FH 535

Product Name: FH 535
CAS No.: 108409-83-2
Chemical Name: FH 535
Synonyms: FH 535;CS-1433;FH 535(FH-535);FH 535 USP/EP/BP;FH535;FH 535;FH-535;β-Catenin/Tcf Inhibitor, FH535;β-Catenin/Tcf Inhibitor, FH535;FH-535, Wnt/beta-cantenin inhibitor;2,5-Dichloro-N-(2-Methyl-4-nitrophenyl)benzenesulfonaMide;N-(2-Methyl-4-nitrophenyl)-2,5-dichlorobenzenesulfonaMide
CBNumber: CB62552602
Molecular Formula: C13H10Cl2N2O4S
Formula Weight: 361.2
MOL File: 108409-83-2.mol

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FH 535 Property

Melting point:: 141-142℃
Boiling point:: 526.3±60.0 °C(Predicted)
Density: 1.566±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble20mg/mL
form: Yellow solid
pka: 5.83±0.10(Predicted)
color: Tan
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChIKey: AXNUEXXEQGQWPA-UHFFFAOYSA-N

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Safety

Hazard Codes: Xi
Risk Statements: 41
Safety Statements: 36
WGK Germany: 3
HS Code: 29350090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: F5682
Product name: FH535
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Sigma-Aldrich

Product number: 219330
Product name: β-Catenin/Tcf Inhibitor, FH535
Packaging: 10mg
Price: $144
Updated: 2024/03/01

Cayman Chemical

Product number: 18001
Product name: FH535
Purity: ≥95%
Packaging: 5mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18001
Product name: FH535
Purity: ≥95%
Packaging: 10mg
Price: $84
Updated: 2024/03/01

Sigma-Aldrich

Product number: F5682
Product name: FH535
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $419
Updated: 2024/03/01

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FH 535 Chemical Properties,Usage,Production

Description

FH-535 (108409-83-2) suppresses Wnt/β-catenin signaling. It antagonizes PPARγ and PPARδ ligand-dependent activation which is mediated by inhibition of recruitment of the coactivators β-catenin and GRIP1 but not the corepressors NCoR and SMRT.1?Inhibits the migration and growth of breast cancer cell lines2 as well as colon, lung and liver cell lines1. FH-535 is a useful tool for probing the involvement of Wnt signaling pathway.3,4

Chemical Properties

Dark Yellow Solid

Uses

A cell-permeable compound that inhibits Wnt/β-catenin and PPAR

Uses

Antagonizes Wnt/β-catenin/Tcf-mediated transcription as well as PPARγ and δ activity. Able to inhibit the recruitment of the co-activators β-catenin and GRIP1, both of which are activators for both pathways.

Definition

ChEBI: 2,5-dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide is a sulfonamide.

Biochem/physiol Actions

FH535 has the ability to block the development of colon cancer cells. It can change several cancer-associated biological processes. FH535 can also prevent PARylation of Axin2 in osteosarcoma cells.

storage

+4°C

References

1) Handeli et al. (2008), A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities; Mol. Cancer Ther., 7 521 2) Iida et al. (2012), FH535 inhibited migration and growth of breast cancer cells; PLoS One, 7 e44418 3) Frewer et al. (2013), A role for WISP2 in colorectal cancer cell invasion and motility; Cancer Genomics Proteomics, 10 187 4) Polk et al. (2012), FH535 potentiation of cigarette smoke condensate cytotoxicity is associated with changes in β-catenin and EGR-1 signaling; Int. J. Toxicol., 31 380 5) Morita and Hayashi (2018), Tumor Progression is Mediated by Thymosin-β4 through a TGFβ/MRTF Signaling Axis; Mol. Cancer Res. 16(5) 880

FH 535 Preparation Products And Raw materials

Raw materials

Preparation Products

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FH 535 Suppliers

Canada 1 China 97 India 2 United Kingdom 2 United States 18 Global 120

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
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Target molecule Corp.

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TargetMol Chemicals Inc.

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InvivoChem

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Cckinase, Inc.

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Aladdin Scientific

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Santa Cruz Biotechnology, Inc.

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View Lastest Price from FH 535 manufacturers

Career Henan Chemical Co

Product: FH 535 108409-83-2
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-08

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β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem

CS-1433

FH 535

N-(2-Methyl-4-nitrophenyl)-2,5-dichlorobenzenesulfonaMide

2,5-Dichloro-N-(2-Methyl-4-nitrophenyl)benzenesulfonaMide

2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide FH535

β-Catenin/Tcf Inhibitor, FH535

FH 535(FH-535)

FH535;FH 535;FH-535

FH535, 98%, a cell-permeable compound that inhibits Wnt/β-catenin and PPAR

Benzenesulfonamide, 2,5-dichloro-N-(2-methyl-4-nitrophenyl)-

FH 535 USP/EP/BP

FH 535,Beta catenin,β-catenin,FH535,inhibit,FH-535,PPAR,Wnt,Inhibitor,Peroxisome proliferator-activated receptors

β-Catenin/Tcf Inhibitor, FH535

FH-535, Wnt/beta-cantenin inhibitor

108409-83-2

API

Aromatics

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals