are activators for both pathways.
Definition
ChEBI: 2,5-dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide is a sulfonamide.
Biochem/physiol Actions
FH535 has the ability to block the development of colon cancer cells. It can change several cancer-associated biological processes. FH535 can also prevent PARylation of Axin2 in osteosarcoma cells.
storage
+4°C
References
1) Handeli et al. (2008), A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities; Mol. Cancer Ther., 7 521 2) Iida et al. (2012), FH535 inhibited migration and growth of breast cancer cells; PLoS One, 7 e44418 3) Frewer et al. (2013), A role for WISP2 in colorectal cancer cell invasion and motility; Cancer Genomics Proteomics, 10 187 4) Polk et al. (2012), FH535 potentiation of cigarette smoke condensate cytotoxicity is associated with changes in β-catenin and EGR-1 signaling; Int. J. Toxicol., 31 380 5) Morita and Hayashi (2018), Tumor Progression is Mediated by Thymosin-β4 through a TGFβ/MRTF Signaling Axis; Mol. Cancer Res. 16(5) 880
FH 535 Preparation Products And Raw materials
Raw materials
Preparation Products
FH 535 Suppliers
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2923
- Advantage
- 55
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6011
- Advantage
- 61
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32344
- Advantage
- 50
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
- Country
- China
- ProdList
- 4647
- Advantage
- 58
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7553
- Advantage
- 61
- Tel
- 021-58958002 18930822973
- Fax
- +86 (21) 5895-8628
- SALES@UHNSHANGHAI.COM
- Country
- China
- ProdList
- 977
- Advantage
- 58
- Tel
- 18521735133 18521732826;
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25015
- Advantage
- 65
- Tel
- +1 (866) 930-6790
- Fax
- +1 (866) 333-9607
- info@adooq.com
- Country
- United States
- ProdList
- 2784
- Advantage
- 58
- Tel
- Mobile:13665161512
- Fax
- +86-510-68873513
- Country
- China
- ProdList
- 1785
- Advantage
- 58
View Lastest Price from FH 535 manufacturers
- Product
- FH 535 108409-83-2
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-08